Electrochemical Enantiomer Recognition Based on sp3-to-sp2 Converted Regenerative Graphene/Diamond Electrode

It is of great significance to distinguish enantiomers due to their different, even completely opposite biological, physiological and pharmacological activities compared to those with different stereochemistry. A sp3-to-sp2 converted highly stable and regenerative graphene/diamond electrode (G/D) was proposed as an enantiomer recognition platform after a simple β-cyclodextrin (β-CD) drop casting process. The proposed enantiomer recognition sensor has been successfully used for d and l-phenylalanine recognition. In addition, the G/D electrode can be simply regenerated by half-minute sonication due to the strong interfacial bonding between graphene and diamond. Therefore, the proposed G/D electrode showed significant potential as a reusable sensing platform for enantiomer recognition.

[1]  H. Lapierre,et al.  Milk protein yield and mammary metabolism are affected by phenylalanine deficiency but not by threonine or tryptophan deficiency. , 2016, Journal of dairy science.

[2]  A. Arora,et al.  Therapeutic implication of L-phenylalanine aggregation mechanism and its modulation by D-phenylalanine in phenylketonuria , 2014, Scientific Reports.

[3]  I. Willner,et al.  Beta-cyclodextrin-modified CdSe/ZnS quantum dots for sensing and chiroselective analysis. , 2009, Nano letters.

[4]  T. Ling,et al.  Molecularly imprinted electrochemical sensor, formed on Ag screen-printed electrodes, for the enantioselective recognition of d and l phenylalanine. , 2018, Biosensors & bioelectronics.

[5]  H. Okamoto,et al.  The Au-C (Gold-Carbon) system , 1984 .

[6]  Li Fu,et al.  Highly stable and regenerative graphene-diamond hybrid electrochemical biosensor for fouling target dopamine detection. , 2018, Biosensors & bioelectronics.

[7]  S. Zaidi.  Facile and efficient electrochemical enantiomer recognition of phenylalanine using β-Cyclodextrin immobilized on reduced graphene oxide. , 2017, Biosensors & bioelectronics.

[8]  Chuan Dong,et al.  β-Cyclodextrin functionalized Mn-doped ZnS quantum dots for the chiral sensing of tryptophan enantiomers , 2015 .

[9]  R. Bhushan,et al.  Development of liquid chromatographic methods for enantioseparation and sensitive detection of β-adrenolytics/β2-agonists in human plasma using a single enantiomer reagent. , 2017, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[10]  Tong Liu,et al.  Structural Identification of 19 Purified Isomers of the OPV Acceptor Material bisPCBM by 13C NMR and UV-Vis Absorption Spectroscopy and High-Performance Liquid Chromatography. , 2018, The journal of physical chemistry. A.

[11]  M. Mas‐Torrent,et al.  Chiral magnetic-nanobiofluids for rapid electrochemical screening of enantiomers at a magneto nanocomposite graphene-paste electrode. , 2018, Biosensors & bioelectronics.

[12]  Xiaoquan Lu,et al.  Electrochemical sensor for discrimination tyrosine enantiomers using graphene quantum dots and β-cyclodextrins composites. , 2017, Talanta: The International Journal of Pure and Applied Analytical Chemistry.

[13]  Pramod K. Kalambate,et al.  Enantioselective analysis of Moxifloxacin hydrochloride enantiomers with graphene-β-Cyclodextrin-nanocomposite modified carbon paste electrode using adsorptive stripping differential pulse Voltammetry , 2017 .

[14]  S. Piletsky,et al.  Recent advances in electrochemical sensors based on chiral and nano-sized imprinted polymers , 2018 .

[15]  Alberto Escarpa,et al.  Enzyme-based microfluidic chip coupled to graphene electrodes for the detection of D-amino acid enantiomer-biomarkers. , 2015, Analytical chemistry.