A nanoscale communication channel with fluorescence resonance energy transfer (FRET)

In this study, a novel and physically realizable nanoscale communication paradigm is introduced based on a well-known phenomenon, Fluorescence Resonance Energy Transfer (FRET) for the first time in the literature. FRET is a nonradiative energy transfer process between fluorescent molecules based on the dipole-dipole interactions of molecules. Energy is transferred rapidly from a donor to an acceptor molecule in a close proximity such as 0 to 10 nm without radiation of a photon. Low dependency on the environmental factors, controllability of its parameters and relatively wide transfer range make FRET a promising candidate to be used for a high rate nanoscale communication channel. In this paper, the simplest form of the FRET-based molecular communication channel for a single transmitter and a single receiver nanomachine is modeled. Furthermore, using the information theoretical approach, the capacity of the point-to-point communication channel is investigated and the dependency of the capacity on some environmental and intrinsic parameters is analyzed. It is shown that the capacity can be increased by appropriately selecting the donor-acceptor pair, the medium, the intermolecular distance and the orientation of the molecules.

[1]  Gaudenz Danuser,et al.  FRET or no FRET: a quantitative comparison. , 2003, Biophysical journal.

[2]  T. Jovin,et al.  FRET imaging , 2003, Nature Biotechnology.

[3]  Tatsuya Suda,et al.  A molecular communication system using a network of cytoskeletal filaments. , 2006 .

[4]  Mike Heilemann,et al.  Multistep energy transfer in single molecular photonic wires. , 2004, Journal of the American Chemical Society.

[5]  BioTechniques DNA Probes Using Fluorescence Resonance Energy Transfer ( FRET ) : Designs and Applications , 2001 .

[6]  Rainer Pepperkok,et al.  Simultaneous detection of multiple green fluorescent proteins in live cells by fluorescence lifetime imaging microscopy , 1999, Current Biology.

[7]  Ian F. Akyildiz,et al.  Nanonetworks: A new communication paradigm , 2008, Comput. Networks.

[8]  M. Barkley,et al.  Two-step FRET as a structural tool. , 2003, Journal of the American Chemical Society.

[9]  J. Eisinger,et al.  The orientational freedom of molecular probes. The orientation factor in intramolecular energy transfer. , 1979, Biophysical journal.

[10]  Ian F. Akyildiz,et al.  A new nanonetwork architecture using flagellated bacteria and catalytic nanomotors , 2010, IEEE Journal on Selected Areas in Communications.

[11]  Th. Förster Zwischenmolekulare Energiewanderung und Fluoreszenz , 1948 .

[12]  Tatsuya Suda,et al.  An autonomous molecular transport system using DNAs and motor proteins in molecular communication , 2007, 2007 2nd Bio-Inspired Models of Network, Information and Computing Systems.

[13]  L. Stryer Fluorescence energy transfer as a spectroscopic ruler. , 1978, Annual review of biochemistry.

[14]  Amit Gupta,et al.  Spectral imaging microscopy web sites and data , 2006, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[15]  Steven S Vogel,et al.  Measurement of FRET efficiency and ratio of donor to acceptor concentration in living cells. , 2006, Biophysical journal.

[16]  Özgür B. Akan,et al.  Carbon nanotube-based nanoscale ad hoc networks , 2010, IEEE Communications Magazine.

[17]  J. Lakowicz Principles of fluorescence spectroscopy , 1983 .

[18]  Tomasz Heyduk,et al.  Measuring protein conformational changes by FRET/LRET. , 2002, Current opinion in biotechnology.

[19]  R. Heim,et al.  Using GFP in FRET-based applications. , 1999, Trends in cell biology.

[20]  G. Patterson,et al.  Förster distances between green fluorescent protein pairs. , 2000, Analytical biochemistry.

[21]  C. Joo,et al.  Advances in single-molecule fluorescence methods for molecular biology. , 2008, Annual review of biochemistry.

[22]  R. Tsien,et al.  green fluorescent protein , 2020, Catalysis from A to Z.

[23]  T. Suda,et al.  Molecular communication for nanomachines using intercellular calcium signaling , 2005, 5th IEEE Conference on Nanotechnology, 2005..

[24]  Bruce J. MacLennan,et al.  Morphogenesis as a model for nano communication , 2010, Nano Commun. Networks.