Modeling the role of p 53 pulses in DNA damage-induced cell death decision

[1]  Ming Liu,et al.  Cell cycle checkpoint signaling through the ATR and ATM kinases , 2010, The 2nd International Conference on Information Science and Engineering.

[2]  Tomasz Lipniacki,et al.  Oscillations and bistability in the stochastic model of p53 regulation. , 2008, Journal of theoretical biology.

[3]  Carole J. Proctor,et al.  Explaining oscillations and variability in the p53-Mdm2 system , 2008, BMC Systems Biology.

[4]  G. Lahav,et al.  Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage. , 2008, Molecular cell.

[5]  Tingzhe Sun,et al.  Two Independent Positive Feedbacks and Bistability in the Bcl-2 Apoptotic Switch , 2008, PloS one.

[6]  J. Bartek,et al.  DNA Damage Response as an Anti-Cancer Barrier: Damage Threshold and the Concept of 'Conditional Haploinsufficiency' , 2007, Cell cycle.

[7]  G. Pelosi,et al.  Complex engagement of DNA damage response pathways in human cancer and in lung tumor progression. , 2007, Carcinogenesis.

[8]  Rui Wang,et al.  Modeling of the role of a Bax-activation switch in the mitochondrial apoptosis decision. , 2007, Biophysical journal.

[9]  L. Trinkle-Mulcahy,et al.  Emerging roles of nuclear protein phosphatases , 2007, Nature Reviews Molecular Cell Biology.

[10]  Ali Nadim,et al.  A Model for p53 Dynamics Triggered by DNA Damage , 2007, SIAM J. Appl. Dyn. Syst..

[11]  Paul Brazhnik,et al.  Exploring Mechanisms of the DNA-Damage Response: p53 Pulses and their Possible Relevance to Apoptosis , 2007, Cell cycle.

[12]  J. Hsieh,et al.  Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies , 2006, Nature Cell Biology.

[13]  Keng Boon Wee,et al.  Akt versus p53 in a network of oncogenes and tumor suppressor genes regulating cell survival and death. , 2006, Biophysical journal.

[14]  Wafik S El-Deiry,et al.  p73 or p53 directly regulates human p53 transcription to maintain cell cycle checkpoints. , 2006, Cancer research.

[15]  R. Milo,et al.  Oscillations and variability in the p53 system , 2006, Molecular systems biology.

[16]  D. Green,et al.  Dissecting p53-dependent apoptosis , 2006, Cell Death and Differentiation.

[17]  Xiao-Ming Yin Bid, a BH3-only multi-functional molecule, is at the cross road of life and death. , 2006, Gene.

[18]  B. Dörken,et al.  Induction of p21CIP/WAF-1 and G2 arrest by ionizing irradiation impedes caspase-3-mediated apoptosis in human carcinoma cells , 2006, Oncogene.

[19]  Wei Gu,et al.  p53 ubiquitination: Mdm2 and beyond. , 2006, Molecular cell.

[20]  Y. Yen,et al.  The role of peroxiredoxin II in radiation-resistant MCF-7 breast cancer cells. , 2005, Cancer research.

[21]  J. Ferrell,et al.  Interlinked Fast and Slow Positive Feedback Loops Drive Reliable Cell Decisions , 2005, Science.

[22]  John Jeremy Rice,et al.  A plausible model for the digital response of p53 to DNA damage. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[23]  A. Letai Pharmacological manipulation of Bcl-2 family members to control cell death. , 2005, The Journal of clinical investigation.

[24]  T. Kuwana,et al.  PUMA Couples the Nuclear and Cytoplasmic Proapoptotic Function of p53 , 2005, Science.

[25]  K. Manova,et al.  Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models , 2005, Nature Cell Biology.

[26]  E. Stavridi,et al.  Nbs1 moving up in the world , 2005, Nature Cell Biology.

[27]  Ji-Hoon Lee,et al.  ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex , 2005, Science.

[28]  A. Levine,et al.  The p53 pathway: positive and negative feedback loops , 2005, Oncogene.

[29]  J. Bartek,et al.  ATM Activation in Normal Human Tissues and Testicular Cancer , 2005, Cell cycle.

[30]  Andrea Ciliberto,et al.  Steady States and Oscillations in the p53/Mdm2 Network , 2005, Cell cycle.

[31]  C. Harris,et al.  p53: traffic cop at the crossroads of DNA repair and recombination , 2005, Nature Reviews Molecular Cell Biology.

[32]  S. Lowe,et al.  Intrinsic tumour suppression , 2004, Nature.

[33]  K. Khanna,et al.  Autophosphorylation of ataxia‐telangiectasia mutated is regulated by protein phosphatase 2A , 2004, The EMBO journal.

[34]  A. Murtha,et al.  Low-dose radiation hypersensitivity is associated with p53-dependent apoptosis. , 2004, Molecular cancer research : MCR.

[35]  F. Allgöwer,et al.  Bistability Analyses of a Caspase Activation Model for Receptor-induced Apoptosis* , 2004, Journal of Biological Chemistry.

[36]  S. Lees-Miller,et al.  DNA damage-induced activation of ATM and ATM-dependent signaling pathways. , 2004, DNA repair.

[37]  U. Moll,et al.  In Vivo Mitochondrial p53 Translocation Triggers a Rapid First Wave of Cell Death in Response to DNA Damage That Can Precede p53 Target Gene Activation , 2004, Molecular and Cellular Biology.

[38]  Alexander E. Kel,et al.  Bifurcation analysis of the regulatory modules of the mammalian G1/S transition , 2004, Bioinform..

[39]  N. Fujiuchi,et al.  Requirement of IFI16 for the Maximal Activation of p53 Induced by Ionizing Radiation* , 2004, Journal of Biological Chemistry.

[40]  G. Wahl,et al.  Accelerated MDM2 auto‐degradation induced by DNA‐damage kinases is required for p53 activation , 2004, The EMBO journal.

[41]  W. Hahn,et al.  Identification of specific PP2A complexes involved in human cell transformation. , 2004, Cancer cell.

[42]  John J Tyson,et al.  Monitoring p53's pulse , 2004, Nature Genetics.

[43]  Uri Alon,et al.  Dynamics of the p53-Mdm2 feedback loop in individual cells , 2004, Nature Genetics.

[44]  U. Knippschild,et al.  Posttranslational modification of MDM2. , 2003, Molecular cancer research : MCR.

[45]  T. Kuwana,et al.  Bcl-2-family proteins and the role of mitochondria in apoptosis. , 2003, Current opinion in cell biology.

[46]  J. Cleveland,et al.  Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. , 2003, Cancer cell.

[47]  U. Alon Biological Networks: The Tinkerer as an Engineer , 2003, Science.

[48]  N. Monk Oscillatory Expression of Hes1, p53, and NF-κB Driven by Transcriptional Time Delays , 2003, Current Biology.

[49]  K. Kinzler,et al.  PUMA mediates the apoptotic response to p53 in colorectal cancer cells , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[50]  M. Kastan,et al.  DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation , 2003, Nature.

[51]  Jiri Bartek,et al.  53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer , 2002, Nature Cell Biology.

[52]  Ronald A. DePinho,et al.  p53: good cop/bad cop. , 2002, Cell.

[53]  W. El-Deiry,et al.  Apoptotic threshold is lowered by p53 transactivation of caspase-6 , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[54]  A. Goldbeter,et al.  Robustness of circadian rhythms with respect to molecular noise , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[55]  R. Abraham Cell cycle checkpoint signaling through the ATM and ATR kinases. , 2001, Genes & development.

[56]  I. H. Engels,et al.  Ionizing radiation but not anticancer drugs causes cell cycle arrest and failure to activate the mitochondrial death pathway in MCF-7 breast carcinoma cells , 2001, Oncogene.

[57]  E. Appella,et al.  Post-translational modifications and activation of p53 by genotoxic stresses. , 2001, European journal of biochemistry.

[58]  M. Hengartner The biochemistry of apoptosis , 2000, Nature.

[59]  U Alon,et al.  Generation of oscillations by the p53-Mdm2 feedback loop: a theoretical and experimental study. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[60]  V. Adler,et al.  Mdm2 association with p53 targets its ubiquitination , 1998, Oncogene.

[61]  J. Minna,et al.  Alterations of the PPP2R1B gene in human lung and colon cancer. , 1998, Science.

[62]  M. Olivier,et al.  Relaxed cell‐cycle arrests and propagation of unrepaired chromosomal damage in cancer cell lines with wild‐type p53 , 1998, Molecular carcinogenesis.

[63]  M. Löbrich,et al.  Repair of x-ray-induced DNA double-strand breaks in specific Not I restriction fragments in human fibroblasts: joining of correct and incorrect ends. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[64]  V. Reinke,et al.  The tumor suppressor p53 regulates its own transcription , 1993, Molecular and cellular biology.