IL-1β induced protein changes in diabetes prone BB rat islets of Langerhans identified by proteome analysis

[1]  T. Mandrup-Poulsen,et al.  The role of interleukin-1 in the pathogenesis of IDDM , 1996, Diabetologia.

[2]  F. Pociot,et al.  On the pathogenesis of IDDM , 1994, Diabetologia.

[3]  J. Nerup,et al.  Heat shock protein induction in rat pancreatic islets by recombinant human interleukin 1β , 1991, Diabetologia.

[4]  A. Rabinovitch,et al.  Oxygen free radical scavengers protect rat islet cells from damage by cytokines , 1989, Diabetologia.

[5]  J. Nerup,et al.  Interleukin 1 dose-dependently affects the biosynthesis of (pro)insulin in isolated rat islets of Langerhans , 1987, Diabetologia.

[6]  F. Miró,et al.  Association of protein kinase CK2 with eukaryotic translation initiation factor eIF-2 and with grp94/endoplasmin , 2004, Molecular and Cellular Biochemistry.

[7]  F. Pociot,et al.  Combined genome and proteome approach to identify new susceptibility genes. , 2002, American journal of medical genetics.

[8]  M. Kruhøffer,et al.  Identification of novel cytokine-induced genes in pancreatic beta-cells by high-density oligonucleotide arrays. , 2001, Diabetes.

[9]  F. Pociot,et al.  Proteome analysis of interleukin-1beta--induced changes in protein expression in rat islets of Langerhans. , 2001, Diabetes.

[10]  M. Ashby,et al.  ER calcium and the functions of intracellular organelles. , 2001, Seminars in cell & developmental biology.

[11]  G. L. Miklos,et al.  Protein functions and biological contexts , 2001, Proteomics.

[12]  M. Berridge,et al.  Calcium signalling--an overview. , 2001, Seminars in cell & developmental biology.

[13]  D. Speicher,et al.  Two‐Dimensional Gel Electrophoresis , 1998, Current protocols in protein science.

[14]  Y. Tsujimoto,et al.  VDAC regulation by the Bcl-2 family of proteins , 2000, Cell Death and Differentiation.

[15]  J. Eaton,et al.  Hereditary catalase deficiencies and increased risk of diabetes , 2000, The Lancet.

[16]  S. Kash,et al.  Does GAD have a unique role in triggering IDDM? , 2000, Journal of autoimmunity.

[17]  F. Pociot,et al.  Cytokine- or chemically derived nitric oxide alters the expression of proteins detected by two-dimensional gel electrophoresis in neonatal rat islets of Langerhans. , 2000, Diabetes.

[18]  W. Waldhäusl,et al.  Cloning and Expression of Secretagogin, a Novel Neuroendocrine- and Pancreatic Islet of Langerhans-specific Ca2+-binding Protein* , 2000, The Journal of Biological Chemistry.

[19]  J. Nerup,et al.  Protection of insulin-producing RINm5F cells against cytokine-mediated toxicity through overexpression of antioxidant enzymes. , 2000, Diabetes.

[20]  K. Bendtzen,et al.  Massive parallel gene expression profiling of RINm5F pancreatic islet β‐cells stimulated with interleukin‐1β , 2000 .

[21]  H. Langen,et al.  Mass spectrometry: A tool for the identification of proteins separated by gels , 2000, Electrophoresis.

[22]  J. Nerup,et al.  Islet Protein Expression Changes during Diabetes Development in Islet Syngrafts in BB-DP Rats and during Rejection of BB-DP Islet Allografts , 2000, Autoimmunity.

[23]  D. Pipeleers,et al.  IL-1beta induces serine protease inhibitor 3 (SPI-3) gene expression in rat pancreatic beta-cells. Detection by differential display of messenger RNA. , 1999, Cytokine.

[24]  G. Hendy,et al.  Peptide hormone precursor processing: getting sorted? , 1999, Molecular and Cellular Endocrinology.

[25]  Y. Moriwaki,et al.  Enzymes involved in purine metabolism--a review of histochemical localization and functional implications. , 1999, Histology and histopathology.

[26]  F. Pociot,et al.  Onset of type 1 diabetes: a dynamical instability. , 1999, Diabetes.

[27]  T. Diekwisch,et al.  Cloning, gene expression, and characterization of CP27, a novel gene in mouse embryogenesis. , 1999, Gene.

[28]  D. Eizirik,et al.  Exposure of human islets to cytokines can result in disproportionately elevated proinsulin release. , 1999, The Journal of clinical investigation.

[29]  Masashi Narita,et al.  Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC , 1999, Nature.

[30]  R. Munday,et al.  Protection against the co-operative toxicity of nitric oxide and oxygen free radicals by overexpression of antioxidant enzymes in bioengineered insulin-producing RINm5F cells , 1999, Diabetologia.

[31]  L. Tjernberg,et al.  Binding of amyloid β‐peptide to mitochondrial hydroxyacyl‐CoA dehydrogenase (ERAB): regulation of an SDR enzyme activity with implications for apoptosis in Alzheimer's disease , 1999 .

[32]  Jung‐Ta Chen,et al.  Galectin‐3 expression is induced in cirrhotic liver and hepatocellular carcinoma , 1999, International journal of cancer.

[33]  S. Baekkeskov,et al.  Glutamate Decarboxylase and GABA in Pancreatic Islets: Lessons from Knock-Out Mice , 1999, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[34]  S. Gygi,et al.  Correlation between Protein and mRNA Abundance in Yeast , 1999, Molecular and Cellular Biology.

[35]  I. Athanassakis,et al.  The destructive action of IL-1alpha and IL-1beta in IDDM is a multistage process: evidence and confirmation by apoptotic studies, induction of intermediates and electron microscopy. , 1999, Mediators of inflammation.

[36]  P. Roepstorff,et al.  Mass spectrometric identification and microcharacterization of proteins from electrophoretic gels: Strategies and applications , 1998, Proteins.

[37]  J. Corbett,et al.  Heat Shock Inhibits Cytokine-Induced Nitric Oxide Synthase Expression by Rat and Human Islets* * This work was supported by research grants from the NIH (DK-52194) and The Tobacco Research Council. , 1998, Endocrinology.

[38]  J. Nerup,et al.  Interleukin‐1β induced changes in the protein expression of rat islets: A computerized database , 1997 .

[39]  Martin Kussmann,et al.  Matrix‐assisted Laser Desorption/Ionization Mass Spectrometry Sample Preparation Techniques Designed for Various Peptide and Protein Analytes , 1997 .

[40]  M. Colombini,et al.  Regulation of Metabolite Flux through Voltage-Gating of VDAC Channels , 1997, The Journal of Membrane Biology.

[41]  G. Clark,et al.  Isolation and characterization of a novel gene induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat liver , 1997 .

[42]  H. Kolb,et al.  Low Stress Response Enhances Vulnerability of Islet Cells in Diabetes-Prone BB Rats , 1997, Diabetes.

[43]  A. Schönthal,et al.  Endoplasmic reticulum stress‐inducible protein GRP94 is associated with an Mg2+‐dependent serine kinase activity modulated by Ca2+ and GRP78/BiP , 1997, Journal of cellular physiology.

[44]  S. High,et al.  Interaction of the Thiol-Dependent Reductase ERp57 with Nascent Glycoproteins , 1997, Science.

[45]  A. Görg,et al.  Proteome analysis of Saccharomyces cerevisiae: A methodological outline , 1997, Electrophoresis.

[46]  G. Clark,et al.  Isolation and characterization of a novel gene induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat liver. , 1996, Carcinogenesis.

[47]  H. Kolb,et al.  Heat shock protein hsp70 overexpression confers resistance against nitric oxide , 1996, FEBS letters.

[48]  F. Pociot,et al.  Strain-dependent differences in sensitivity of rat beta-cells to interleukin 1 beta in vitro and in vivo: association with islet nitric oxide synthesis. , 1996, Diabetes.

[49]  D. Steiner,et al.  The role of prohormone convertases in insulin biosynthesis: evidence for inherited defects in their action in man and experimental animals. , 1996, Diabetes & metabolism.

[50]  A. Shevchenko,et al.  Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. , 1996, Analytical chemistry.

[51]  S. Hockfield,et al.  TOAD-64, a gene expressed early in neuronal differentiation in the rat, is related to unc-33, a C. elegans gene involved in axon outgrowth , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[52]  Keiichiro Suzuki,et al.  Apoptotic Cell Death Triggered by Nitric Oxide in Pancreatic β-Cells , 1995, Diabetes.

[53]  M. Mcdaniel,et al.  Intraislet release of interleukin 1 inhibits beta cell function by inducing beta cell expression of inducible nitric oxide synthase , 1995, The Journal of experimental medicine.

[54]  Y. Nakamura,et al.  Isolation and mapping of the human EIF4A2 gene homologous to the murine protein synthesis initiation factor 4A-II gene Eif4a2. , 1995, Cytogenetics and cell genetics.

[55]  J. Palmer,et al.  The effect of cytokines on expression of glutamic acid decarboxylase-65 in cultured islets. , 1995, Autoimmunity.

[56]  M. Mcdaniel,et al.  Intraislet Release of Interleukin 1 Inhibits 3 Cell Function by Inducing 3 Cell Expression of Inducible Nitric Oxide Synthase , 1995 .

[57]  B. Brüne,et al.  Interleukin-1 beta-induced nitric oxide production activates apoptosis in pancreatic RINm5F cells. , 1994, Experimental cell research.

[58]  S. Riva,et al.  Two homologous genes, originated by duplication, encode the human hnRNP proteins A2 and A1. , 1994, Nucleic acids research.

[59]  V. Valentine,et al.  Localization of the gene encoding human BiP/GRP78, the endoplasmic reticulum cognate of the HSP70 family, to chromosome 9q34. , 1994, Genomics.

[60]  M. Shago,et al.  Inhibition of nuclear hormone receptor activity by calreticulin , 1994, Nature.

[61]  K. Burns,et al.  Modulation of gene expression by calreticulin binding to the glucocorticoid receptor , 1994, Nature.

[62]  F. Pociot,et al.  Genetic susceptibility markers in Danish patients with type 1 (insulin-dependent) diabetes : evidence for polygenecity in man , 1994 .

[63]  F. Pociot,et al.  Genetic susceptibility markers in Danish patients with type 1 (insulin-dependent) diabetes--evidence for polygenicity in man. Danish Study Group of Diabetes in Childhood. , 1994, Autoimmunity.

[64]  F. Pociot,et al.  A manganese superoxide dismutase (SOD2) gene polymorphism in insulin-dependent diabetes mellitus. , 1993, Disease markers.

[65]  G. Sandford,et al.  Characterization of the major locus of immediate-early genes of rat cytomegalovirus , 1993, Journal of virology.

[66]  P. Højrup,et al.  Use of mass spectrometric molecular weight information to identify proteins in sequence databases. , 1993, Biological mass spectrometry.

[67]  Edward A. Lee,et al.  Decreased expression of Mac-2 (carbohydrate binding protein 35) and loss of its nuclear localization are associated with the neoplastic progression of colon carcinoma. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[68]  G. Dreyfuss,et al.  The human hnRNP M proteins: identification of a methionine/arginine-rich repeat motif in ribonucleoproteins. , 1993, Nucleic acids research.

[69]  N. Welsh,et al.  Interleukin‐1 ‐induced expression of nitric oxide synthase in insulin‐producing cells is preceded by c‐fos induction and depends on gene transcription and protein synthesis , 1993, FEBS letters.

[70]  P Ferrara,et al.  In-gel digestion of proteins for internal sequence analysis after one- or two-dimensional gel electrophoresis. , 1992, Analytical biochemistry.

[71]  E. Cagliero,et al.  Interleukin-1 beta increases the activity of superoxide dismutase in rat pancreatic islets. , 1992, Endocrinology.

[72]  J. Dixon,et al.  De novo purine nucleotide biosynthesis. , 1992, Progress in nucleic acid research and molecular biology.

[73]  S. Uhlig,et al.  The physiological consequences of glutathione variations. , 1992, Life sciences.

[74]  N. Welsh,et al.  Interleukin-1 beta-induced nitric oxide production in isolated rat pancreatic islets requires gene transcription and may lead to inhibition of the Krebs cycle enzyme aconitase. , 1991, Endocrinology.

[75]  M. Mcdaniel,et al.  Interleukin-1 beta-induced formation of EPR-detectable iron-nitrosyl complexes in islets of Langerhans. Role of nitric oxide in interleukin-1 beta-induced inhibition of insulin secretion. , 1991, The Journal of biological chemistry.

[76]  D. Adler,et al.  Cloning and primary structure of a human islet isoform of glutamic acid decarboxylase from chromosome 10. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[77]  M. Nakamura,et al.  A new membrane-associated Ca(2+)-binding protein of rat spermatogenic cells: its purification and characterization. , 1991, Biochemical and biophysical research communications.

[78]  N. Welsh,et al.  Influence of Protease on Inhibitory and Stimulatory Effects of Interleukin 1β on β-Cell Function , 1991, Diabetes.

[79]  J. Nerup,et al.  Heat shock protein induction in rat pancreatic islets by recombinant human interleukin 1 beta. , 1991, Diabetologia.

[80]  N. Welsh,et al.  Influence of protease on inhibitory and stimulatory effects of interleukin 1 beta on beta-cell function. , 1991, Diabetes.

[81]  S. Baekkeskov,et al.  Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase , 1990, Nature.

[82]  J. Nerup,et al.  Genetically determined differences in newborn rat islet sensitivity to interleukin-1 in vitro: no association with the diabetes prone phenotype in the BB-rat. , 1989, Acta endocrinologica.

[83]  K. Asayama,et al.  Effect of vitamin E deficiency and selenium deficiency on insulin secretory reserve and free radical scavenging systems in islets: decrease of islet manganosuperoxide dismutase. , 1986, The Journal of laboratory and clinical medicine.

[84]  J. Nerup,et al.  An autopsy study of the islets of Langerhans in acute-onset juvenile diabetes mellitus. , 2009, Acta pathologica et microbiologica Scandinavica. Section A, Pathology.

[85]  Howard M. Goodman,et al.  High resolution two-dimensional electrophoresis of basic as well as acidic proteins , 1977, Cell.

[86]  E. Marliss,et al.  The Spontaneously Diabetic Wistar Rat: Metabolic and Morphologic Studies , 1977, Diabetes.

[87]  W. Gepts.  Pathologic Anatomy of the Pancreas in Juvenile Diabetes Mellitus , 1965, Diabetes.