Automated Sleep Stage Scoring Using k-Nearest Neighbors Classifier

Many features of sleep, such as the existence of rapid eye movement (REM) sleep or non-REM sleep stages, as well as some of the underlying physiological mechanisms controlling sleep, are conserved across different mammalian species. Sleep research is important to understanding the impact of disease on circadian biology and optimal waking performance, and to advance treatments for sleep disorders, such as narcolepsy, shift work disorder, non-24 sleep-wake disorder, and neurodegenerative disease. Given the evolutionary relatedness of mammalian species, sleep architecture and changes therein may provide reliable translational biomarkers for pharmacological engagement in proof-of-mechanism clinical studies.

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