Dispensable role of Rac1 and Rac3 after cochlear hair cell specification

[1]  Naoaki Saito,et al.  Nox3-Derived Superoxide in Cochleae Induces Sensorineural Hearing Loss , 2021, The Journal of Neuroscience.

[2]  Bernd Fritzsch,et al.  Development in the Mammalian Auditory System Depends on Transcription Factors , 2021, International journal of molecular sciences.

[3]  D. Corey,et al.  AAV-S: A versatile capsid variant for transduction of mouse and primate inner ear , 2021, Molecular therapy. Methods & clinical development.

[4]  V. Lougaris,et al.  RAC2 and primary human immune deficiencies , 2020, Journal of leukocyte biology.

[5]  S. Tangye,et al.  Systemic Inflammation and Myelofibrosis in a Patient with Takenouchi-Kosaki Syndrome due to CDC42 Tyr64Cys Mutation , 2020, Journal of Clinical Immunology.

[6]  Bernd Fritzsch,et al.  Early ear neuronal development, but not olfactory or lens development, can proceed without SOX2. , 2020, Developmental biology.

[7]  Xiaowei Lu,et al.  New insights into regulation and function of planar polarity in the inner ear , 2019, Neuroscience Letters.

[8]  Mitsuhiro Kato,et al.  A de novo variant in RAC3 causes severe global developmental delay and a middle interhemispheric variant of holoprosencephaly , 2019, Journal of Human Genetics.

[9]  Dongseok Choi,et al.  Mechanotransduction-Dependent Control of Stereocilia Dimensions and Row Identity in Inner Hair Cells , 2019, Current Biology.

[10]  S. Holland,et al.  Dominant activating RAC2 mutation with lymphopenia, immunodeficiency, and cytoskeletal defects. , 2019, Blood.

[11]  S. Mitani,et al.  Pathogenetic basis of Takenouchi-Kosaki syndrome: Electron microscopy study using platelets in patients and functional studies in a Caenorhabditis elegans model , 2019, Scientific Reports.

[12]  T. Ueyama.  Rho-Family Small GTPases: From Highly Polarized Sensory Neurons to Cancer Cells , 2019, Cells.

[13]  A. Aiba,et al.  Rac-dependent signaling from keratinocytes promotes differentiation of intradermal white adipocytes , 2018, bioRxiv.

[14]  S. Scherer,et al.  De novo missense variants in RAC3 cause a novel neurodevelopmental syndrome , 2018, Genetics in Medicine.

[15]  Douglas P. Larsen,et al.  Functional Dysregulation of CDC42 Causes Diverse Developmental Phenotypes. , 2018, American journal of human genetics.

[16]  Ronald Cohn,et al.  RAC1 Missense Mutations in Developmental Disorders with Diverse Phenotypes. , 2017, American journal of human genetics.

[17]  M. Georgiou,et al.  An apicobasal gradient of Rac activity determines protrusion form and position , 2017, Nature Communications.

[18]  H. Kiyonari,et al.  Novel role of Rac-Mid1 signaling in medial cerebellar development , 2017, Development.

[19]  N. Watanabe,et al.  Constitutive activation of DIA1 (DIAPH1) via C‐terminal truncation causes human sensorineural hearing loss , 2016, EMBO molecular medicine.

[20]  Patrick J Atkinson,et al.  Sensory hair cell development and regeneration: similarities and differences , 2015, Development.

[21]  J. Lipski,et al.  Kölliker's Organ and the Development of Spontaneous Activity in the Auditory System: Implications for Hearing Dysfunction , 2014, BioMed research international.

[22]  Christine Petit,et al.  Genetics of auditory mechano-electrical transduction , 2014, Pflügers Archiv - European Journal of Physiology.

[23]  Takashi Nakamura,et al.  Maintenance of stereocilia and apical junctional complexes by Cdc42 in cochlear hair cells , 2014, Journal of Cell Science.

[24]  Bernd Fritzsch,et al.  Atoh1 directs hair cell differentiation and survival in the late embryonic mouse inner ear. , 2013, Developmental biology.

[25]  J. Bok,et al.  Auditory ganglion source of Sonic hedgehog regulates timing of cell cycle exit and differentiation of mammalian cochlear hair cells , 2013, Proceedings of the National Academy of Sciences.

[26]  A. Groves,et al.  Conditional Deletion of Atoh1 Reveals Distinct Critical Periods for Survival and Function of Hair Cells in the Organ of Corti , 2013, The Journal of Neuroscience.

[27]  Bernd Fritzsch,et al.  Continued Expression of GATA3 Is Necessary for Cochlear Neurosensory Development , 2013, PLoS ONE.

[28]  M. Kelley,et al.  The Atoh1-lineage gives rise to hair cells and supporting cells within the mammalian cochlea. , 2013, Developmental biology.

[29]  Keisuke Ito,et al.  GDNF and Endothelin 3 Regulate Migration of Enteric Neural Crest-Derived Cells via Protein Kinase A and Rac1 , 2013, The Journal of Neuroscience.

[30]  Bernd Fritzsch,et al.  Correct Timing of Proliferation and Differentiation is Necessary for Normal Inner Ear Development and Auditory Hair Cell Viability , 2013, Developmental dynamics : an official publication of the American Association of Anatomists.

[31]  M. Kelley,et al.  Molecular mechanisms of inner ear development. , 2012, Cold Spring Harbor perspectives in biology.

[32]  J. Zuo,et al.  Conditional Gene Expression in the Mouse Inner Ear Using Cre-loxP , 2012, Journal of the Association for Research in Otolaryngology.

[33]  M. Matsuda,et al.  Suppression of Rac1 activity at the apical membrane of MDCK cells is essential for cyst structure maintenance , 2012, EMBO reports.

[34]  Doris K. Wu,et al.  Redundant functions of Rac GTPases in inner ear morphogenesis. , 2012, Developmental biology.

[35]  Bernd Fritzsch,et al.  Canal Cristae Growth and Fiber Extension to the Outer Hair Cells of the Mouse Ear Require Prox1 Activity , 2010, PloS one.

[36]  Xiaowei Lu,et al.  The Small GTPase Rac1 Regulates Auditory Hair Cell Morphogenesis , 2009, The Journal of Neuroscience.

[37]  J. Bok,et al.  Patterning and morphogenesis of the vertebrate inner ear. , 2007, The International journal of developmental biology.

[38]  Kevin A. Burns,et al.  Rac1 Controls the Formation of Midline Commissures and the Competency of Tangential Migration in Ventral Telencephalic Neurons , 2007, The Journal of Neuroscience.

[39]  M. Kelley.  Regulation of cell fate in the sensory epithelia of the inner ear , 2006, Nature Reviews Neuroscience.

[40]  Mark E. Schneider,et al.  A New Compartment at Stereocilia Tips Defined by Spatial and Temporal Patterns of Myosin IIIa Expression , 2006, The Journal of Neuroscience.

[41]  D. Rowitch,et al.  Smaller inner ear sensory epithelia in Neurog1 null mice are related to earlier hair cell cycle exit , 2005, Developmental dynamics : an official publication of the American Association of Anatomists.

[42]  Toshihiro Kobayashi,et al.  Isoform-Specific Membrane Targeting Mechanism of Rac during FcγR-Mediated Phagocytosis: Positive Charge-Dependent and Independent Targeting Mechanism of Rac to the Phagosome1 , 2005, The Journal of Immunology.

[43]  L. Croci,et al.  Generation and Characterization of Rac3 Knockout Mice , 2005, Molecular and Cellular Biology.

[44]  A. Groves,et al.  Generation of Pax2‐Cre mice by modification of a Pax2 bacterial artificial chromosome , 2004, Genesis.

[45]  Yehoash Raphael,et al.  Claudin 14 knockout mice, a model for autosomal recessive deafness DFNB29, are deaf due to cochlear hair cell degeneration. , 2003, Human molecular genetics.

[46]  H. Zoghbi,et al.  The role of Math1 in inner ear development: Uncoupling the establishment of the sensory primordium from hair cell fate determination. , 2002, Development.

[47]  John Sondek,et al.  A crystallographic view of interactions between Dbs and Cdc42: PH domain‐assisted guanine nucleotide exchange , 2002, The EMBO journal.

[48]  S. Mcconnell,et al.  Targeting of cre to the Foxg1 (BF-1) locus mediates loxP recombination in the telencephalon and other developing head structures. , 2000, Developmental biology.

[49]  Bassem A. Hassan,et al.  Math1: an essential gene for the generation of inner ear hair cells. , 1999, Science.