Prehospital Transdermal Glyceryl Trinitrate for Ultra-Acute Intracerebral Hemorrhage

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[1]  J. Broderick,et al.  Early hemorrhage growth in patients with intracerebral hemorrhage. , 1997, Stroke.

[2]  A. Kanner To Treat or Not to Treat…Is it Still the Question? , 2007, Epilepsy currents.

[3]  P. Bath,et al.  Blood Pressure–Lowering Treatment With Candesartan in Patients With Acute Hemorrhagic Stroke , 2014, Stroke.

[4]  D. Hanley,et al.  Spontaneous Intracerebral Hemorrhage , 2012, Neuromethods.

[5]  M. Woodward,et al.  Rapid blood-pressure lowering in patients with acute intracerebral hemorrhage. , 2013, The New England journal of medicine.

[6]  Askiel Bruno,et al.  Improving Modified Rankin Scale Assessment With a Simplified Questionnaire , 2010, Stroke.

[7]  Peter J. Godolphin,et al.  Prehospital transdermal glyceryl trinitrate in patients with ultra-acute presumed stroke ( RIGHT-2 ) : an ambulance-based , randomised , sham-controlled , blinded , phase 3 trial , 2019 .

[8]  S. Gosselin,et al.  Intensive blood-pressure lowering in patients with acute cerebral hemorrhage. , 2018, CJEM.

[9]  C. Anderson,et al.  Effect of Treatment Delay, Stroke Type, and Thrombolysis on the Effect of Glyceryl Trinitrate, a Nitric Oxide Donor, on Outcome after Acute Stroke: A Systematic Review and Meta-Analysis of Individual Patient from Randomised Trials , 2016, Stroke research and treatment.

[10]  S. Avikainen,et al.  Prognostic value and determinants of first-day mean arterial pressure in spontaneous supratentorial intracerebral hemorrhage. , 1997, Stroke.

[11]  Michael D Hill,et al.  Determinants of Intracerebral Hemorrhage Growth: An Exploratory Analysis , 2007, Stroke.

[12]  Jackson T. Wright,et al.  2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. , 2018, Journal of the American College of Cardiology.

[13]  S. Pocock,et al.  Glyceryl Trinitrate for Acute Intracerebral Hemorrhage: Results From the Efficacy of Nitric Oxide in Stroke (ENOS) Trial, a Subgroup Analysis , 2016, Stroke.

[14]  P. Bath,et al.  Blood Pressure in Acute Stroke: To Treat or Not to Treat: That Is Still the Question. , 2018, Stroke.

[15]  Joanna M. Wardlaw,et al.  Association between brain imaging signs, early and late outcomes, and response to intravenous alteplase after acute ischaemic stroke in the third International Stroke Trial (IST-3): secondary analysis of a randomised controlled trial , 2015, The Lancet Neurology.

[16]  R. Brook,et al.  2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults. A report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. , 2018, Journal of the American Society of Hypertension : JASH.

[17]  D. Krieger,et al.  European Stroke Organisation (ESO) Guidelines for the Management of Spontaneous Intracerebral Hemorrhage , 2014, International journal of stroke : official journal of the International Stroke Society.

[18]  John M. Lachin,et al.  Applications of the Wei-Lachin Multivariate One-Sided Test for Multiple Outcomes on Possibly Different Scales , 2014, PloS one.

[19]  Lawrence A Leiter,et al.  Hypertension Canada's 2017 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults. , 2017, The Canadian journal of cardiology.

[20]  C. Anderson,et al.  Intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT): a randomised pilot trial , 2008, The Lancet Neurology.

[21]  A. Divani,et al.  Prevalence of elevated blood pressure in 563,704 adult patients with stroke presenting to the ED in the United States. , 2007, The American journal of emergency medicine.

[22]  J. Wardlaw,et al.  Effect of Hyperacute Administration (Within 6 Hours) of Transdermal Glyceryl Trinitrate, a Nitric Oxide Donor, on Outcome After Stroke: Subgroup Analysis of the Efficacy of Nitric Oxide in Stroke (ENOS) Trial , 2015, Stroke.

[23]  S. Pocock,et al.  Ambulance-delivered transdermal glyceryl trinitrate versus sham for ultra-acute stroke: Rationale, design and protocol for the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2) trial (ISRCTN26986053) , 2019, International journal of stroke : official journal of the International Stroke Society.

[24]  S. Pocock,et al.  Statistical analysis plan for the ‘Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2)’ , 2018, European stroke journal.

[25]  D. Hanley,et al.  Intensive Blood-Pressure Lowering in Patients with Acute Cerebral Hemorrhage. , 2016, The New England journal of medicine.

[26]  E. T. Investigators,et al.  Efficacy of nitric oxide, with or without continuing antihypertensive treatment, for management of high blood pressure in acute stroke (ENOS): a partial-factorial randomised controlled trial , 2015, The Lancet.