Endotoxemia and sepsis mortality reduction by non-anticoagulant–activated protein C
暂无分享,去创建一个
Nigel Mackman | Edward J. Kerschen | John H. Griffin | Francis J. Castellino | José A Fernández | J. Griffin | N. Mackman | F. Castellino | Xia V. Yang | E. Kerschen | H. Weiler | B. Cooley | José A. Fernández | Laurent O. Mosnier | Hartmut Weiler | Brian C. Cooley | R. Sood | José A. Fernandez | Rashmi Sood | L. Mosnier | Jose A. Fernández
[1] M. Gaub,et al. Influence of drotrecogin alpha (activated) infusion on the variation of Bax/Bcl‐2 and Bax/Bcl‐xl ratios in circulating mononuclear cells: A cohort study in septic shock patients , 2007, Critical care medicine.
[2] C. Esmon,et al. Effects of membrane and soluble EPCR on the hemostatic balance and endotoxemia in mice. , 2007, Blood.
[3] P. A. von dem Borne,et al. Plasma TAFI Levels Influence the Clot Lysis Time in Healthy Individuals in the Presence of an Intact Intrinsic Pathway of Coagulation , 1998, Thrombosis and Haemostasis.
[4] S. Opal,et al. High-Dose Antithrombin III in Severe Sepsis: A Randomized Controlled Trial , 2001 .
[5] José A Fernández,et al. Activated Protein C Prevents Neuronal Apoptosis via Protease Activated Receptors 1 and 3 , 2004, Neuron.
[6] L. Gelbert,et al. Gene Expression Profile of Antithrombotic Protein C Defines New Mechanisms Modulating Inflammation and Apoptosis* , 2001, The Journal of Biological Chemistry.
[7] Robert V Farese,et al. Role of the thrombin receptor in development and evidence for a second receptor , 1996, Nature.
[8] E. Rosen,et al. Mice with a Severe Deficiency of the Endothelial Protein C Receptor Gene Develop, Survive, and Reproduce Normally, and Do not Present with Enhanced Arterial Thrombosis after Challenge , 2002, Thrombosis and Haemostasis.
[9] W. Ruf. Is APC activation of endothelial cell PAR1 important in severe sepsis?: Yes , 2005, Journal of thrombosis and haemostasis : JTH.
[10] F. Castellino,et al. A cardioprotective role for the endothelial protein C receptor in lipopolysaccharide-induced endotoxemia in the mouse. , 2005, Blood.
[11] C. Feistritzer,et al. Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation. , 2005, Blood.
[12] J. Garcia,et al. Activated Protein C Mediates Novel Lung Endothelial Barrier Enhancement , 2005, Journal of Biological Chemistry.
[13] C. Esmon,et al. Inflammation and the activated protein C anticoagulant pathway. , 2006, Seminars in thrombosis and hemostasis.
[14] P. Newman,et al. Endothelial cell PECAM-1 confers protection against endotoxic shock. , 2005, American journal of physiology. Heart and circulatory physiology.
[15] C. Esmon,et al. PAR1 Cleavage and Signaling in Response to Activated Protein C and Thrombin* , 2005, Journal of Biological Chemistry.
[16] R. Hotchkiss,et al. Apoptosis and caspases regulate death and inflammation in sepsis , 2006, Nature Reviews Immunology.
[17] S. Jana,et al. Comparison of apoptosis and mortality measurements in peripheral blood mononuclear cells (PBMCs) using multiple methods , 2005, Cell proliferation.
[18] S. Opal,et al. Caring for the critically ill patient. High-dose antithrombin III in severe sepsis: a randomized controlled trial. , 2001, JAMA.
[19] D. S. Sivia,et al. Data Analysis , 1996, Encyclopedia of Evolutionary Psychological Science.
[20] P. A. Peterson,et al. Biological Consequences of Thrombin Receptor Deficiency in Mice , 1996, Thrombosis and Haemostasis.
[21] J. Griffin,et al. Nonenzymatic anticoagulant activity of the mutant serine protease Ser360Ala‐activated protein C mediated by factor Va , 1997, Protein science : a publication of the Protein Society.
[22] J. Griffin,et al. The cytoprotective protein C pathway. , 2007, Blood.
[23] J. Siewert,et al. Essential Role of Gamma Interferon in Survival of Colon Ascendens Stent Peritonitis, a Novel Murine Model of Abdominal Sepsis , 1998, Infection and Immunity.
[24] Mark D. Williams,et al. ENHANCE: Results of a global open-label trial of drotrecogin alfa (activated) in children with severe sepsis* , 2006, Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.
[25] K. Pfeffer,et al. CECAL LIGATION AND PUNCTURE VERSUS COLON ASCENDENS STENT PERITONITIS: TWO DISTINCT ANIMAL MODELS FOR POLYMICROBIAL SEPSIS , 2004, Shock.
[26] M. Loeb,et al. Patients with severe sepsis vary markedly in their ability to generate activated protein C. , 2004, Blood.
[27] S. Lord,et al. Cause-effect relation between hyperfibrinogenemia and vascular disease. , 2004, Blood.
[28] W. Ruf,et al. Activation of Endothelial Cell Protease Activated Receptor 1 by the Protein C Pathway , 2002, Science.
[29] J. Griffin,et al. Activated protein C variants with normal cytoprotective but reduced anticoagulant activity. , 2004, Blood.
[30] J Ean,et al. Efficacy and safety of recombinant human activated protein C for severe sepsis. , 2001, The New England journal of medicine.
[31] C. Pothoulakis,et al. Role of substance P and the neurokinin 1 receptor in acute pancreatitis and pancreatitis-associated lung injury. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[32] B. Dahlbäck,et al. Regulation of Blood Coagulation by the Protein C Anticoagulant Pathway: Novel Insights Into Structure–Function Relationships and Molecular Recognition , 2005, Arteriosclerosis, thrombosis, and vascular biology.
[33] G. Bernard,et al. Safety and dose relationship of recombinant human activated protein C for coagulopathy in severe sepsis , 2001, Critical care medicine.
[34] C. Spek,et al. Signal transduction induced by activated protein C: no role in protection against sepsis? , 2006, Trends in molecular medicine.
[35] C. Sprung,et al. Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: a randomized controlled trial. , 2003, JAMA.
[36] C. Esmon. Is APC activation of endothelial cell PAR1 important in severe sepsis?: No , 2005, Journal of thrombosis and haemostasis : JTH.
[37] J. Griffin,et al. Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease-activated receptor-1 and endothelial cell protein C receptor. , 2003, The Biochemical journal.