A Hybrid Microfluidic/CMOS Capacitive Sensor Dedicated to Lab-on-Chip Applications

A hybrid microfluidic/IC capacitive sensor is presented in this paper for highly integrated lab-on-chips (LoCs). We put forward the design and implementation of a charge based capacitive sensor array in 0.18-mum CMOS process. This sensor chip is incorporated with a microfluidic channel using direct-write microfluidic fabrication process (DWFP). The design, construction and experimental results as well are demonstrated using four different chemical solutions with known dielectric constants. The proposed highly sensitive CMOS capacitive sensor (ap530 mV/fF) along with low complexity DWFP emerges as clear favorite for LoC applications.

[1]  N. Yazdi,et al.  Noise analysis and characterization of a sigma-delta capacitive microaccelerometer , 2006, IEEE Journal of Solid-State Circuits.

[2]  A. Hierlemann Integrated chemical microsensor systems in CMOS-technology , 2005, The 13th International Conference on Solid-State Sensors, Actuators and Microsystems, 2005. Digest of Technical Papers. TRANSDUCERS '05..

[3]  C Guiducci,et al.  DNA detection by integrable electronics. , 2004, Biosensors & bioelectronics.

[4]  C. Hu,et al.  Investigation of interconnect capacitance characterization using charge-based capacitance measurement (CBCM) technique and three-dimensional simulation , 1998 .

[5]  R. Puers,et al.  Ultra-Low-Power Interface Chip for Autonomous Capacitive Sensor Systems , 2007, IEEE Transactions on Circuits and Systems I: Regular Papers.

[6]  P. Abshire,et al.  On-Chip Capacitance Sensing for Cell Monitoring Applications , 2007, IEEE Sensors Journal.

[7]  L. Benini,et al.  CMOS DNA Sensor Array With Integrated A/D Conversion Based on Label-Free Capacitance Measurement , 2006, IEEE Journal of Solid-State Circuits.

[8]  Bharat L. Bhuva,et al.  Si-based sensor for virus detection , 2005 .

[9]  F. O. Eynde,et al.  A high-speed CMOS comparator with 8-b resolution , 1992 .

[10]  M. Sawan,et al.  High accuracy differential capacitive circuit for bioparticles sensing applications , 2005, 48th Midwest Symposium on Circuits and Systems, 2005..

[11]  R. Thewes,et al.  A Fully Electronic Label-Free DNA Sensor Chip , 2007, IEEE Sensors Journal.

[12]  Ebrahim Ghafar-Zadeh,et al.  A CMOS-Based Capacitive Sensor for Laboratory-On-Chips: Design and Experimental Results , 2007, 2007 IEEE International Symposium on Circuits and Systems.

[13]  I. Miller Probability, Random Variables, and Stochastic Processes , 1966 .

[14]  Mohamad Sawan,et al.  Novel direct-write CMOS-based laboratory-on-chip: Design, assembly and experimental results , 2007 .

[15]  R. Guerrieri,et al.  Capacitive sensor array for localization of bioparticles in CMOS lab-on-a-chip , 2004, 2004 IEEE International Solid-State Circuits Conference (IEEE Cat. No.04CH37519).