Bullous eruption: a manifestation of lupus erythematosus.

Bullous lupus erythematosus (BSLE) is a rare subset of systemic lupus erythematosus (SLE), often associated with autoimmunity to type VII collagen. Generally, patients with BSLE meet the criteria for SLE as defined by the American College of Rheumatology. We present a case of a 17-year-old adolescent girl who presented with a vesiculobullous eruption without detectable type VII collagen antibodies and without full criteria for SLE. Differential staining was characteristic for lupus erythematosus (LE), suggesting her eruption is related to LE. We review the spectrum of bullous disease in patients with LE and discuss the pathogenesis and histology of these eruptions, as well as current therapeutic options.

[1]  N. Levine,et al.  Dapsone and sulfapyridine. , 2001, Dermatologic clinics.

[2]  A. Oakley,et al.  Bullous systemic lupus erythematosus , 2000, The Australasian journal of dermatology.

[3]  L. Chan,et al.  Autoimmune blistering skin diseases. , 2000, The American journal of emergency medicine.

[4]  D. Zillikens,et al.  Autoimmune and inherited subepidermal blistering diseases: advances in the clinic and the laboratory. , 2000, Advances in dermatology.

[5]  N. Korman,et al.  New and emerging therapies in the treatment of blistering diseases. , 2000, Dermatologic clinics.

[6]  A. Paller,et al.  Bullous systemic lupus erythematosus with autoantibodies recognizing multiple skin basement membrane components, bullous pemphigoid antigen 1, laminin-5, laminin-6, and type VII collagen. , 1999, Archives of dermatology.

[7]  Makino,et al.  Detection of anti‐type VII collagen antibody in Sjögren's syndrome/lupus erythematosus overlap syndrome with transient bullous systemic lupus erythematosus , 1998, The British journal of dermatology.

[8]  M. Insler,et al.  Mucocutaneous features of autoimmune blistering diseases. , 1997, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[9]  C. Herrero,et al.  Uncommon cutaneous manifestations of lupus erythematosus , 1997, Lupus.

[10]  D. Woodley,et al.  Colchicine for epidermolysis bullosa acquisita. , 1996, Journal of the American Academy of Dermatology.

[11]  J. Callen.  Bullous systemic lupus erythematosus: revised criteria for diagnosis , 1995 .

[12]  Rico Mj.  Treatment of autoimmune blistering diseases. , 1993 .

[13]  R. Briggaman,et al.  Epidermolysis bullosa acquisita and bullous systemic lupus erythematosus. Diseases of autoimmunity to type VII collagen. , 1993, Dermatologic clinics.

[14]  L. Finkel,et al.  Bullous eruption in a woman with lupus erythematosus. Bullous systemic lupus erythematosus (SLE) , 1988, Archives of dermatology.

[15]  C. Camisa,et al.  Vesiculobullous systemic lupus erythematosus , 1983 .

[16]  M. Dahl,et al.  Direct immunofluorescence of bullous systemic lupus erythematosus. , 1973, Archives of dermatology.