Tranilast attenuates connective tissue growth factor-induced extracellular matrix accumulation in renal cells.

[1]  R. Gilbert,et al.  Integrated actions of transforming growth factor-beta1 and connective tissue growth factor in renal fibrosis. , 2005, American journal of physiology. Renal physiology.

[2]  Yuan Zhang,et al.  Intervention with Tranilast Attenuates Renal Pathology and Albuminuria in Advanced Experimental Diabetic Nephropathy , 2003, Nephron Physiology.

[3]  T. Sugawara,et al.  Tranilast Slows the Progression of Advanced Diabetic Nephropathy , 2002, Nephron.

[4]  E. Robertis,et al.  Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-β , 2002, Nature Cell Biology.

[5]  M. Ward,et al.  Tranilast Prevents Activation of Transforming Growth Factor-&bgr; System, Leukocyte Accumulation, and Neointimal Growth in Porcine Coronary Arteries After Stenting , 2002, Arteriosclerosis, thrombosis, and vascular biology.

[6]  J. Yates,et al.  The Low Density Lipoprotein Receptor-related Protein/α2-Macroglobulin Receptor Is a Receptor for Connective Tissue Growth Factor* , 2001, The Journal of Biological Chemistry.

[7]  H. Ochiai,et al.  Tranilast inhibits TGF- A1 secretion without affecting its mRNA levels in conjunctival cells. , 2001, The Kobe journal of medical sciences.

[8]  H. Yokoi,et al.  Role of connective tissue growth factor in profibrotic action of transforming growth factor-beta: a potential target for preventing renal fibrosis. , 2001, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[9]  T. Saruta,et al.  Tranilast inhibits interleukin-1beta-induced monocyte chemoattractant protein-1 expression in rat mesangial cells. , 2001, European journal of pharmacology.

[10]  M. Pfaffl,et al.  A new mathematical model for relative quantification in real-time RT-PCR. , 2001, Nucleic acids research.

[11]  T. Asano,et al.  Tranilast ameliorates renal tubular damage in unilateral ureteral obstruction. , 2001, The Journal of urology.

[12]  F. Strutz,et al.  TGF-beta 1 induces proliferation in human renal fibroblasts via induction of basic fibroblast growth factor (FGF-2). , 2001, Kidney international.

[13]  W. B. Reeves,et al.  Transforming growth factor β contributes to progressive diabetic nephropathy , 2000 .

[14]  C. Pollock,et al.  High glucose increases growth and collagen synthesis in cultured human tubulointerstitial cells , 1999, Diabetic medicine : a journal of the British Diabetic Association.

[15]  David W. Johnson,et al.  Fibrogenic Effects of Cyclosporin A on the Tubulointerstitium: Role of Cytokines and Growth Factors , 1999, Nephron Experimental Nephrology.

[16]  M. Murphy,et al.  Connective tissue growth factor: a potential stimulus for glomerulosclerosis and tubulointerstitial fibrosis in progressive renal disease. , 1999, Current opinion in nephrology and hypertension.

[17]  W. Qi,et al.  Intermittent high glucose enhances cell growth and collagen synthesis in cultured human tubulointerstitial cells , 1999, Diabetologia.

[18]  McDonald,et al.  Nuclear expression of p53, p21 and cyclin D1 is increased in bronchioloalveolar carcinoma , 1999, Histopathology.

[19]  R. Baxter,et al.  Paracrine stimulation of human renal fibroblasts by proximal tubule cells. , 1998, Kidney international.

[20]  H. Miyata,et al.  Inhibition by tranilast of vascular endothelial growth factor (VEGF)/vascular permeability factor (VPF)-induced increase in vascular permeability in rats. , 1998, Life sciences.

[21]  M. Ward,et al.  Inhibitory effects of tranilast on expression of transforming growth factor-beta isoforms and receptors in injured arteries. , 1998, Atherosclerosis.

[22]  R. Baxter,et al.  Human renal fibroblasts modulate proximal tubule cell growth and transport via the IGF-I axis. , 1997, Kidney international.

[23]  T. V. Kolesnikova,et al.  Cyr61 and Fisp12 are both ECM-associated signaling molecules: activities, metabolism, and localization during development. , 1997, Experimental cell research.

[24]  W. Border,et al.  TGF-β in kidney fibrosis: A target for gene therapy , 1997 .

[25]  T. Nishikawa,et al.  Tranilast, a selective inhibitor of collagen synthesis in human skin fibroblasts. , 1994, Journal of Biochemistry (Tokyo).

[26]  T. Yorifuji,et al.  Treatment of linear localized scleroderma with the anti‐allergic drug, tranilast , 1994, Clinical and experimental dermatology.

[27]  M. Ketteler,et al.  Increased expression of transforming growth factor-beta in renal disease. , 1994, Current opinion in nephrology and hypertension.

[28]  A. Koda,et al.  The mechanism involved in the inhibitory action of tranilast on collagen biosynthesis of keloid fibroblasts. , 1993, Japanese journal of pharmacology.

[29]  M. Okuda,et al.  A clinical evaluation of N-5' with perennial-type allergic rhinitis--a test by the multi-clinic, intergroup, double-blind comparative method. , 1984, Annals of allergy.

[30]  A. Phillips,et al.  Diabetic nephropathy: the central role of renal proximal tubular cells in tubulointerstitial injury. , 2002, Histology and histopathology.

[31]  D. Basile,et al.  The transforming growth factor beta system in kidney disease and repair: recent progress and future directions. , 1999, Current opinion in nephrology and hypertension.

[32]  K. Miyazawa,et al.  Inhibitory effects of tranilast on proliferation, migration, and collagen synthesis of human vascular smooth muscle cells. , 1996, Canadian journal of physiology and pharmacology.

[33]  J. Norman,et al.  Cellular events in renal hypertrophy. , 1989, Annual review of physiology.