The threshold of toxicological concern for prenatal developmental toxicity.

[1]  J P Frawley,et al.  Scientific evidence and common sense as a basis for food-packaging regulations. , 1967, Food and cosmetics toxicology.

[2]  R A Ford,et al.  Estimation of toxic hazard--a decision tree approach. , 1978, Food and cosmetics toxicology.

[3]  H. Kay Environmental Health Criteria , 1980 .

[4]  Charles W. Felix Food Protection Technology , 1987 .

[5]  I C Munro,et al.  Safety assessment procedures for indirect food additives: an overview. Report of a workshop. , 1990, Regulatory toxicology and pharmacology : RTP.

[6]  Joint Fao,et al.  Evaluation of certain food additives and contaminants. Forty-first report of the Joint FAO/WHO Expert Committee on Food Additives. , 1993, World Health Organization technical report series.

[7]  Joint Fao,et al.  Evaluation of certain food additives and contaminants. , 2007, World Health Organization technical report series.

[8]  R A Ford,et al.  Correlation of structural class with no-observed-effect levels: a proposal for establishing a threshold of concern. , 1996, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[9]  E Kennepohl,et al.  A procedure for the safety evaluation of flavouring substances. Joint FAO/WHO Expert Committee on Food Additives. , 1999, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[10]  G Würtzen,et al.  Threshold of toxicological concern for chemical substances present in the diet: a practical tool for assessing the need for toxicity testing. , 2000, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[11]  G Würtzen,et al.  Threshold of toxicological concern for chemical substances present in the diet. Report of a workshop, 5-6 October 1999, Paris, France. , 2001, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[12]  N. Haigh Royal Commission on Environmental Pollution, Chemicals in Products: Safeguarding the Environment and Human Health, 24th Report, Cm 5827 , 2004 .

[13]  Horst Spielmann,et al.  Animal testing and alternative approaches for the human health risk assessment under the proposed new European chemicals regulation , 2004, Archives of Toxicology.

[14]  A G Renwick Toxicology databases and the concept of thresholds of toxicological concern as used by the JECFA for the safety evaluation of flavouring agents. , 2004, Toxicology letters.

[15]  Michael Dourson,et al.  Application of the threshold of toxicological concern concept to pharmaceutical manufacturing operations. , 2005, Regulatory toxicology and pharmacology : RTP.

[16]  A G Renwick,et al.  Structure-based thresholds of toxicological concern--guidance for application to substances present at low levels in the diet. , 2005, Toxicology and applied pharmacology.

[17]  Watze de Wolf,et al.  Mode of action and aquatic exposure thresholds of no concern , 2005, Environmental toxicology and chemistry.

[18]  Karen Blackburn,et al.  Application of the threshold of toxicological concern approach to ingredients in personal and household care products. , 2005, Regulatory toxicology and pharmacology : RTP.

[19]  Lutz Müller,et al.  A rationale for determining, testing, and controlling specific impurities in pharmaceuticals that possess potential for genotoxicity. , 2006, Regulatory toxicology and pharmacology : RTP.

[20]  Helmut Greim,et al.  Application of the threshold of toxicological concern (TTC) to the safety evaluation of cosmetic ingredients. , 2007, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[21]  U. Gundert-Remy,et al.  Exposure-triggered reproductive toxicity testing under the REACH legislation: a proposal to define significant/relevant exposure. , 2008, Toxicology letters.

[22]  Thomas Hartung,et al.  Chemical regulators have overreached , 2009, Nature.

[23]  Richard S. Judson,et al.  Profiling the activity of environmental chemicals in prenatal developmental toxicity studies using the U.S. EPA's ToxRefDB. , 2009, Reproductive toxicology.

[24]  Krista L Dobo,et al.  Overview of Genotoxic Impurities in Pharmaceutical Development , 2009, International journal of toxicology.

[25]  S. Gutsell,et al.  Exposure based waiving: the application of the toxicological threshold of concern (TTC) to inhalation exposure for aerosol ingredients in consumer products. , 2009, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[26]  Vijay K Gombar,et al.  In silico approaches to predicting cancer potency for risk assessment of genotoxic impurities in drug substances. , 2010, Regulatory toxicology and pharmacology : RTP.

[27]  Wolfgang Dekant,et al.  Application of the "threshold of toxicological concern" to derive tolerable concentrations of "non-relevant metabolites" formed from plant protection products in ground and drinking water. , 2010, Regulatory toxicology and pharmacology : RTP.