Gastro Retentive Drug Delivery Systems-a Novel Approaches of Controlled Drug Delivery Systems

Surfactant-modified materials have been used as potential adsorbent for pollutants removal in environmental applications. Surface stability of the adsorbent was a crucial factor because it not only impact to charge resistance of the adsorbed area but also effect to the loss of adsorbed substance. Recently, polymerization of surfactant admicelle was demonstrated the reduction of surfactant desorption. In this work, the alteration of solution pH and concentration of another polymerizable surfactant type (NOIGEN RN-30) were investigated to evaluate the influence parameter of polymerized and non-polymerized surface stability. Results showed that nonpolymerized surface charges were reversed to the opposite one at pH of 1-2 whereas polymerized surface charges were not changed for every experimental pH. Polymerized surface also showed less surfactant washed out and act as a desirable adsorbent to the modified-material.

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