The biologic effects of implant materials

The interaction between implant materials and the surrounding biological environment continues to be an area of intense research and clinical interest. This article presents the information presented in a symposium, held during the 36th Annual Meeting of the Orthopaedic Research Society, in which several important issues concerning the biologic effects of implant materials were discussed. These issues included the mechanisms by which implant materials are released to the surrounding tissues and the ways in which these tissues respond to implant materials. The problem of bone loss around cementless implants was discussed as a specific example of a biologic effect resulting in both bone remodelling and endosteal erosion.

[1]  G. Daculsi,et al.  Macroporous calcium phosphate ceramic for long bone surgery in humans and dogs. Clinical and histological study. , 1990, Journal of biomedical materials research.

[2]  J. Lamovec,et al.  Synovial sarcoma associated with total hip replacement. A case report. , 1988, The Journal of bone and joint surgery. American volume.

[3]  C. Adler,et al.  Malignant fibrous histiocytoma in association with hip replacement. , 1989, The Journal of bone and joint surgery. British volume.

[4]  J. Nerup,et al.  Endotoxin‐Stimulated Human Monocyte Secretion of Interleukin 1, Tumour Necrosis Factor Alpha, and Prostaglandin E2 Shows Stable Interindividual Differences , 1988, Scandinavian journal of immunology.

[5]  J E Lemons,et al.  Properties of biomaterials. , 1986, The Journal of arthroplasty.

[6]  H. Hansson,et al.  Electron microscopic analysis of the bone-titanium interface. , 1983, Acta orthopaedica Scandinavica.

[7]  C. Frampton,et al.  The incidence of cancer following total hip replacement. , 1988, The Journal of bone and joint surgery. British volume.

[8]  J. Szivek,et al.  The effect of proximally and fully porous‐coated canine hip stem design on bone modeling , 1987, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[9]  P. Weber.  Epithelioid sarcoma in association with total knee replacement. A case report. , 1986, The Journal of bone and joint surgery. British volume.

[10]  J. Galante,et al.  Malignant neoplasms associated with orthopedic implant materials in rats , 1986, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[11]  J. Lemons.  Dental implant retrieval analyses. , 1988, Journal of dental education.

[12]  J. Galante,et al.  A comparative study of porous coatings in a weight-bearing total hip-arthroplasty model. , 1986, The Journal of bone and joint surgery. American volume.

[13]  C. Evans,et al.  The synovial production of collagenase and chondrocyte activating factors in response to cobalt , 1988, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[14]  T. Albrektsson,et al.  The Branemark Osseointegrated Implant , 1989 .

[15]  C. Engh,et al.  Porous-coated hip replacement. The factors governing bone ingrowth, stress shielding, and clinical results. , 1987, The Journal of bone and joint surgery. British volume.

[16]  Engh Ca,et al.  The influence of stem size and extent of porous coating on femoral bone resorption after primary cementless hip arthroplasty. , 1988 .

[17]  R. L. Carter,et al.  Sarcoma and joint replacement. , 1984, The Journal of bone and joint surgery. British volume.

[18]  T Albrektsson,et al.  Osseointegration of bone implants. A review of an alternative mode of fixation. , 1987, Acta orthopaedica Scandinavica.

[19]  D. Murray,et al.  The influence of the surface energy and roughness of implants on bone resorption. , 1989, The Journal of bone and joint surgery. British volume.

[20]  S. Robbins,et al.  Pathologic basis of disease , 1974 .

[21]  D. Howie,et al.  A rat model of resorption of bone at the cement-bone interface in the presence of polyethylene wear particles. , 1988, The Journal of bone and joint surgery. American volume.

[22]  L. Lucas,et al.  Ultrastructural Examination of In Vitro and In Vivo Cells Exposed to Elements from Type 316L Stainless Steel , 1985 .

[23]  T. Bauer,et al.  Osteosarcoma at the site of total hip replacement. A case report. , 1988, The Journal of bone and joint surgery. American volume.

[24]  P. Ring,et al.  Osteosarcoma in association with total hip replacement , 1984, The Journal of bone and joint surgery. British volume.

[25]  G. Rodan,et al.  Cyclic AMP and cyclic GMP: mediators of the mechanical effects on bone remodeling. , 1975, Science.

[26]  P. Ring,et al.  Osteolytic changes in the upper femoral shaft following porous-coated hip replacement. , 1985, The Journal of bone and joint surgery. British volume.

[27]  W H Harris,et al.  Extensive localized bone resorption in the femur following total hip replacement. , 1976, The Journal of bone and joint surgery. American volume.

[28]  T. Yamamuro,et al.  Bonding behavior between two bioactive ceramics in vivo. , 1987, Journal of biomedical materials research.

[29]  J. Galante,et al.  Symmetry of the canine femur: Implications for experimental sample size requirements , 1988, Journal of Orthopaedic Research.

[30]  A. Malcolm,et al.  Malignant fibrous histiocytoma occurring at the site of a previous total hip replacement. , 1988, The British journal of radiology.

[31]  T Albrektsson,et al.  An ultrastructural characterization of the interface between bone and sputtered titanium or stainless steel surfaces. , 1986, Biomaterials.

[32]  M. Swann.  Malignant soft-tissue tumour at the site of a total hip replacement. , 1984, The Journal of bone and joint surgery. British volume.

[33]  H. Möller,et al.  Trends and forecasts for standard allergens in a 12‐year patch test material , 1982, Contact dermatitis.

[34]  D. A. Willoughby,et al.  The formation of a structure with the features of synovial lining by subcutaneous injection of air: An in vivo tissue culture system , 1981, The Journal of pathology.

[35]  W H Harris,et al.  Localized osteolysis in stable, non-septic total hip replacement. , 1986, The Journal of bone and joint surgery. American volume.

[36]  J. Black,et al.  Release of corrosion products by F-75 cobalt base alloy in the rat. III: Effects of a carbon surface coating. , 1987, Journal of biomedical materials research.

[37]  J. V. van Horn,et al.  Malignant epithelioid hemangioendothelioma at the site of a hip prosthesis. , 1988, Acta orthopaedica Scandinavica.

[38]  H R Schumacher,et al.  Prolonged inflammatory reactions induced by artificial ceramics in the rat air pouch model. , 1988, The Journal of rheumatology.

[39]  T Kitsugi,et al.  Ca,P-rich layer formed on high-strength bioactive glass-ceramic A-W. , 1990, Journal of biomedical materials research.

[40]  C. Sledge,et al.  Biochemical and histological evaluation of the synovial-like tissue around failed (loose) total joint replacement prostheses in human subjects and a canine model. , 1990, Biomaterials.

[41]  J. Lemons,et al.  In Vitro Corrosion of Porous Alloys , 1987 .

[42]  H. D. Huddleston.  Femoral lysis after cemented hip arthroplasty. , 1988, The Journal of arthroplasty.

[43]  E. Salvati,et al.  Osteogenic sarcoma arising in the area of a total hip replacement. A case report. , 1990, The Journal of bone and joint surgery. American volume.

[44]  S D Cook,et al.  Interface mechanics and histology of titanium and hydroxylapatite-coated titanium for dental implant applications. , 1987, The International journal of oral & maxillofacial implants.

[45]  G Boivin,et al.  Osseointegration of metallic implants. II. Transmission electron microscopy in the rabbit. , 1989, Acta orthopaedica Scandinavica.

[46]  W H Harris,et al.  Formation of a synovial-like membrane at the bone-cement interface. Its role in bone resorption and implant loosening after total hip replacement. , 1986, Arthritis and rheumatism.

[47]  M. Ritter,et al.  Distal cortical hypertrophy following total hip arthroplasty. , 1988, The Journal of arthroplasty.

[48]  K. Markolf,et al.  Friction and wear properties of polymer, metal, and ceramic prosthetic joint materials evaluated on a multichannel screening device. , 1981, Journal of biomedical materials research.

[49]  Jack E. Lemons,et al.  Quantitative characterization and performance of porous implants for hard tissue applications : a symposium sponsored by ASTM Committee F-4 on Medical and Surgical Materials and Devices, Nashville, TN, 18-19 Nov. 1985 , 1987 .

[50]  N. Tallada,et al.  Malignant fibrous histiocytoma of bone at the site of a total hip arthroplasty. A case report. , 1984, The Journal of bone and joint surgery. British volume.

[51]  H. Selye,et al.  Use of “Granuloma Pouch” Technic in the Study of Antiphlogistic Corticoids∗ , 1953, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[52]  W H Harris,et al.  The synovial-like membrane at the bone-cement interface in loose total hip replacements and its proposed role in bone lysis. , 1983, The Journal of bone and joint surgery. American volume.

[53]  C. Klein,et al.  Bonding of bone to apatite-coated implants. , 1988, The Journal of bone and joint surgery. British volume.

[54]  Surgical Materials,et al.  Corrosion and degradation of implant materials : second symposium , 1985 .

[55]  M Gineste,et al.  Physicochemical characterization of deposits associated with HA ceramics implanted in nonosseous sites. , 1988, Journal of biomedical materials research.

[56]  H. Selye.  On the mechanism through which hydrocortisone affects the resistance of tissues to injury; an experimental study with the granuloma pouch technique. , 1953, Journal of the American Medical Association.