Impaired dopamine metabolism in Parkinson’s disease pathogenesis
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[1] W. Burke,et al. Aldehyde adducts inhibit 3,4‐dihydroxyphenylacetaldehyde‐induced &agr;‐synuclein aggregation and toxicity: Implication for Parkinson neuroprotective therapy , 2019, European journal of pharmacology.
[2] D. Eliezer,et al. Role of Parkinson's Disease-Linked Mutations and N-Terminal Acetylation on the Oligomerization of α-Synuclein Induced by 3,4-Dihydroxyphenylacetaldehyde. , 2018, ACS chemical neuroscience.
[3] A. Whitworth,et al. Superoxide Radical Dismutation as New Therapeutic Strategy in Parkinson’s Disease , 2018, Aging and disease.
[4] J. Fitzgerald,et al. The Therapeutic Potential of Metformin in Neurodegenerative Diseases , 2018, Front. Endocrinol..
[5] D. Goldstein,et al. 3,4-Dihydroxyphenylacetaldehyde-Induced Protein Modifications and Their Mitigation by N-Acetylcysteine , 2018, The Journal of Pharmacology and Experimental Therapeutics.
[6] S. Crovella,et al. MAO‐B and COMT Genetic Variations Associated With Levodopa Treatment Response in Patients With Parkinson's Disease , 2018, Journal of clinical pharmacology.
[7] K. Ye,et al. α‐Synuclein stimulation of monoamine oxidase‐B and legumain protease mediates the pathology of Parkinson's disease , 2018, The EMBO journal.
[8] V. Giorgio,et al. Dopamine Oxidation Products as Mitochondrial Endotoxins, a Potential Molecular Mechanism for Preferential Neurodegeneration in Parkinson's Disease. , 2018, ACS chemical neuroscience.
[9] D. Krainc,et al. LRRK2 phosphorylation of auxilin mediates synaptic defects in dopaminergic neurons from patients with Parkinson’s disease , 2018, Proceedings of the National Academy of Sciences.
[10] J. Andersen,et al. An inducible MAO-B mouse model of Parkinson’s disease: a tool towards better understanding basic disease mechanisms and developing novel therapeutics , 2018, Journal of Neural Transmission.
[11] L. Bubacco,et al. Diabetes Mellitus as a Risk Factor for Parkinson’s Disease: a Molecular Point of View , 2018, Molecular Neurobiology.
[12] A. De Simone,et al. Order and disorder in the physiological membrane binding of α-synuclein. , 2018, Current opinion in structural biology.
[13] Christopher V. Rao,et al. Ancient Regulatory Role of Lysine Acetylation in Central Metabolism , 2017, mBio.
[14] S. Schneider,et al. Neuropathology of genetic synucleinopathies with parkinsonism: Review of the literature , 2017, Movement disorders : official journal of the Movement Disorder Society.
[15] Subhojit Roy. Synuclein and dopamine: the Bonnie and Clyde of Parkinson's disease , 2017, Nature Neuroscience.
[16] D. Murry,et al. Inactivation of glyceraldehyde-3-phosphate dehydrogenase by the dopamine metabolite, 3,4-dihydroxyphenylacetaldehyde. , 2017, Biochemical and biophysical research communications.
[17] D. Surmeier,et al. Parkinson's Disease Is Not Simply a Prion Disorder , 2017, The Journal of Neuroscience.
[18] G. Jeong,et al. Metformin lowers α-synuclein phosphorylation and upregulates neurotrophic factor in the MPTP mouse model of Parkinson's disease , 2017, Neuropharmacology.
[19] J. Schultze,et al. Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis in the aged , 2017, Nature.
[20] Sohee Jeon,et al. Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease , 2017, Science.
[21] R. Kalb,et al. Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration , 2017, Nature Neuroscience.
[22] Michael L. Wallace,et al. Multi-transmitter neurons in the mammalian central nervous system , 2017, Current Opinion in Neurobiology.
[23] D. Lovinger,et al. Aldehyde dehydrogenase 1–positive nigrostriatal dopaminergic fibers exhibit distinct projection pattern and dopamine release dynamics at mouse dorsal striatum , 2017, Scientific Reports.
[24] N. Seyfried,et al. Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease , 2017, Nature Structural &Molecular Biology.
[25] A. Bax,et al. Superoxide is the critical driver of DOPAL autoxidation, lysyl adduct formation, and crosslinking of α-synuclein. , 2017, Biochemical and biophysical research communications.
[26] O. Mabrouk,et al. Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice , 2017, Acta neuropathologica communications.
[27] K. Thorn,et al. α-Synuclein Promotes Dilation of the Exocytotic Fusion Pore , 2017, Nature Neuroscience.
[28] D. Krainc,et al. α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies , 2017, Nature Medicine.
[29] O. Tysnes,et al. Epidemiology of Parkinson’s disease , 2017, Journal of Neural Transmission.
[30] Ole Isacson,et al. The Threshold Theory for Parkinson's Disease , 2017, Trends in Neurosciences.
[31] D. James Surmeier,et al. Selective neuronal vulnerability in Parkinson disease , 2017, Nature Reviews Neuroscience.
[32] L. Bubacco,et al. DOPAL derived alpha-synuclein oligomers impair synaptic vesicles physiological function , 2017, Scientific Reports.
[33] R. Strong,et al. Neurochemical and motor changes in mice with combined mutations linked to Parkinson’s disease , 2017, Pathobiology of aging & age related diseases.
[34] D. Goldstein,et al. Elevated cerebrospinal fluid ratios of cysteinyl-dopamine/3,4-dihydroxyphenylacetic acid in parkinsonian synucleinopathies. , 2016, Parkinsonism & related disorders.
[35] M. Khaniani,et al. Genetic Analysis of the ZNF512B, SLC41A1, and ALDH2 Polymorphisms in Parkinson's Disease in the Iranian Population. , 2016 .
[36] H. Cai,et al. Role of ADH2 and ALDH2 gene polymorphisms in the development of Parkinson's disease in a Chinese population. , 2016, Genetics and molecular research : GMR.
[37] S. Valentine,et al. Acetylation within the First 17 Residues of Huntingtin Exon 1 Alters Aggregation and Lipid Binding. , 2016, Biophysical journal.
[38] R. Wu,et al. Aldehyde dehydrogenase 2 is associated with cognitive functions in patients with Parkinson’s disease , 2016, Scientific Reports.
[39] A. Bax,et al. Nuclear Magnetic Resonance Observation of α-Synuclein Membrane Interaction by Monitoring the Acetylation Reactivity of Its Lysine Side Chains , 2016, Biochemistry.
[40] M. Ivanova,et al. Neurotoxicity of the Parkinson Disease-Associated Pesticide Ziram Is Synuclein-Dependent in Zebrafish Embryos , 2016, Environmental health perspectives.
[41] J. Doorn,et al. Antioxidant-Mediated Modulation of Protein Reactivity for 3,4-Dihydroxyphenylacetaldehyde, a Toxic Dopamine Metabolite. , 2016, Chemical research in toxicology.
[42] Abid Oueslati. Implication of Alpha-Synuclein Phosphorylation at S129 in Synucleinopathies: What Have We Learned in the Last Decade? , 2016, Journal of Parkinson's disease.
[43] L. Bubacco,et al. Lysines, Achilles’ heel in alpha-synuclein conversion to a deadly neuronal endotoxin , 2016, Ageing Research Reviews.
[44] D. Krainc,et al. Detection of Free and Protein-Bound ortho-Quinones by Near-Infrared Fluorescence. , 2016, Analytical chemistry.
[45] D. Goldstein,et al. Comparison of Monoamine Oxidase Inhibitors in Decreasing Production of the Autotoxic Dopamine Metabolite 3,4-Dihydroxyphenylacetaldehyde in PC12 Cells , 2016, The Journal of Pharmacology and Experimental Therapeutics.
[46] P. Riederer,et al. Aldehyde dehydrogenase (ALDH) in Alzheimer’s and Parkinson’s disease , 2016, Journal of Neural Transmission.
[47] Y. Sharabi,et al. DOPAL is transmissible to and oligomerizes alpha-synuclein in human glial cells , 2016, Autonomic Neuroscience.
[48] Jacqueline Burré. The Synaptic Function of α-Synuclein , 2015, Journal of Parkinson's disease.
[49] Jun B. Ding,et al. Aldehyde dehydrogenase 1a1 mediates a GABA synthesis pathway in midbrain dopaminergic neurons , 2015, Science.
[50] D. Eliezer,et al. Oligomerization and Membrane-binding Properties of Covalent Adducts Formed by the Interaction of α-Synuclein with the Toxic Dopamine Metabolite 3,4-Dihydroxyphenylacetaldehyde (DOPAL)* , 2015, The Journal of Biological Chemistry.
[51] Xiong Zhang,et al. Aldehyde dehydrogenase 2 genetic variations may increase susceptibility to Parkinson's disease in Han Chinese population , 2015, Neurobiology of Aging.
[52] L. Bubacco,et al. Analysis of the Catecholaminergic Phenotype in Human SH-SY5Y and BE(2)-M17 Neuroblastoma Cell Lines upon Differentiation , 2015, PloS one.
[53] D. Selkoe,et al. KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity , 2015, Proceedings of the National Academy of Sciences.
[54] A. M. Ribeiro,et al. Molecular, Neurochemical, and Behavioral Hallmarks of Reserpine as a Model for Parkinson's Disease: New Perspectives to a Long‐Standing Model , 2015, Brain pathology.
[55] D. Lovinger,et al. Selective expression of Parkinson's disease-related Leucine-rich repeat kinase 2 G2019S missense mutation in midbrain dopaminergic neurons impairs dopamine release and dopaminergic gene expression. , 2015, Human molecular genetics.
[56] D. Mash,et al. Decreased vesicular storage and aldehyde dehydrogenase activity in multiple system atrophy. , 2015, Parkinsonism & related disorders.
[57] J. Goudreau,et al. Methylmercury impairs canonical dopamine metabolism in rat undifferentiated pheochromocytoma (PC12) cells by indirect inhibition of aldehyde dehydrogenase. , 2015, Toxicological sciences : an official journal of the Society of Toxicology.
[58] S. Kügler,et al. Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation , 2015, Acta Neuropathologica.
[59] C. van Broeckhoven,et al. Progress in unraveling the genetic etiology of Parkinson disease in a genomic era. , 2015, Trends in genetics : TIG.
[60] Matthew R. Pratt,et al. Extent of inhibition of α-synuclein aggregation in vitro by SUMOylation is conjugation site- and SUMO isoform-selective. , 2015, Biochemistry.
[61] P. Greengard,et al. Molecular determinants of selective dopaminergic vulnerability in Parkinson’s disease: an update , 2014, Front. Neuroanat..
[62] H. Cai,et al. Aldehyde Dehydrogenase 1 making molecular inroads into the differential vulnerability of nigrostriatal dopaminergic neuron subtypes in Parkinson’s disease , 2014, Translational Neurodegeneration.
[63] D. Goldstein,et al. Catecholamine autotoxicity. Implications for pharmacology and therapeutics of Parkinson disease and related disorders. , 2014, Pharmacology & therapeutics.
[64] A. Xu,et al. Functional polymorphisms of the MAO gene with Parkinson disease susceptibility: A meta-analysis , 2014, Journal of the Neurological Sciences.
[65] D. Mochly‐Rosen,et al. Neuroprotective effects of aldehyde dehydrogenase 2 activation in rotenone-induced cellular and animal models of parkinsonism , 2014, Experimental Neurology.
[66] G. Braus,et al. Interplay between Sumoylation and Phosphorylation for Protection against α-Synuclein Inclusions* , 2014, The Journal of Biological Chemistry.
[67] J. Casida,et al. Benomyl, Aldehyde Dehydrogenase, DOPAL, and the Catecholaldehyde Hypothesis for the Pathogenesis of Parkinson’s Disease , 2014, Chemical research in toxicology.
[68] H. Cai,et al. Aldehyde dehydrogenase 1 defines and protects a nigrostriatal dopaminergic neuron subpopulation. , 2014, The Journal of clinical investigation.
[69] C. Cavada,et al. Is Parkinson's Disease a Vesicular Dopamine Storage Disorder? Evidence from a Study in Isolated Synaptic Vesicles of Human and Nonhuman Primate Striatum , 2014, The Journal of Neuroscience.
[70] H. Urlaub,et al. Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins , 2014, Science.
[71] D. Goldstein,et al. Divalent metal ions enhance DOPAL-induced oligomerization of alpha-synuclein , 2014, Neuroscience Letters.
[72] D. D. Di Monte,et al. Metformin lowers Ser-129 phosphorylated α-synuclein levels via mTOR-dependent protein phosphatase 2A activation , 2014, Cell Death and Disease.
[73] B. Ritz,et al. Aldehyde dehydrogenase variation enhances effect of pesticides associated with Parkinson disease , 2014, Neurology.
[74] Luigi Bubacco,et al. Are dopamine derivatives implicated in the pathogenesis of Parkinson's disease? , 2014, Ageing Research Reviews.
[75] A. Björklund,et al. NURR1 in Parkinson disease—from pathogenesis to therapeutic potential , 2013, Nature Reviews Neurology.
[76] Richard Wade-Martins,et al. Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model , 2013, Proceedings of the National Academy of Sciences.
[77] J. R. Santos,et al. Cognitive, motor and tyrosine hydroxylase temporal impairment in a model of parkinsonism induced by reserpine , 2013, Behavioural Brain Research.
[78] D. Mash,et al. Determinants of buildup of the toxic dopamine metabolite DOPAL in Parkinson's disease , 2013, Journal of neurochemistry.
[79] S. Goldwurm,et al. Analysis of vesicular monoamine transporter 2 polymorphisms in Parkinson’s disease , 2013, Neurobiology of Aging.
[80] Daniel Weindl,et al. Complexity of dopamine metabolism , 2013, Cell Communication and Signaling.
[81] L. Bubacco,et al. Dysfunction of dopamine homeostasis: clues in the hunt for novel Parkinson's disease therapies , 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[82] D. Surmeier,et al. Neuronal vulnerability, pathogenesis, and Parkinson's disease , 2013, Movement disorders : official journal of the Movement Disorder Society.
[83] B. Ritz,et al. Aldehyde dehydrogenase inhibition as a pathogenic mechanism in Parkinson disease , 2012, Proceedings of the National Academy of Sciences.
[84] D. Goldstein,et al. Vesicular uptake blockade generates the toxic dopamine metabolite 3,4‐dihydroxyphenylacetaldehyde in PC12 cells: relevance to the pathogenesis of Parkinson's disease , 2012, Journal of neurochemistry.
[85] J. Doorn,et al. Catechol and aldehyde moieties of 3,4-dihydroxyphenylacetaldehyde contribute to tyrosine hydroxylase inhibition and neurotoxicity , 2012, Brain Research.
[86] B. Sabatini,et al. Dopaminergic neurons inhibit striatal output via non-canonical release of GABA , 2012, Nature.
[87] D. Lovinger,et al. Conditional Expression of Parkinson's Disease-Related Mutant α-Synuclein in the Midbrain Dopaminergic Neurons Causes Progressive Neurodegeneration and Degradation of Transcription Factor Nuclear Receptor Related 1 , 2012, The Journal of Neuroscience.
[88] Vindhya Koppaka,et al. Aldehyde Dehydrogenase Inhibitors: a Comprehensive Review of the Pharmacology, Mechanism of Action, Substrate Specificity, and Clinical Application , 2012, Pharmacological Reviews.
[89] D. Goldstein,et al. Neurodegeneration and Motor Dysfunction in Mice Lacking Cytosolic and Mitochondrial Aldehyde Dehydrogenases: Implications for Parkinson's Disease , 2012, PloS one.
[90] C. Perrone-Capano,et al. Direct Regulation of Pitx3 Expression by Nurr1 in Culture and in Developing Mouse Midbrain , 2012, PloS one.
[91] J. Schneider,et al. Functional significance of aldehyde dehydrogenase ALDH1A1 to the nigrostriatal dopamine system , 2011, Brain Research.
[92] Y. Sharabi,et al. Intra-neuronal vesicular uptake of catecholamines is decreased in patients with Lewy body diseases. , 2011, The Journal of clinical investigation.
[93] J. Doorn,et al. Inhibition and covalent modification of tyrosine hydroxylase by 3,4-dihydroxyphenylacetaldehyde, a toxic dopamine metabolite. , 2011, Neurotoxicology.
[94] J. Doorn,et al. Oxidation of 3,4-Dihydroxyphenylacetaldehyde, a Toxic Dopaminergic Metabolite, to a Semiquinone Radical and an ortho-Quinone* , 2011, The Journal of Biological Chemistry.
[95] Richard Wade-Martins,et al. Functional Alterations to the Nigrostriatal System in Mice Lacking All Three Members of the Synuclein Family , 2011, The Journal of Neuroscience.
[96] D. Goldstein,et al. Catechols in post‐mortem brain of patients with Parkinson disease , 2011, European journal of neurology.
[97] Beate Ritz,et al. Parkinson’s disease risk from ambient exposure to pesticides , 2011, European Journal of Epidemiology.
[98] Fred H. Gage,et al. In vivo demonstration that α-synuclein oligomers are toxic , 2011, Proceedings of the National Academy of Sciences.
[99] W. Burke,et al. The Neurotoxicity of DOPAL: Behavioral and Stereological Evidence for Its Role in Parkinson Disease Pathogenesis , 2010, PloS one.
[100] T. Südhof,et al. α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro , 2010, Science.
[101] L. Bubacco,et al. Molecular characterization of dopamine-derived quinones reactivity toward NADH and glutathione: implications for mitochondrial dysfunction in Parkinson disease. , 2010, Biochimica et biophysica acta.
[102] J. Henley,et al. Mechanisms, regulation and consequences of protein SUMOylation. , 2010, The Biochemical journal.
[103] D. Mochly‐Rosen,et al. Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant , 2010, Nature Structural &Molecular Biology.
[104] R. Nicoll,et al. Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis , 2010, Neuron.
[105] R. Seegal,et al. Methylmercury inhibits dopaminergic function in rat pup synaptosomes in an age-dependent manner. , 2009, Neurotoxicology and teratology.
[106] J. Doorn,et al. Protein reactivity of 3,4-dihydroxyphenylacetaldehyde, a toxic dopamine metabolite, is dependent on both the aldehyde and the catechol. , 2009, Chemical research in toxicology.
[107] M. Cascio,et al. Proteomic identification of dopamine-conjugated proteins from isolated rat brain mitochondria and SH-SY5Y cells , 2009, Neurobiology of Disease.
[108] S. Strack,et al. Products of oxidative stress inhibit aldehyde oxidation and reduction pathways in dopamine catabolism yielding elevated levels of a reactive intermediate. , 2009, Chemical research in toxicology.
[109] D. Krainc,et al. Acetylation Targets Mutant Huntingtin to Autophagosomes for Degradation , 2009, Cell.
[110] Min Zhang,et al. Molecular Cloning and Oxidative Modification of Human Lens ALDH1A1: Implication in Impaired Detoxification of Lipid Aldehydes , 2009, Journal of toxicology and environmental health. Part A.
[111] M. Chesselet,et al. Ziram Causes Dopaminergic Cell Damage by Inhibiting E1 Ligase of the Proteasome* , 2008, Journal of Biological Chemistry.
[112] M. Disatnik,et al. Activation of Aldehyde Dehydrogenase-2 Reduces Ischemic Damage to the Heart , 2008, Science.
[113] C. Brocker,et al. Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily , 2008, Expert opinion on drug metabolism & toxicology.
[114] J. Andersen,et al. MAO-B Elevation in Mouse Brain Astrocytes Results in Parkinson's Pathology , 2008, PloS one.
[115] Cornelius J Werner,et al. Proteome analysis of human substantia nigra in Parkinson's disease , 2008, Proteome Science.
[116] S. Cragg,et al. Increased striatal dopamine release and hyperdopaminergic‐like behaviour in mice lacking both alpha‐synuclein and gamma‐synuclein , 2008, The European journal of neuroscience.
[117] W. Burke,et al. Aggregation of α-synuclein by DOPAL, the monoamine oxidase metabolite of dopamine , 2008, Acta Neuropathologica.
[118] B. Cagniard,et al. Unregulated Cytosolic Dopamine Causes Neurodegeneration Associated with Oxidative Stress in Mice , 2008, The Journal of Neuroscience.
[119] J. Doorn,et al. Lipid peroxidation products inhibit dopamine catabolism yielding aberrant levels of a reactive intermediate. , 2007, Chemical research in toxicology.
[120] Gary W. Miller,et al. Reduced Vesicular Storage of Dopamine Causes Progressive Nigrostriatal Neurodegeneration , 2007, The Journal of Neuroscience.
[121] M. Smidt,et al. Retinoic acid counteracts developmental defects in the substantia nigra caused by Pitx3 deficiency , 2007, Development.
[122] V. Vasiliou,et al. Neurotoxicity and Metabolism of the Catecholamine-Derived 3,4-Dihydroxyphenylacetaldehyde and 3,4-Dihydroxyphenylglycolaldehyde: The Role of Aldehyde Dehydrogenase , 2007, Pharmacological Reviews.
[123] J. Mellor,et al. SUMOylation regulates kainate-receptor-mediated synaptic transmission , 2007, Nature.
[124] D. Sulzer,et al. Multiple hit hypotheses for dopamine neuron loss in Parkinson's disease , 2007, Trends in Neurosciences.
[125] L. Moran,et al. The medial and lateral substantia nigra in Parkinson’s disease: mRNA profiles associated with higher brain tissue vulnerability , 2007, Neurogenetics.
[126] G. Gerhardt,et al. Monoamine metabolism and behavioral responses to ethanol in mitochondrial aldehyde dehydrogenase knockout mice. , 2006, Alcoholism, clinical and experimental research.
[127] P. Carvey,et al. Progressive Dopamine Neuron Loss in Parkinson's Disease: The Multiple Hit Hypothesis , 2006, Cell transplantation.
[128] D. Selkoe,et al. Dopamine covalently modifies and functionally inactivates parkin , 2005, Nature Medicine.
[129] Vellareddy Anantharam,et al. Dieldrin-induced neurotoxicity: relevance to Parkinson's disease pathogenesis. , 2005, Neurotoxicology.
[130] S. Mandel,et al. Gene expression profiling of parkinsonian substantia nigra pars compacta; alterations in ubiquitin-proteasome, heat shock protein, iron and oxidative stress regulated proteins, cell adhesion/cellular matrix and vesicle trafficking genes , 2004, Journal of Neural Transmission.
[131] J. Costentin,et al. Toxicity of a treatment associating dopamine and disulfiram for catecholaminergic neuroblastoma SH-SY5Y cells: relationships with 3,4-dihydroxyphenylacetaldehyde formation. , 2004, Neurotoxicology.
[132] V. Vasiliou,et al. Role of Human Aldehyde Dehydrogenases in Endobiotic and Xenobiotic Metabolism , 2004, Drug metabolism reviews.
[133] Dagmar Galter,et al. ALDH1 mRNA: presence in human dopamine neurons and decreases in substantia nigra in Parkinson's disease and in the ventral tegmental area in schizophrenia , 2003, Neurobiology of Disease.
[134] D. S. Zahm,et al. 3,4-Dihydroxyphenylacetaldehyde is the toxic dopamine metabolite in vivo: implications for Parkinson’s disease pathogenesis , 2003, Brain Research.
[135] V. Vasiliou,et al. Molecular cloning and baculovirus expression of the rabbit corneal aldehyde dehydrogenase (ALDH1A1) cDNA. , 2003, DNA and cell biology.
[136] Chris Zarow,et al. Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseases. , 2003, Archives of neurology.
[137] T. Fukagawa,et al. Ubc9 is essential for viability of higher eukaryotic cells. , 2002, Experimental cell research.
[138] Ted M. Dawson,et al. Neuroprotective and neurorestorative strategies for Parkinson's disease , 2002, Nature Neuroscience.
[139] E. Cochran,et al. Age‐related decreases in Nurr1 immunoreactivity in the human substantia nigra , 2002, The Journal of comparative neurology.
[140] W. Burke,et al. 3,4-Dihydroxyphenylacetaldehyde and hydrogen peroxide generate a hydroxyl radical: possible role in Parkinson's disease pathogenesis. , 2001, Brain research. Molecular brain research.
[141] W. Burke,et al. Selective dopaminergic vulnerability: 3,4-dihydroxyphenylacetaldehyde targets mitochondria. , 2001, Free radical biology & medicine.
[142] W. Keung,et al. The mitochondrial monoamine oxidase-aldehyde dehydrogenase pathway: a potential site of action of daidzin. , 2000, Journal of medicinal chemistry.
[143] V. Vasiliou,et al. Characterization of 4-hydroxy-2-nonenal metabolism in stellate cell lines derived from normal and cirrhotic rat liver. , 2000, Biochimica et biophysica acta.
[144] Graeme Eisenhofer,et al. 3,4-Dihydroxyphenylacetaldehyde potentiates the toxic effects of metabolic stress in PC12 cells , 2000, Brain Research.
[145] G. Eisenhofer,et al. Metabolic stress in PC12 cells induces the formation of the endogenous dopaminergic neurotoxin, 3,4‐dihydroxyphenylacetaldehyde , 2000, Journal of neuroscience research.
[146] R. F. Shore,et al. Diorthosubstituted Polychlorinated Biphenyls in Caudate Nucleus in Parkinson's Disease , 1998, Experimental Neurology.
[147] M. L. Schmidt,et al. α-Synuclein in Lewy bodies , 1997, Nature.
[148] E. Hirsch,et al. Does monoamine oxidase type B play a role in dopaminergic nerve cell death in Parkinson's disease? , 1996, Neurology.
[149] A. Klyosov,et al. Possible role of liver cytosolic and mitochondrial aldehyde dehydrogenases in acetaldehyde metabolism. , 1996, Biochemistry.
[150] N. Hattori,et al. Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[151] R. Strong,et al. An endogenous dopaminergic neurotoxin: implication for Parkinson's disease. , 1995, Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration.
[152] Akihiko Iwai,et al. The precursor protein of non-Aβ component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system , 1995, Neuron.
[153] U. Dräger,et al. High levels of a retinoic acid-generating dehydrogenase in the meso-telencephalic dopamine system. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[154] J. Kurth,et al. Association of a monoamine oxidase B allele with Parkinson's disease , 1993, Annals of neurology.
[155] R. Pietruszko,et al. Human aldehyde dehydrogenase. Activity with aldehyde metabolites of monoamines, diamines, and polyamines. , 1991, The Journal of biological chemistry.
[156] C. Marsden,et al. Increased Nigral Iron Content and Alterations in Other Metal Ions Occurring in Brain in Parkinson's Disease , 1989, Journal of neurochemistry.
[157] R. Pietruszko,et al. Human aldehyde dehydrogenase: metabolism of putrescine and histamine. , 1987, Alcoholism, clinical and experimental research.
[158] D. Petersen,et al. The oxidation of α-β unsaturated aldehydic products of lipid peroxidation by rat liver aldehyde dehydrogenases☆ , 1987 .
[159] Alexander D. MacKerell,et al. Chemical modification of human aldehyde dehydrogenase by physiological substrate. , 1987, Biochimica et biophysica acta.
[160] Alexander D. MacKerell,et al. Human aldehyde dehydrogenase: kinetic identification of the isozyme for which biogenic aldehydes and acetaldehyde compete. , 1986, Alcoholism, clinical and experimental research.
[161] Y. Agid,et al. Monoamine oxidase and aldehyde dehydrogenase activity in the striatum of rats after 6‐hydroxydopamine lesion of the nigrostriatal pathway , 1973, British journal of pharmacology.
[162] D. Eliezer,et al. Role of Parkinson’s Disease-linked Mutations and N-Terminal Acetylation on the Oligomerization of α -Synuclein Induced by DOPAL , 2019 .
[163] M. Khaniani,et al. Genetic Analysis of the ZNF512B, SLC41A1, and ALDH2 Polymorphisms in Parkinson's Disease in the Iranian Population. , 2016, Genetic testing and molecular biomarkers.
[164] Brigitte C Vanle,et al. Aldehyde dehydrogenase inhibition generates a reactive dopamine metabolite autotoxic to dopamine neurons. , 2014, Parkinsonism & related disorders.
[165] T. Nickl-Jockschat,et al. Aldehyde dehydrogenase 2 in sporadic Parkinson's disease. , 2014, Parkinsonism & related disorders.
[166] J. Doorn,et al. Inhibition of the oxidative metabolism of 3,4-dihydroxyphenylacetaldehyde, a reactive intermediate of dopamine metabolism, by 4-hydroxy-2-nonenal. , 2007, Neurotoxicology.
[167] S. Mandel,et al. Gene and protein signatures in sporadic Parkinson's disease and a novel genetic model of PD. , 2007, Parkinsonism & related disorders.
[168] H. Parvez,et al. Monoamine oxidase expression during development and aging. , 2004, Neurotoxicology.
[169] Hilde van der Togt,et al. Publisher's Note , 2003, J. Netw. Comput. Appl..
[170] R. Holmes,et al. Human corneal and lens aldehyde dehydrogenases. Purification and properties of human lens ALDH1 and differential expression as major soluble proteins in human lens (ALDH1) and cornea (ALDH3). , 1997, Advances in experimental medicine and biology.
[171] A. Yoshida,et al. Retinal oxidation activity and biological role of human cytosolic aldehyde dehydrogenase. , 1992, Enzyme.
[172] D. Petersen,et al. The oxidation of alpha-beta unsaturated aldehydic products of lipid peroxidation by rat liver aldehyde dehydrogenases. , 1987, Toxicology and applied pharmacology.