Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties

[1]  T. Patel,et al.  MicroRNA expression profiling: A molecular tool for defining the phenotype of hepatocellular tumors , 2008, Hepatology.

[2]  S. Thorgeirsson,et al.  Molecular pathogenesis of human hepatocellular carcinoma , 2002, Nature Genetics.

[3]  Akedo Hitoshi,et al.  Participation of rhop21 in serum‐dependent invasion by rat ascites hepatoma cells , 1995, FEBS letters.

[4]  Jen-Leih Wu,et al.  miR-122 targets an anti-apoptotic gene, Bcl-w, in human hepatocellular carcinoma cell lines. , 2008, Biochemical and biophysical research communications.

[5]  W. Gerald,et al.  Endogenous human microRNAs that suppress breast cancer metastasis , 2008, Nature.

[6]  C. Croce,et al.  Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[7]  T. Tuschl,et al.  Identification of Tissue-Specific MicroRNAs from Mouse , 2002, Current Biology.

[8]  Krista A. Zanetti,et al.  Identification of metastasis‐related microRNAs in hepatocellular carcinoma , 2008, Hepatology.

[9]  Nathalie Wong,et al.  MicroRNA-223 is commonly repressed in hepatocellular carcinoma and potentiates expression of Stathmin1. , 2008, Gastroenterology.

[10]  S. Thorgeirsson,et al.  A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells , 2006, Nature Medicine.

[11]  S. Thorgeirsson,et al.  Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype. , 2006, The Journal of clinical investigation.

[12]  C. Sander,et al.  miR-122, a Mammalian Liver-Specific microRNA, is Processed from hcr mRNA and MayDownregulate the High Affinity Cationic Amino Acid Transporter CAT-1 , 2004, RNA biology.

[13]  A. Krasnitz,et al.  DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma. , 2008, Genes & development.

[14]  S. Thorgeirsson,et al.  Functional and genomic implications of global gene expression profiles in cell lines from human hepatocellular cancer , 2002, Hepatology.

[15]  Nicola J. Rinaldi,et al.  Control of Pancreas and Liver Gene Expression by HNF Transcription Factors , 2004, Science.

[16]  S. Thorgeirsson,et al.  Application of comparative functional genomics to identify best-fit mouse models to study human cancer , 2004, Nature Genetics.

[17]  S. Thorgeirsson,et al.  Oncogene‐specific gene expression signatures at preneoplastic stage in mice define distinct mechanisms of hepatocarcinogenesis , 2006, Hepatology.

[18]  S. Thorgeirsson,et al.  Classification and prediction of survival in hepatocellular carcinoma by gene expression profiling , 2004, Hepatology.

[19]  Mark Graham,et al.  miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting. , 2006, Cell metabolism.

[20]  H. El‐Serag,et al.  Hepatocellular carcinoma: recent trends in the United States. , 2004, Gastroenterology.

[21]  Puneet Puri,et al.  Nonalcoholic steatohepatitis is associated with altered hepatic MicroRNA expression , 2008, Hepatology.

[22]  S. Thorgeirsson,et al.  Transforming growth factor‐β gene expression signature in mouse hepatocytes predicts clinical outcome in human cancer , 2008, Hepatology.

[23]  T. Okanoue,et al.  Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues , 2006, Oncogene.

[24]  A. Jemal,et al.  Global Cancer Statistics , 2011 .

[25]  Asaf Levy,et al.  MicroRNA Expression Patterns and Function in Endodermal Differentiation of Human Embryonic Stem Cells , 2008, PloS one.

[26]  M. Czech.  MicroRNAs as therapeutic targets. , 2006, The New England journal of medicine.

[27]  Xiaoqing Tang,et al.  A simple array platform for microRNA analysis and its application in mouse tissues. , 2007, RNA.

[28]  Peter Schirmacher,et al.  MicroRNA gene expression profile of hepatitis C virus–associated hepatocellular carcinoma , 2007, Hepatology.

[29]  J. Ferlay,et al.  Global Cancer Statistics, 2002 , 2005, CA: a cancer journal for clinicians.

[30]  Jinhong Chang,et al.  Liver-Specific MicroRNA miR-122 Enhances the Replication of Hepatitis C Virus in Nonhepatic Cells , 2008, Journal of Virology.

[31]  S. Kauppinen,et al.  LNA-mediated microRNA silencing in non-human primates , 2008, Nature.

[32]  Michael Niepmann,et al.  microRNA-122 stimulates translation of hepatitis C virus RNA , 2008, The EMBO journal.

[33]  V. Ambros.  The functions of animal microRNAs , 2004, Nature.

[34]  F. Slack,et al.  Oncomirs — microRNAs with a role in cancer , 2006, Nature Reviews Cancer.

[35]  H. Horvitz,et al.  MicroRNA expression profiles classify human cancers , 2005, Nature.

[36]  Domenico Coppola,et al.  MicroRNA-155 Is Regulated by the Transforming Growth Factor β/Smad Pathway and Contributes to Epithelial Cell Plasticity by Targeting RhoA , 2008, Molecular and Cellular Biology.

[37]  Laura Pelletier,et al.  MicroRNA profiling in hepatocellular tumors is associated with clinical features and oncogene/tumor suppressor gene mutations , 2008, Hepatology.

[38]  Derek Y. Chiang,et al.  Genomics and signaling pathways in hepatocellular carcinoma. , 2007, Seminars in liver disease.

[39]  K. Ghoshal,et al.  Downregulation of miR‐122 in the rodent and human hepatocellular carcinomas , 2006, Journal of cellular biochemistry.

[40]  V. Moreau,et al.  Rho GTPases in hepatocellular carcinoma. , 2009, Biochimica et biophysica acta.

[41]  Jianren Gu,et al.  Diagnostic and prognostic implications of microRNAs in human hepatocellular carcinoma , 2008, International journal of cancer.

[42]  C. Croce,et al.  Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma. , 2007, Cancer research.

[43]  A. Munnich,et al.  miR-122, a paradigm for the role of microRNAs in the liver. , 2008, Journal of hepatology.

[44]  N. Rajewsky,et al.  Silencing of microRNAs in vivo with ‘antagomirs’ , 2005, Nature.

[45]  S. Thorgeirsson,et al.  Functional genomics of hepatocellular carcinoma , 2006, Hepatology.

[46]  Hsien-Da Huang,et al.  MicroRNA‐122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma , 2009, Hepatology.

[47]  P. Sarnow,et al.  Modulation of Hepatitis C Virus RNA Abundance by a Liver-Specific MicroRNA , 2005, Science.