Failla memorial lecture. The search for critical cellular targets damaged by heat.

L'auteur discute l'action de l'hyperthermie sur les cellules de Mammiferes et des nombreux problemes qui sont lies. Il suggere que les principaux effets cellulaires de l'hyperthermie resultent de la denaturation et de l'agregation des proteines dans la cellule et ce phenomene est responsable de la mort cellulaire de la radiosensibilisation par la chaleur que la chaleur est administree avant l'irradiation

[1]  W. Dewey,et al.  A direct correlation between hyperthermia‐induced membrane blebbing and survival in synchronous G1 CHO cells , 1986, Journal of cellular physiology.

[2]  W. Dewey,et al.  DNA fork displacement rate measurements in heated Chinese hamster ovary cells. , 1989, Biochimica et biophysica acta.

[3]  B. Matthews,et al.  Enhanced protein thermostability from site-directed mutations that decrease the entropy of unfolding. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[4]  W. Dewey,et al.  Molecular studies on the hyperthermic inhibition of DNA synthesis in Chinese hamster ovary cells. , 1982, Radiation research.

[5]  W. Dewey,et al.  Hyperthermic radiosensitization of synchronous Chinese hamster cells: relationship between lethality and chromosomal aberrations. , 1978, Radiation research.

[6]  C. Koch,et al.  Hyperthermia-induced inhibition of respiration and mitochondrial protein denaturation in CHL cells. , 1987, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[7]  G. Hahn,et al.  Ethanol-induced tolerance to heat and to adriamycin , 1978, Nature.

[8]  J. Brandts,et al.  Calorimetric studies of the structural transitions of the human erythrocyte membrane. Studies of the B and C transitions. , 1978, Biochimica et biophysica acta.

[9]  W. Dewey,et al.  Effects of hyperthermia on dividing Chinese hamster ovary cells and on microtubules in vitro. , 1982, Cancer research.

[10]  W. Dewey,et al.  The role of low intracellular or extracellular pH in sensitization to hyperthermia. , 1988, Radiation research.

[11]  W. Dewey,et al.  Two distinct modes of hyperthermic cell death. , 1988, Radiation research.

[12]  W. Dewey,et al.  Effect of hyperthermia on intracellular pH in Chinese hamster ovary cells. , 1987, Radiation research.

[13]  R. Warters,et al.  Apurinic site induction in the DNA of cells heated at hyperthermic temperatures , 1987, Journal of cellular physiology.

[14]  W. Dewey,et al.  DNA polymerase α and β activities during the cell cycle and their role in heat radiosensitization in Chinese hamster ovary cells , 1985 .

[15]  J. Lepock,et al.  Thermal analysis of CHL V79 cells using differential scanning calorimetry: Implications for hyperthermic cell killing and the heat shock response , 1988, Journal of cellular physiology.

[16]  A. Cress,et al.  Rapid loss of stress fibers in Chinese hamster ovary cells after hyperthermia. , 1985, Cancer research.

[17]  Anaesthetics on the mind , 1987, Nature.

[18]  J. Lepock,et al.  Thermotropic lipid and protein transitions in chinese hamster lung cell membranes: relationship to hyperthermic cell killing. , 1983, Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire.

[19]  W. Dewey,et al.  Variation in sensitivity to heat shock during the cell-cycle of Chinese hamster cells in vitro. , 1971, International journal of radiation biology and related studies in physics, chemistry, and medicine.

[20]  W. Dewey,et al.  Effects of heat on the centrosomes of Chinese hamster ovary cells. , 1978, Cancer research.

[21]  G. Hahn,et al.  Investigation of adenylate energy charge, phosphorylation potential, and ATP concentration in cells stressed with starvation and heat , 1985, Journal of cellular physiology.

[22]  W. Dewey,et al.  Cellular responses to combinations of hyperthermia and radiation. , 1977, Radiology.

[23]  G. Li,et al.  Heat-resistant variants of Chinese hamster fibroblasts altered in expression of heat shock protein. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[24]  T. D. Brock.  Life at High Temperatures , 1985, Science.

[25]  G. Hahn,et al.  Rapid increases in inositol trisphosphate and intracellular Ca++ after heat shock. , 1986, Biochemical and biophysical research communications.

[26]  K. Henle,et al.  Cytotoxicity of hyperthermia combined with bleomycin or cis-platinum in cultured RIF cells: modification by thermotolerance and by polyhydroxy compounds. , 1986, Cancer research.

[27]  W. Dewey,et al.  Intrinsic differences in heat and/or X-ray sensitivity of seven mammalian cell lines cultured and treated under identical conditions. , 1979, Cancer research.

[28]  R. Warters,et al.  Excision of X-ray-induced thymine damage in chromatin from heated cells. , 1979, Radiation research.

[29]  J. Lepock,et al.  Role of extracellular calcium in the hyperthermic killing of CHL V79 cells. , 1987, Radiation research.

[30]  H. Kampinga,et al.  Heat-induced alterations in DNA polymerase activity of HeLa cells and of isolated nuclei. Relation to cell survival. , 1985, International journal of radiation biology and related studies in physics, chemistry, and medicine.

[31]  R. Coss,et al.  Effects of hyperthermia on the cytoskeleton and cell survival in G1 and S phase Chinese hamster ovary cells. , 1990, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[32]  M. Yatvin.  The influence of membrane lipid composition and procaine on hyperthermic death of cells. , 1977, International journal of radiation biology and related studies in physics, chemistry, and medicine.

[33]  Henry Eyring,et al.  The kinetic basis of molecular biology , 1954 .

[34]  W. Dewey,et al.  Effect of glycerol and low pH on heat-induced cell killing and loss of cellular DNA polymerase activities in Chinese hamster ovary cells. , 1984, Radiation research.

[35]  P. Whitaker-Dowling,et al.  Stress induces an increased hexose uptake in cultured cells , 1986, Journal of cellular physiology.

[36]  W. Dewey,et al.  Induction of heat shock proteins in Chinese hamster ovary cells and development of thermotolerance by intermediate concentrations of puromycin , 1987, Journal of cellular physiology.

[37]  W. Dewey,et al.  Effects of Hyperthermia (41.5°) on Chinese Hamster Ovary Cells Analyzed in Mitosis , 1979 .

[38]  W. Dewey,et al.  Rapidly reversible enzyme inhibition in a temperature‐sensitive mammalian cell mutant lacks thermotolerance , 1989, Journal of cellular physiology.

[39]  W. Dewey,et al.  Evaluation of a role for intracellular Na+, K+, Ca2+, and Mg2+ in hyperthermic cell killing. , 1986, Radiation research.

[40]  J. M. Ritchie.  An Overview of the Mechanisms of Local Anesthetic Action Past, Present, and Future , 1986 .

[41]  W. Dewey,et al.  Time-temperature analyses of cell killing of synchronous G1 and S phase Chinese hamster cells in vitro. , 1988, Radiation research.

[42]  W. Dewey,et al.  Cell biology of hyperthermia and radiation , 1979 .

[43]  J R Oleson,et al.  Tumor temperature distributions predict hyperthermia effect. , 1989, International journal of radiation oncology, biology, physics.

[44]  W. Dewey,et al.  Heat Sensitization of G1- and S-Phase Cells by Procaine Hydrochloride , 1982 .

[45]  A. Klibanov,et al.  Analysis of processes causing thermal inactivation of enzymes. , 1988, Methods of biochemical analysis.

[46]  W. Dewey,et al.  Effect of hyperthermia on nonhistone proteins isolated with DNA. , 1978, Radiation research.

[47]  R. Warters,et al.  The effects of hyperthermia on DNA replication in HeLa cells. , 1983, Radiation research.

[48]  H H Miller,et al.  Heat-induced lethality and chromosomal damage in synchronized Chinese hamster cells treated with 5-bromodeoxyuridine. , 1971, International journal of radiation biology and related studies in physics, chemistry, and medicine.

[49]  W. Dewey,et al.  Effect of cycloheximide on heat-induced cell killing, radiosensitization, and loss of cellular DNA polymerase activities in Chinese hamster ovary cells. , 1987, Radiation research.

[50]  E. London,et al.  Similarity of the conformation of diphtheria toxin at high temperature to that in the membrane-penetrating low-pH state. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[51]  J. Overgaard.  The current and potential role of hyperthermia in radiotherapy. , 1989, International journal of radiation oncology, biology, physics.

[52]  K. Henle,et al.  Temperature-dependent induction of thermotolerance by ethanol. , 1986, Radiation research.

[53]  W. Dewey,et al.  The role of low intracellular or extracellular pH in sensitization to hyperthermic radiosensitization. , 1988, Radiation research.

[54]  D. D'avignon,et al.  Correlation between the anaesthetic effect of halothane and saturable binding in brain , 1987, Nature.

[55]  W. Dewey,et al.  Ion‐sensitive microelectrode measurements of free intracellular chloride and potassium concentrations in hyperthermia‐treated neuroblastoma cells , 1986, Journal of cellular physiology.

[56]  G. Hahn,et al.  Heat stress stimulates inositol trisphosphate release and phosphorylation of phosphoinositides in CHO and Balb C 3T3 cells , 1987, Journal of cellular physiology.

[57]  W. Dewey,et al.  Mechanism of killing Chinese hamster ovary cells heated in G1: effects on DNA synthesis and blocking in G2. , 1989, Radiation research.

[58]  N. P. Franks,et al.  Molecular mechanisms of general anaesthesia , 1982, Nature.

[59]  G. Li,et al.  Amino acid analogs while inducing heat shock proteins sensitize CHO cells to thermal damage , 1985, Journal of cellular physiology.

[60]  W. Dewey,et al.  Effect of hyperthermia on CHO DNA polymerases alpha and beta. , 2010, Radiation research.

[61]  W. Dewey,et al.  Radiosensitization with 5-bromodeoxyuridine of Chinese hamster cells x-irradiated during different phases of the cell cycle. , 1971, Radiation research.