Bifidobacterium adolescentis Is Effective in Relieving Type 2 Diabetes and May Be Related to Its Dominant Core Genome and Gut Microbiota Modulation Capacity

The prevalence of diabetes mellitus is increasing globally. Probiotics have been shown to be an effective intervention for diabetes. This study focused on the relieving effects and possible mechanisms of 16 strains of two dominant Bifidobacterium species (B. bifidum and B. adolescentis, which exist in the human gut at different life stages) on type 2 diabetes (T2D). The results indicated that more B. adolescentis strains appeared to be superior in alleviating T2D symptoms than B. bifidum strains. This effect was closely related to the ability of B. adolescentis to restore the homeostasis of the gut microbiota, increase the abundance of short-chain fatty acid-producing flora, and alleviate inflammation in mice with T2D. In addition, compared with B. bifidum, B. adolescentis had a higher number of core genes, and these genes were more evolutionarily stable, including unique environmental tolerance, carbon and nitrogen utilization genes, and a blood sugar regulation gene, glgP. This may be one of the reasons why B. adolescentis is more likely to colonize in the adult gut and show a superior ability to relieve T2D. This study provides insights into future studies aimed at investigating probiotics for the treatment of metabolic diseases.

[1]  Wei Chen,et al.  Lactic acid bacteria reduce diabetes symptoms in mice by alleviating gut microbiota dysbiosis and inflammation in different manners. , 2020, Food & function.

[2]  V. Chow,et al.  Production of Neutrophil Extracellular Traps Contributes to the Pathogenesis of Francisella tularemia , 2020, Frontiers in Immunology.

[3]  Bailiang Li,et al.  Screening for Potential Novel Probiotics With Dipeptidyl Peptidase IV-Inhibiting Activity for Type 2 Diabetes Attenuation in vitro and in vivo , 2020, Frontiers in Microbiology.

[4]  J. Sung,et al.  Roseburia Spp. Abundance Associates with Alcohol Consumption in Humans and Its Administration Ameliorates Alcoholic Fatty Liver in Mice. , 2019, Cell host & microbe.

[5]  J. Shaw,et al.  Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9th edition. , 2019, Diabetes research and clinical practice.

[6]  Zi-feng Yang,et al.  Ergosterol peroxide suppresses influenza A virus-induced pro-inflammatory response and apoptosis by blocking RIG-I signaling. , 2019, European journal of pharmacology.

[7]  W. Ratajczak,et al.  Immunomodulatory potential of gut microbiome-derived short-chain fatty acids (SCFAs). , 2019, Acta biochimica Polonica.

[8]  N. Datukishvili,et al.  TNF-α Downregulation Modifies Insulin Receptor Substrate 1 (IRS-1) in Metabolic Signaling of Diabetic Insulin-Resistant Hepatocytes , 2019, Mediators of inflammation.

[9]  Xuegang Luo,et al.  Hypoglycemic effect of Hypericum attenuatum Choisy extracts on type 2 diabetes by regulating glucolipid metabolism and modulating gut microbiota , 2019, Journal of Functional Foods.

[10]  J. González‐Gallego,et al.  Beneficial effects of exercise on gut microbiota functionality and barrier integrity, and gut-liver crosstalk in an in vivo model of early obesity and non-alcoholic fatty liver disease , 2019, Disease Models & Mechanisms.

[11]  L. Fan,et al.  Polysaccharide from Plantago asiatica L. attenuates hyperglycemia, hyperlipidemia and affects colon microbiota in type 2 diabetic rats , 2017, Food Hydrocolloids.

[12]  Mingyi Chen,et al.  Huang-Lian-Jie-Du-Decoction Ameliorates Hyperglycemia and Insulin Resistant in Association With Gut Microbiota Modulation , 2018, Front. Microbiol..

[13]  M. Racchi,et al.  Steroid hormones, endocrine disrupting compounds and immunotoxicology , 2018, Current Opinion in Toxicology.

[14]  Z. Xiu,et al.  Anti-diabetic effect of baicalein is associated with the modulation of gut microbiota in streptozotocin and high-fat-diet induced diabetic rats , 2018, Journal of Functional Foods.

[15]  H. Xie,et al.  Effects of shenling baizhu powder herbal formula on intestinal microbiota in high-fat diet-induced NAFLD rats. , 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[16]  F. Bishehsari,et al.  Dietary Fiber Treatment Corrects the Composition of Gut Microbiota, Promotes SCFA Production, and Suppresses Colon Carcinogenesis , 2018, Genes.

[17]  F. Alaei-Shahmiri,et al.  Comparison of gut microbiota in adult patients with type 2 diabetes and healthy individuals. , 2017, Microbial pathogenesis.

[18]  A. Hosoyama,et al.  Comparative analysis of the intestinal flora in type 2 diabetes and nondiabetic mice , 2017, Experimental animals.

[19]  H. Zhang,et al.  Effects of Lactobacillus casei CCFM419 on insulin resistance and gut microbiota in type 2 diabetic mice. , 2017, Beneficial microbes.

[20]  R. Sharma,et al.  Lactobacillus rhamnosus NCDC17 ameliorates type-2 diabetes by improving gut function, oxidative stress and inflammation in high-fat-diet fed and streptozotocintreated rats. , 2017, Beneficial microbes.

[21]  M. Hattori,et al.  A proliferative probiotic Bifidobacterium strain in the gut ameliorates progression of metabolic disorders via microbiota modulation and acetate elevation , 2017, Scientific Reports.

[22]  Wai-Jiao Tang,et al.  Imbalance of intestinal flora: A new target for nonalcoholic fatty liver disease treatment , 2017 .

[23]  D. Wishart,et al.  Improved Glucose Homeostasis in Obese Mice Treated With Resveratrol Is Associated With Alterations in the Gut Microbiome , 2016, Diabetes.

[24]  Yun M. Zhao,et al.  KPNβ1 promotes palmitate-induced insulin resistance via NF-κB signaling in hepatocytes , 2015, Journal of Physiology and Biochemistry.

[25]  F. Servant,et al.  The Gut Microbiota Regulates Intestinal CD4 T Cells Expressing RORγt and Controls Metabolic Disease. , 2015, Cell metabolism.

[26]  Wei Chen,et al.  Metagenomic insights into the effects of fructo-oligosaccharides (FOS) on the composition of fecal microbiota in mice. , 2015, Journal of agricultural and food chemistry.

[27]  E. Aguilar,et al.  Butyrate impairs atherogenesis by reducing plaque inflammation and vulnerability and decreasing NFκB activation. , 2014, Nutrition, metabolism, and cardiovascular diseases : NMCD.

[28]  Jimmy D Bell,et al.  The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism , 2014, Nature Communications.

[29]  J. Shaw,et al.  Global estimates of diabetes prevalence for 2013 and projections for 2035. , 2014, Diabetes Research and Clinical Practice.

[30]  F. Bäckhed,et al.  Microbiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural Circuits , 2014, Cell.

[31]  Yun-Cai Liu,et al.  The ubiquitin system in immune regulation. , 2014, Advances in immunology.

[32]  Heping Zhang,et al.  Microbiota associated with type 2 diabetes and its related complications , 2013 .

[33]  Zhuye Jie,et al.  Human Gut Microbiota Changes Reveal the Progression of Glucose Intolerance , 2013, PloS one.

[34]  Andre Pascal Kengne,et al.  Diabetes Mellitus and Inflammation , 2013, Current Diabetes Reports.

[35]  D. Sinderen,et al.  Molecular dialogue between the human gut microbiota and the host: a Lactobacillus and Bifidobacterium perspective , 2013, Cellular and Molecular Life Sciences.

[36]  M. Delledonne,et al.  Exploration of the Genomic Diversity and Core Genome of the Bifidobacterium adolescentis Phylogenetic Group by Means of a Polyphasic Approach , 2012, Applied and Environmental Microbiology.

[37]  M. Shiau,et al.  Regulation of glucose/lipid metabolism and insulin sensitivity by interleukin-4 , 2012, International Journal of Obesity.

[38]  K. Sivieri,et al.  Effect of the consumption of a new symbiotic shake on glycemia and cholesterol levels in elderly people with type 2 diabetes mellitus , 2012, Lipids in Health and Disease.

[39]  Jinjin Chen,et al.  Bifidobacterium adolescentis supplementation ameliorates visceral fat accumulation and insulin sensitivity in an experimental model of the metabolic syndrome , 2011, British Journal of Nutrition.

[40]  S. Garland Short chain fatty acids may elicit an innate immune response from preadipocytes: a potential link between bacterial infection and inflammatory diseases. , 2011, Medical hypotheses.

[41]  W. Cefalu,et al.  Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice , 2009, Diabetes.

[42]  Q. Mekki,et al.  Pharmacokinetic, pharmacodynamic, and tolerability profiles of the dipeptidyl peptidase-4 inhibitor alogliptin: a randomized, double-blind, placebo-controlled, multiple-dose study in adult patients with type 2 diabetes. , 2008, Clinical therapeutics.

[43]  S. Ball,et al.  Glycogen Phosphorylase, the Product of the glgP Gene, Catalyzes Glycogen Breakdown by Removing Glucose Units from the Nonreducing Ends in Escherichia coli , 2006, Journal of bacteriology.

[44]  Colin Mathers,et al.  Comparative Quantification of Mortality and Burden of Disease Attributable to Selected Risk Factors , 2006 .