Clinical applicability of functional MRI

Functional MRI (fMRI) has become the most widely used modality for examining human brain function in basic and clinical neuroscience. As compared to the application of fMRI in basic neuroscience research, clinical fMRI presents unique challenges. A growing body of literature supports the feasibility of clinical fMRI, with the best‐studied applications being localization of motor cortex and lateralization of language. While it may be tempting to assume that fMRI will supercede prior approaches, it may turn out that fMRI will be used to complement more difficult or invasive methods rather than replace them entirely. This article focuses on fMRI studies in patients and patient populations. Specific considerations for such applications include pathophysiological effects on functional physiology, brain–behavior correlations in the presence of cognitive or sensorimotor deficits, and test‐retest reliability for longitudinal studies. J. Magn. Reson. Imaging 2006. © 2006 Wiley‐Liss, Inc.

[1]  R. S. Hinks,et al.  Time course EPI of human brain function during task activation , 1992, Magnetic resonance in medicine.

[2]  J. Detre,et al.  Localization of subclinical ictal activity by functional magnetic resonance imaging: Correlation with invasive monitoring , 1995, Annals of neurology.

[3]  Ulrich Dirnagl,et al.  Nitric oxide synthase inhibition does not affect somatosensory evoked potentials in the rat , 1996, Neuroscience Letters.

[4]  J. E Adcock,et al.  Quantitative fMRI assessment of the differences in lateralization of language-related brain activation in patients with temporal lobe epilepsy , 2003, NeuroImage.

[5]  Friedrich G. Woermann,et al.  Memory fMRI lateralizes temporal lobe epilepsy , 2001, Neurology.

[6]  J. Donoghue,et al.  Gaze Direction Modulates Finger Movement Activation Patterns in Human Cerebral Cortex , 1999, The Journal of Neuroscience.

[7]  C. Leveque,et al.  Functional MR imaging in assessment of language dominance in epileptic patients , 2003, NeuroImage.

[8]  Judy Illes,et al.  Memory Lateralization in Medial Temporal Lobe Epilepsy Assessed by Functional MRI , 2002, Epilepsia.

[9]  Yue Cao,et al.  Pilot study of functional MRI to assess cerebral activation of motor function after poststroke hemiparesis. , 1998, Stroke.

[10]  S. Dager,et al.  Brain imaging and the effects of caffeine and nicotine , 2000, Annals of medicine.

[11]  J. Detre,et al.  Functional MRI predicts post-surgical memory following temporal lobectomy. , 2004, Brain : a journal of neurology.

[12]  Ravi S. Menon,et al.  Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[13]  Christopher Nimsky,et al.  Correlation of Sensorimotor Activation with Functional Magnetic Resonance Imaging and Magnetoencephalography in Presurgical Functional Imaging: A Spatial Analysis , 2001, NeuroImage.

[14]  K. Slifer,et al.  Operant-contingency-based preparation of children for functional magnetic resonance imaging. , 2002, Journal of applied behavior analysis.

[15]  J. Detre,et al.  Arterial spin labeling perfusion fMRI with very low task frequency , 2003, Magnetic resonance in medicine.

[16]  D. Gitelman,et al.  On the Use of Caffeine as a Contrast Booster for BOLD fMRI Studies , 2002, NeuroImage.

[17]  Craig E. L. Stark,et al.  When zero is not zero: The problem of ambiguous baseline conditions in fMRI , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[18]  M. D’Esposito,et al.  Functional MRI lateralization of memory in temporal lobe epilepsy , 1998, Neurology.

[19]  M. A. Jacobs,et al.  Perfusion-weighted MRI as a marker of response to treatment in acute and subacute stroke , 2004, Neuroradiology.

[20]  W. Powers,et al.  Effect of stepped hypoglycemia on regional cerebral blood flow response to physiological brain activation. , 1996, The American journal of physiology.

[21]  Afraim Salek-Haddadi,et al.  Event-Related fMRI with Simultaneous and Continuous EEG: Description of the Method and Initial Case Report , 2001, NeuroImage.

[22]  P M Rossini,et al.  Does cerebrovascular disease affect the coupling between neuronal activity and local haemodynamics? , 2004, Brain : a journal of neurology.

[23]  Daniel Y. Kimberg,et al.  Experimental design for functional MRI of scene memory encoding , 2005, Epilepsy & Behavior.

[24]  Jack L. Lancaster,et al.  CBF changes during brain activation: fMRI vs. PET , 2004, NeuroImage.

[25]  R. Kauppinen,et al.  Assessment of brain tissue viability in acute ischemic stroke by BOLD MRI , 2001, NMR in biomedicine.

[26]  Jeff Duyn,et al.  H215O PET validation of steady‐state arterial spin tagging cerebral blood flow measurements in humans , 2000, Magnetic resonance in medicine.

[27]  Gregory G. Brown,et al.  Reproducibility of functional MR imaging: preliminary results of prospective multi-institutional study performed by Biomedical Informatics Research Network. , 2005, Radiology.

[28]  Riitta Salmelin,et al.  Comparison of BOLD fMRI and MEG characteristics to vibrotactile stimulation , 2003, NeuroImage.

[29]  Robert Turner,et al.  A Method for Removing Imaging Artifact from Continuous EEG Recorded during Functional MRI , 2000, NeuroImage.

[30]  C. Sherrington,et al.  On the Regulation of the Blood‐supply of the Brain , 1890, The Journal of physiology.

[31]  David C. Alsop,et al.  Functional MRI and the Wada test provide complementary information for predicting post-operative seizure control , 1999, Seizure.

[32]  K J Werhahn,et al.  Electroencephalography during functional echo‐planar imaging: Detection of epileptic spikes using post‐processing methods , 2000, Magnetic resonance in medicine.

[33]  J. Detre,et al.  Amplitude-modulated continuous arterial spin-labeling 3.0-T perfusion MR imaging with a single coil: feasibility study. , 2005, Radiology.

[34]  John S Duncan,et al.  Preserved verbal memory function in left medial temporal pathology involves reorganisation of function to right medial temporal lobe , 2003, NeuroImage.

[35]  M. Schnall,et al.  Comparison of quantitative perfusion imaging using arterial spin labeling at 1.5 and 4.0 Tesla , 2002, Magnetic resonance in medicine.

[36]  P M Matthews,et al.  Altered Hemodynamic Responses in Patients After Subcortical Stroke Measured by Functional MRI , 2002, Stroke.

[37]  L. Cohen,et al.  Influence of interhemispheric interactions on motor function in chronic stroke , 2004, Annals of neurology.

[38]  M. Hommel,et al.  Vicarious function within the human primary motor cortex? A longitudinal fMRI stroke study. , 2005, Brain : a journal of neurology.

[39]  Andreas A. Ioannides,et al.  Consistent and precise localization of brain activity in human primary visual cortex by MEG and fMRI , 2003, NeuroImage.

[40]  A. Hillis,et al.  MR perfusion imaging reveals regions of hypoperfusion associated with aphasia and neglect , 2000, Neurology.

[41]  W T Blume,et al.  A randomized, controlled trial of surgery for temporal-lobe epilepsy. , 2001, The New England journal of medicine.

[42]  R. Turner,et al.  Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[43]  A Villringer,et al.  Characterization of CBF response to somatosensory stimulation: model and influence of anesthetics. , 1993, The American journal of physiology.

[44]  John S Duncan,et al.  Pre-operative verbal memory fMRI predicts post-operative memory decline after left temporal lobe resection. , 2004, Brain : a journal of neurology.

[45]  V. Schmithorst,et al.  High-resolution functional MRI at 3T in healthy and epilepsy subjects: hippocampal activation with picture encoding task , 2004, Epilepsy & Behavior.

[46]  J. Fell,et al.  Intrasubject reproducibility of presurgical language lateralization and mapping using fMRI , 2003, Neurology.

[47]  Isabelle Berry,et al.  Cortical Areas Involved in Virtual Movement of Phantom Limbs: Comparison with Normal Subjects , 2003, Neurosurgery.

[48]  Pll Siinksen,et al.  Control , 1999 .

[49]  P. Kennedy,et al.  Restoration of neural output from a paralyzed patient by a direct brain connection , 1998, Neuroreport.

[50]  F. Chollet,et al.  Fluoxetine modulates motor performance and cerebral activation of patients recovering from stroke , 2001, Annals of neurology.

[51]  K R Thulborn,et al.  Magnetic resonance imaging of children without sedation: preparation with simulation. , 1997, Journal of the American Academy of Child and Adolescent Psychiatry.

[52]  F Barkhof,et al.  fMRI of visual encoding: Reproducibility of activation , 1999, Human brain mapping.

[53]  R. Cox,et al.  Functional MR activation correlated with intraoperative cortical mapping. , 1997, AJNR. American journal of neuroradiology.

[54]  J. Haxby,et al.  Cholinergic enhancement and increased selectivity of perceptual processing during working memory. , 2000, Science.

[55]  M. D’Esposito,et al.  Empirical analyses of BOLD fMRI statistics. I. Spatially unsmoothed data collected under null-hypothesis conditions. , 1997, NeuroImage.

[56]  M. D’Esposito,et al.  Empirical Analyses of BOLD fMRI Statistics , 1997, NeuroImage.

[57]  François Chollet,et al.  Correlation between cerebral reorganization and motor recovery after subcortical infarcts , 2003, NeuroImage.

[58]  R. Buxton,et al.  Quantitative imaging of perfusion using a single subtraction (QUIPSS and QUIPSS II) , 1998 .

[59]  M. Hallett,et al.  Contribution of the ipsilateral motor cortex to recovery after chronic stroke , 2003, Annals of neurology.

[60]  F. Woermann,et al.  Language lateralization by Wada test and fMRI in 100 patients with epilepsy , 2003, Neurology.

[61]  Jacquie Kurland,et al.  Transcranial Magnetic Stimulation as a Complementary Treatment for Aphasia , 2004, Seminars in speech and language.

[62]  G. Aguirre,et al.  Experimental Design and the Relative Sensitivity of BOLD and Perfusion fMRI , 2002, NeuroImage.

[63]  M. Raichle,et al.  Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[64]  Seong-Gi Kim.  Quantification of relative cerebral blood flow change by flow‐sensitive alternating inversion recovery (FAIR) technique: Application to functional mapping , 1995, Magnetic resonance in medicine.

[65]  R. Nudo,et al.  Stimulation‐induced [14C]2‐deoxyglucose labeling of synaptic activity in the central auditory system , 1986, The Journal of comparative neurology.

[66]  E. Seto,et al.  Quantifying Head Motion Associated with Motor Tasks Used in fMRI , 2001, NeuroImage.

[67]  M. Lauritzen.  Reading vascular changes in brain imaging: is dendritic calcium the key? , 2005, Nature Reviews Neuroscience.

[68]  G L Shulman,et al.  Blood flow and oxygen delivery to human brain during functional activity: Theoretical modeling and experimental data , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[69]  V. Cruz,et al.  Cortical remapping in amputees and dysmelic patients: a functional MRI study. , 2003, NeuroRehabilitation.

[70]  R. T. Constable,et al.  Investigation of the Human Hippocampal Formation Using a Randomized Event-Related Paradigm and Z-Shimmed Functional MRI , 2000, NeuroImage.

[71]  A E Hillis,et al.  Restoring blood pressure reperfused Wernicke’s area and improved language , 2001, Neurology.

[72]  Paul J. Laurienti,et al.  Dietary Caffeine Consumption Modulates fMRI Measures , 2002, NeuroImage.

[73]  N. F. Ramsey,et al.  Reproducibility of fMRI-Determined Language Lateralization in Individual Subjects , 2002, Brain and Language.

[74]  B. Rosen,et al.  A functional MRI study of subjects recovered from hemiparetic stroke. , 1997, Stroke.

[75]  G. J. M. Rutten,et al.  fMRI-Determined Language Lateralization in Patients with Unilateral or Mixed Language Dominance According to the Wada Test , 2002, NeuroImage.

[76]  Donald S. Williams,et al.  Perfusion imaging , 1992, Magnetic resonance in medicine.