Deep-UV surface-enhanced resonance Raman scattering of adenine on aluminum nanoparticle arrays.

We report the ultrasensitive detection of adenine using deep-UV surface-enhanced resonance Raman scattering on aluminum nanostructures. Well-defined Al nanoparticle arrays fabricated over large areas using extreme-UV interference lithography exhibited sharp and tunable plasmon resonances in the UV and deep-UV wavelength ranges. Theoretical modeling based on the finite-difference time-domain method was used to understand the near-field and far-field optical properties of the nanoparticle arrays. Raman measurements were performed on adenine molecules coated uniformly on the Al nanoparticle arrays at a laser excitation wavelength of 257.2 nm. With this technique, less than 10 amol of label-free adenine molecules could be detected reproducibly in real time. Zeptomole (~30,000 molecules) detection sensitivity was readily achieved proving that deep-UV surface-enhanced resonance Raman scattering is an extremely sensitive tool for the detection of biomolecules.

[1]  Yasin Ekinci,et al.  Sub-10 nm patterning using EUV interference lithography , 2011, Nanotechnology.

[2]  Zhilin Yang,et al.  Deep ultraviolet tip-enhanced Raman scattering. , 2011, Chemical communications.

[3]  S. Kawata,et al.  Deep UV resonant Raman spectroscopy for photodamage characterization in cells , 2011, Biomedical optics express.

[4]  Zhong-Qun Tian,et al.  Tunable SERS from aluminium nanohole arrays in the ultraviolet region. , 2011, Chemical communications.

[5]  M. Barbatti,et al.  The UV absorption of nucleobases: semi-classical ab initio spectra simulations. , 2010, Physical chemistry chemical physics : PCCP.

[6]  Yasin Ekinci,et al.  Magnetic metamaterials in the blue range using aluminum nanostructures. , 2009, Optics letters.

[7]  P. Etchegoin,et al.  Single-molecule surface-enhanced Raman spectroscopy of nonresonant molecules. , 2009, Journal of the American Chemical Society.

[8]  S. Kawata,et al.  Deep-UV tip-enhanced Raman scattering , 2009 .

[9]  S. Asher,et al.  Dependence of the AmII'p proline Raman band on peptide conformation. , 2009, The journal of physical chemistry. B.

[10]  Yu Kay Law,et al.  DNA excited-state dynamics: from single bases to the double helix. , 2009, Annual review of physical chemistry.

[11]  Mathieu Kociak,et al.  Zeptomol detection through controlled ultrasensitive surface-enhanced Raman scattering. , 2009, Journal of the American Chemical Society.

[12]  James Pond,et al.  Aluminum nanoparticles as substrates for metal-enhanced fluorescence in the ultraviolet for the label-free detection of biomolecules. , 2009, Analytical chemistry.

[13]  Ahmad Mohammadi,et al.  Gold, Copper, Silver and Aluminum Nanoantennas to Enhance Spontaneous Emission , 2008, 0807.4082.

[14]  H. Solak,et al.  Plasmon resonances of aluminum nanoparticles and nanorods , 2008 .

[15]  G. Schatz,et al.  Localized Surface Plasmon Resonance Spectroscopy of Triangular Aluminum Nanoparticles , 2008 .

[16]  Igor Zorić,et al.  Localized surface plasmon resonances in aluminum nanodisks. , 2008, Nano letters.

[17]  Freek Ariese,et al.  Achievements in resonance Raman spectroscopy review of a technique with a distinct analytical chemistry potential. , 2008, Analytica chimica acta.

[18]  M. Schmitt,et al.  Deep-UV surface-enhanced Raman scattering , 2007 .

[19]  K Baumann,et al.  Characterization of bacterial growth and the influence of antibiotics by means of UV resonance Raman spectroscopy. , 2006, Biopolymers.

[20]  Katrin Kneipp,et al.  Surface-enhanced Raman scattering , 2006 .

[21]  S. Asher,et al.  UV-resonance raman thermal unfolding study of Trp-cage shows that it is not a simple two-state miniprotein. , 2005, Journal of the American Chemical Society.

[22]  Fang Yan,et al.  Raman and surface Raman spectroscopy with ultraviolet excitation. , 2005, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

[23]  Zhilin Yang,et al.  Surface‐enhanced Raman spectroscopy with ultraviolet excitation , 2005 .

[24]  Zhilin Yang,et al.  Surface-enhanced Raman scattering in the ultraviolet spectral region: UV-SERS on rhodium and ruthenium electrodes. , 2003, Journal of the American Chemical Society.

[25]  Derek A. Long,et al.  The Raman Effect , 2002 .

[26]  Bernd Giese,et al.  Surface-Enhanced Raman Spectroscopic and Density Functional Theory Study of Adenine Adsorption to Silver Surfaces , 2002 .

[27]  Hongxing Xu,et al.  Interparticle coupling effects in nanofabricated substrates for surface-enhanced Raman scattering , 2001 .

[28]  J. Lindsey,et al.  PhotochemCAD ‡ : A Computer‐Aided Design and Research Tool in Photochemistry , 1998 .

[29]  R. Dasari,et al.  Single Molecule Detection Using Surface-Enhanced Raman Scattering (SERS) , 1997 .

[30]  Steven R. Emory,et al.  Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering , 1997, Science.

[31]  Howard Huang,et al.  Surface-Enhanced Raman Scattering of Adenine, Adenosine and ATP Molecules , 1987 .

[32]  Thomas G. Spiro,et al.  Ultraviolet resonance Raman spectroscopy of DNA with 200-266-nm laser excitation , 1986 .

[33]  S. Asher,et al.  Raman spectroscopy of a coal liquid shows that fluorescence interference is minimized with ultraviolet excitation. , 1984, Science.

[34]  T Yamada,et al.  Vacuum ultraviolet absorption spectra of sublimed films of nucleic acid bases , 1968, Biopolymers.