Itraconazole (Sporanox®) for vulvovaginal candidiasis.

Vulvovaginal candidiasis is a common occurrence among women over 25 years of age. The likelihood of developing infection increases with pregnancy, the use of oral contraceptives or antibiotics, or immune disorders. However, in many cases, the etiology of the disorder is unknown. Sobel1 suggests that some cases of reinfection may actually be cases of relapse, due to either inadequate testing methods, which result in false-negative results after treatment, or to ineffective treatments. Misdiagnosis of the causative organism may also result in ineffective treatment. The most common causal Candida species is C. albicans. However, other, less easily eradicated species may also be involved.

[1]  M. Barbareschi,et al.  Itraconazole: new horizons , 2002 .

[2]  G. Ricci,et al.  Efficacy of maintenance therapy with topical boric acid in comparison with oral itraconazole in the treatment of recurrent vulvovaginal candidiasis. , 2001, American journal of obstetrics and gynecology.

[3]  R. Summerbell,et al.  Prevalence and epidemiology of onychomycosis in patients visiting physicians' offices: a multicenter canadian survey of 15,000 patients. , 2000, Journal of the American Academy of Dermatology.

[4]  E. Ringdahl Treatment of recurrent vulvovaginal candidiasis. , 2000, American family physician.

[5]  A. Gupta,et al.  Itraconazole and terbinafine in perspective. From petri dish to patient. , 1999, Postgraduate medicine.

[6]  P. De Doncker Itraconazole and terbinafine in perspective: from petri dish to patient. , 1999, Journal of the European Academy of Dermatology and Venereology : JEADV.

[7]  T. Tamaya,et al.  Comparative Study on the Effectiveness of Antifungal Agents in Different Regimens against Vaginal Candidiasis , 1998, Chemotherapy.

[8]  C. R. Daniel,et al.  Itraconazole for the treatment of onychomycosis. , 1998, International journal of dermatology.

[9]  P. Stoffels,et al.  Itraconazole pulse therapy for onychomycosis and dermatomycoses: an overview. , 1997, Journal of the American Academy of Dermatology.

[10]  W. Chaim Fungal vaginitis caused by nonalbicans species. , 1997, American journal of obstetrics and gynecology.

[11]  A. Spinillo,et al.  Managing recurrent vulvovaginal candidiasis. Intermittent prevention with itraconazole. , 1997, The Journal of reproductive medicine.

[12]  H. Degreef,et al.  Itraconazole for the treatment of tinea pedis: a dosage of 400 mg/day given for 1 week is similar in efficacy to 100 or 200 mg/day given for 2 to 4 weeks. , 1997, Journal of the American Academy of Dermatology.

[13]  P. Marone,et al.  Prevalence of and risk factors for fungal vaginitis caused by non-albicans species. , 1997, American journal of obstetrics and gynecology.

[14]  G. Piérard,et al.  Antifungal activity of itraconazole and terbinafine in human stratum corneum: a comparative study. , 1995, Journal of the American Academy of Dermatology.

[15]  S. Higgins,et al.  Comparison of clotrimazole, fluconazole and itraconazole in vaginal candidiasis. , 1995, The British journal of clinical practice.

[16]  J. Sobel,et al.  Comparative in vitro activity of antimycotic agents against pathogenic vaginal yeast isolates. , 1994, Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology.

[17]  G. Creatsas,et al.  Chronic or recurrent vaginal candidosis: short-term treatment and prophylaxis with itraconazole. , 1993, Clinical therapeutics.

[18]  J. Sobel Candidal Vulvovaginitis , 1993, Clinical obstetrics and gynecology.

[19]  G. Stein,et al.  Placebo-controlled trial of itraconazole for treatment of acute vaginal candidiasis , 1993, Antimicrobial Agents and Chemotherapy.

[20]  I. Fong,et al.  The value of chronic suppressive therapy with itraconazole versus clotrimazole in women with recurrent vaginal candidiasis. , 1992, Genitourinary medicine.

[21]  J. Tobin,et al.  Treatment of vaginal candidosis: a comparative study of the efficacy and acceptability of itraconazole and clotrimazole. , 1992, Genitourinary medicine.

[22]  J. Ortonne,et al.  Comparative study of ketoconazole 2% foaming gel and betamethasone dipropionate 0.05% lotion in the treatment of seborrhoeic dermatitis in adults. , 1992, Dermatology.

[23]  L. Sobral,et al.  Itraconazole versus placebo in the management of vaginal candidiasis , 1991, International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics.

[24]  M. Plempel,et al.  Modulation of leukotriene metabolism from human polymorphonuclear granulocytes by bifonazole , 1991, Mycoses.

[25]  D. Steinhilber,et al.  Effects of novel antifungal azole derivatives on the 5-lipoxygenase and cyclooxygenase pathway. , 1990, Arzneimittel-Forschung.

[26]  R. Woestenborghs,et al.  The Clinical Pharmacokinetics of Itraconazole: An Overview , 1989, Mycoses.

[27]  I. Bergbrant,et al.  Seborrhoeic dermatitis and Pityrosporum ovale: a cultural and immunological study. , 1989, Acta dermato-venereologica.

[28]  J. Meyer,et al.  Itraconazole in the treatment of acute vaginal candidiasis. , 1988, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

[29]  R. Hay,et al.  First International Symposium on Itraconazole: A Summary , 1987 .

[30]  F. Sanz,et al.  Randomized Comparative Trial of Three Regimens of Itraconazole for Treatment of Vaginal Mycoses , 1987 .

[31]  V. Schuermans,et al.  Itraconazole in the treatment of human mycoses: review of three years of clinical experience. , 1987, Reviews of infectious diseases.

[32]  J. Heykants,et al.  Itraconazole: pharmacologic studies in animals and humans. , 1987, Reviews of infectious diseases.

[33]  J. Faergemann Treatment of Sebopsoriasis with Itraconazole:Behandlung von Sebopsoriasis mit Itraconazole , 1985 .

[34]  J. Faergemann Treatment of sebopsoriasis with itraconazole. , 1985, Mykosen.

[35]  P. Farr,et al.  The response of seborrhoeic dermatitis to ketoconazole , 1984, The British journal of dermatology.

[36]  J. Faergemann Quantitative Culture of Pityrosporon Orbiculare , 1984, International journal of dermatology.

[37]  J. Leyden,et al.  Quantitative microbiology of the scalp in non-dandruff, dandruff, and seborrheic dermatitis. , 1975, The Journal of investigative dermatology.