论文信息 - Specific cellular immune response to pancreas antigen (PA3) in chronic pancreatitis and Sjögren syndrome

Specific cellular immune response to pancreas antigen (PA3) in chronic pancreatitis and Sjögren syndrome

外分泌腺導管上皮に対するモノクローナル抗体を用い膵抗原(PA3)を精製し,慢性膵炎, Sjogren症候群(SjS)などにおける特異的細胞性免疫応答をリンパ球幼若化反応により検討した.その結果,健常人: 0/14 (0%),特発性慢性膵炎: 5/20 (25%),アルコール性慢性膵炎: 3/12 (25%),胆石随伴性慢性膵炎: 0/7 (0%), SjS: 10/15 (67%), PBC: 1/8 (13%), SLE: 2/6 (33%),慢性甲状腺炎: 0/5 (0%)の陽性率であった.以上の成績より本抗原が慢性膵炎, SjSの病因あるいは病態に関与する標的抗原の1つである可能性が考えられた.

[1] S. Sherlock,et al. PRIMARY BILIARY CIRRHOSIS IS A DRY GLAND SYNDROME WITH FEATURES OF CHRONIC GRAFT-VERSUS-HOST DISEASE , 1980, The Lancet.

[2] K. Pálóczi,et al. Immunological investigations in acute and chronic human pancreatitis. , 1980, Digestion.

[3] C. Schütt,et al. Specific lymphocyte sensitization in chronic pancreatitis. , 1975, Digestion.

[4] P. Bacon,et al. Cell-mediated immunity in Sjögren's syndrome. , 1972, Annals of the rheumatic diseases.

[5] R. Metzgar,et al. Studies on organ specificity. XI. Isoantigens of rabbit pancreas. , 1960, Journal of immunology.

[6] N. Rose,et al. Studies on organ specificity X. The serologic specificity of pancreas extracts. , 1960, Journal of immunology.