Markers of renal function tests

Background: The markers of renal function test assess the normal functioning of kidneys. These markers may be radioactive and non radioactive. They indicate the glomerular filtration rate, concentrating and diluting capacity of kidneys (tubular function). If there is an increase or decrease in the valves of these markers it indicates dysfunction of kidney. Aim: The aim of this review is to compare and analyze the present and newer markers of renal function tests which help in diagnosis of clinical disorders. Material & Methods: An extensive literature survey was done aiming to compare and compile renal function tests makers required in diagnosis of diseases. Results: Creatinine, urea, uric acid and electrolytes are makers for routine analysis whereas several studies have confirmed and consolidated the usefulness of markers such as cystatin C and β-Trace Protein. Conclusion: We conclude that further investigation is necessary to define these biomarkers in terms of usefulness in assessing renal function.

[1]  Y. Zuo,et al.  Simultaneous Determination of Creatinine and Uric Acid in Human Urine by High-Performance Liquid Chromatography , 2008, Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.

[2]  E. Cholongitas,et al.  Review article: renal function assessment in cirrhosis – difficulties and alternative measurements , 2007, Alimentary pharmacology & therapeutics.

[3]  M. Landray,et al.  A Practical Method of Measuring Glomerular Filtration Rate by Iohexol Clearance Using Dried Capillary Blood Spots , 2007, Nephron Clinical Practice.

[4]  S. Del Prato,et al.  Cystatin C and estimates of renal function: searching for a better measure of kidney function in diabetic patients. , 2007, Clinical chemistry.

[5]  R. Vasan,et al.  Biomarkers of Cardiovascular Disease: Molecular Basis and Practical Considerations , 2006, Circulation.

[6]  R. Zietse,et al.  Renal extraction of cystatin C vs 125I-iothalamate in hypertensive patients. , 2006, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[7]  A. Bagga,et al.  Approach to renal tubular disorders , 2005, Indian journal of pediatrics.

[8]  Edward R. Ashwood,et al.  Tietz Textbook of Clinical Chemistry and Molecular Diagnostics , 2005 .

[9]  J. Wetzels,et al.  Serum creatinine is a poor marker of GFR in nephrotic syndrome. , 2005, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[10]  M. Kilby,et al.  Optimal bedside urinalysis for the detection of proteinuria in hypertensive pregnancy: a study of diagnostic accuracy , 2005, BJOG : an international journal of obstetrics and gynaecology.

[11]  A. Killeen,et al.  Creatinine measurement: state of the art in accuracy and interlaboratory harmonization. , 2005, Archives of pathology & laboratory medicine.

[12]  J. Waugh,et al.  PROTEINURIA IN PREGNANCY – JUST WHAT IS SIGNIFICANT? , 2005 .

[13]  B. Psaty,et al.  Cystatin-C and mortality in elderly persons with heart failure. , 2005, Journal of the American College of Cardiology.

[14]  M. J. Murphy,et al.  An immunodiagnostic method for the detection of Shiga-like toxigenic Escherichia coli in faeces , 2003, Journal of clinical pathology.

[15]  J. Sands.  Urine-concentrating ability in the aging kidney. , 2003, Science of aging knowledge environment : SAGE KE.

[16]  V. Dharnidharka,et al.  Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta-analysis. , 2002, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[17]  H. Clark,et al.  β-Trace Protein, Cystatin C, β2-Microglobulin, and Creatinine Compared for Detecting Impaired Glomerular Filtration Rates in Children , 2002 .

[18]  A. Gerbes,et al.  Evaluation of serum cystatin C concentration as a marker of renal function in patients with cirrhosis of the liver , 2002, Gut.

[19]  K. Jung,et al.  β-Trace Protein Is Not Better than Cystatin C as an Indicator of Reduced Glomerular Filtration Rate , 2001 .

[20]  T. Sauerbruch,et al.  Low-molecular weight proteins as markers for glomerular filtration rate. , 2001, Clinical chemistry.

[21]  P. Agre,et al.  Defective urinary concentrating ability due to a complete deficiency of aquaporin-1. , 2001, The New England journal of medicine.

[22]  G. Hughes,et al.  Chromium-51 ethylenediamine tetraacetic acid glomerular filtration rate: a better predictor than glomerular filtration rate calculated by the Cockcroft-Gault formula for renal involvement in systemic lupus erythematosus patients. , 2001, Rheumatology.

[23]  J. Corbett.  Laboratory Tests and Diagnostic Procedures with Nursing Diagnoses , 2000 .

[24]  K. Jung,et al.  Beta-trace protein in serum: a new marker of glomerular filtration rate in the creatinine-blind range. , 1999, Clinical chemistry.

[25]  E. Erlandsen,et al.  Serum Cystatin C as an Endogenous Marker of the Renal Function – a Review , 1999, Clinical chemistry and laboratory medicine.

[26]  S. Groth,et al.  Chromium-51-EDTA clearance in adults with a single-plasma sample. , 1998, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[27]  Kathleen Deska Pagana,et al.  Mosby's Manual of Diagnostic and Laboratory Tests , 1998 .

[28]  M. Nimtz,et al.  Molecular characterization of beta-trace protein in human serum and urine: a potential diagnostic marker for renal diseases. , 1997, Glycobiology.

[29]  R. Browne,et al.  125Iodine-iothalamate clearance in children. A simple method to measure glomerular filtration , 1996, Pediatric Nephrology.

[30]  J. Y. Chen,et al.  Urinary beta 2-microglobulin and N-acetyl-beta-D-glucosaminidase (NAG) as early markers of renal tubular dysfunction in sick neonates. , 1991, Journal of the Formosan Medical Association = Taiwan yi zhi.

[31]  H. Tsukahara,et al.  Assessment of tubular function in neonates using urinary β2-microglobulin , 1990, Pediatric Nephrology.

[32]  K. Ohshima.  [KIDNEY FUNCTION TESTS]. , 1964, Nihon Ishikai zasshi. Journal of the Japan Medical Association.

[33]  M. Scott,et al.  Physiology and Disorders of Water, Electrolyte, and Acid-Base Metabolism , 2012 .

[34]  W. K. Bolton,et al.  CORE CURRICULUM IN NEPHROLOGY Renal Function Testing , 2006 .

[35]  P. Shipkova,et al.  Biochemical methods for the assessment of the selectivity of proteinuria , 2005, International Urology and Nephrology.

[36]  S. Sharma,et al.  Evaluation of Random Urine Sample Protein-Cretinine Ratio as an Index of Quantitative Proteinuria , 2004 .

[37]  G. Jerums,et al.  Treatment of Microalbuminuria in Patients with Type 2 Diabetes Mellitus , 2002, Treatments in endocrinology.

[38]  B. Kasiske,et al.  Determination of residual renal function with iohexol clearance in hemodialysis patients. , 1996, Kidney international.

[39]  H. Tsukahara,et al.  Assessment of tubular function in neonates using urinary beta 2-microglobulin. , 1990, Pediatric nephrology.

[40]  J. Kotzerke,et al.  Serum Creatinine Values in Elite Athletes Competing in 8 Different Sports : Comparison with Sedentary People , 2022 .