Bone resorption by isolated osteoclasts in living versus devitalized bone: Differences in mode and extent and the effects of human recombinant tissue inhibitor of metalloproteinases

The incubation of isolated osteoclasts with devitalized bone has become a widely used method for the recent study of bone resorption. Although the studies employing this method have definitively demonstrated that isolated osteoclasts have an avid capacity to resorb devitalized bone, the resorption in this model appears to be different from that of living bone as observed in vivo and in organ culture studies.

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