Molecular imaging of late somatostatin receptor-positive metastases of renal cell carcinoma in the pancreas by 68Ga DOTATOC PET/CT: a rare differential diagnosis to multiple primary pancreatic neuroendocrine tumors.

Ga somatostatin receptor PET/CT, currently the most sensitive imaging modality for well-differentiated neuroendocrine tumors, is based on the molecular imaging of somatostatin receptors (SSTRs) that are expressed in different tumor entities such as neuroendocrine neoplasms, lymphomas, meningiomas, or renal cell cancer (RCC). Most neuroendocrine neoplasms show a high expression of SSTR subtypes 2A and 5, whereas the overexpression of SSTR2A in RCC is mainly seen in peritumoral vessels. Here we report a case with strongly SSTR-positive pancreatic lesions detected by Ga DOTATOC PET/CT, which histologically turned out to be ultralate metastases of a RCC.

[1]  P. Castaldi,et al.  Role of PET/CT in the functional imaging of endocrine pancreatic tumors , 2012, Abdominal Imaging.

[2]  S. Schulz,et al.  Molecular imaging with 68Ga-SSTR PET/CT and correlation to immunohistochemistry of somatostatin receptors in neuroendocrine tumours , 2011, European Journal of Nuclear Medicine and Molecular Imaging.

[3]  S. Schulz,et al.  Reassessment of sst2 somatostatin receptor expression in human normal and neoplastic tissues using the novel rabbit monoclonal antibody UMB-1. , 2008, The Journal of clinical endocrinology and metabolism.

[4]  G. Haroske,et al.  Therapie von Pankreasmetastasen beim Nierenzellkarzinom - Eine Fallbeschreibung von 5 Patienten , 2006 .

[5]  O. Basturk,et al.  Secondary tumors of the pancreas: an analysis of a surgical and autopsy database and review of the literature , 2004, Virchows Archiv.

[6]  S. Schulz,et al.  Localization of five somatostatin receptors in the rat central nervous system using subtype-specific antibodies , 2000, Journal of Physiology-Paris.

[7]  A. Sundin,et al.  Imaging of Neuroendocrine Tumors. , 2016, Frontiers of hormone research.

[8]  G. Haroske,et al.  [Management of pancreatic metastases from renal cell carcinoma report of five cases]. , 2006, Zentralblatt fur Chirurgie.

[9]  J. Laissue,et al.  Somatostatin receptor sst1–sst5 expression in normal and neoplastic human tissues using receptor autoradiography with subtype-selective ligands , 2001, European Journal of Nuclear Medicine.

[10]  J. Reubi,et al.  Expression of somatostatin receptors in peritumoral veins of human tumors , 1999, Cancer.