Reply to Galen, “Screening Cerebrospinal Fluid Prior to Herpes Simplex Virus PCR Testing Might Miss Cases of Herpes Simplex Encephalitis”

We appreciate the correspondence from Dr. Galen ([1][1]) about our study and value his interest in expanding the discussion of the cost-effectiveness of screening herpes simplex virus (HSV) in cerebrospinal fluid (CSF) ([2][2]). He raises a number of important assertions upon which we feel compelled