Effects of apolipoprotein E (apoE) isoforms, β-amyloid (Aβ) and apoE/Aβ complexes on Protein Kinase C-α (PKC-α) translocation and amyloid precursor protein (APP) processing in human SH-SY5Y neuroblastoma cells and fibroblasts

[1]  S. Paul,et al.  Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[2]  B. Winblad,et al.  Nicergoline stimulates protein kinase C mediated α-secretase processing of the amyloid precursor protein in cultured human neuroblastoma SH-SY5Y cells , 1999, Neurochemistry International.

[3]  P. Reiner,et al.  Regulation of Amyloid Precursor Protein Cleavage , 1999, Journal of neurochemistry.

[4]  A. Goate,et al.  Risk for Alzheimer's disease correlates with transcriptional activity of the APOE gene. , 1998, Human molecular genetics.

[5]  W. März,et al.  Apolipoprotein E Isoforms Increase Intracellular Ca2+ Differentially Through a ω‐Agatoxin IVa‐Sensitive Ca2+‐Channel , 1998, Brain pathology.

[6]  E. Corder,et al.  The role of APOE polymorphisms in late-onset dementias , 1998, Cellular and Molecular Life Sciences CMLS.

[7]  K. Beyreuther,et al.  Physical interaction of ApoE with amyloid precursor protein independent of the amyloid Abeta region in vitro. , 1998, The Journal of biological chemistry.

[8]  D. Alkon,et al.  Alzheimer's-specific effects of soluble beta-amyloid on protein kinase C-alpha and -gamma degradation in human fibroblasts. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[9]  A. Roses,et al.  Apolipoprotein E and the CNS Response to Injury , 1998, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[10]  A. LeBlanc,et al.  Protein Kinase C Activation Increases Release of Secreted Amyloid Precursor Protein without Decreasing Aβ Production in Human Primary Neuron Cultures. , 1998, The Journal of Neuroscience.

[11]  J. Poirier,et al.  β‐Amyloid Peptides Increase the Binding and Internalization of Apolipoprotein E to Hippocampal Neurons , 1998, Journal of neurochemistry.

[12]  F. Pasquier,et al.  A new polymorphism in the APOE promoter associated with risk of developing Alzheimer's disease. , 1998, Human molecular genetics.

[13]  B. Permanne,et al.  Detection of apolipoprotein E/dimeric soluble amyloid beta complexes in Alzheimer's disease brain supernatants. , 1997, Biochemical and biophysical research communications.

[14]  T. Sunderland,et al.  Physiological levels of β-amyloid peptide stimulate protein kinase C in PC12 cells , 1997, Brain Research.

[15]  T. Schmitt,et al.  Amyloid β-Protein25-35Increases Cellular APP and Inhibits the Secretion of APPs in Human Extraneuronal Cells , 1997 .

[16]  B. Austen,et al.  Metabolites of the β‐amyloid precursor protein generated by β‐secretase localise to the trans‐golgi network and late endosome in 293 cells , 1996 .

[17]  T. Taniguchi,et al.  Ca2+‐Dependent and Ca2+‐Independent Protein Kinase C Changes in the Brains of Patients with Alzheimer's Disease , 1996, Journal of neurochemistry.

[18]  K. Goto,et al.  Human Apolipoprotein E Receptor 2 , 1996, The Journal of Biological Chemistry.

[19]  T. Sunderland,et al.  Differential Regulation of APP Secretion by Apolipoprotein E3 and E4 a , 1996, Annals of the New York Academy of Sciences.

[20]  S. Appel,et al.  β‐Amyloid1–40 Increases Expression of β‐Amyloid Precursor Protein in Neuronal Hybrid Cells , 1995 .

[21]  F. Checler.  Processing of the β‐Amyloid Precursor Protein and Its Regulation in Alzheimer's Disease , 1995 .

[22]  C. Cotman,et al.  Amyloid β‐Protein Induces Its Own Production in Cultured Degenerating Cerebrovascular Smooth Muscle Cells , 1995 .

[23]  D. Selkoe,et al.  Co-expression of β-amyloid precursor protein (βAPP) and apolipoprotein E in cell culture: analysis of βAPP processing , 1995, Neurobiology of Disease.

[24]  H. Sorimachi,et al.  Conventional protein kinase C (PKC)‐α and novel PKCε, but not ‐δ, increase the secretion of an N‐terminal fragment of Alzheimer's disease amyloid precursor protein from PKC cDNA transfected 3Y1 fibroblasts , 1995 .

[25]  G. Getz,et al.  Purification of Apolipoprotein E Attenuates Isoform-specific Binding to -Amyloid (*) , 1995, The Journal of Biological Chemistry.

[26]  E. Matsubara,et al.  The soluble form of Alzheimer's amyloid beta protein is complexed to high density lipoprotein 3 and very high density lipoprotein in normal human plasma. , 1994, Biochemical and biophysical research communications.

[27]  V. Tkachuk,et al.  Atypical low density lipoprotein binding site that may mediate lipoprotein-induced signal transduction. , 1994, Molecular pharmacology.

[28]  T Vogel,et al.  Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro. , 1994, The American journal of pathology.

[29]  G. Getz,et al.  Isoform-specific binding of apolipoprotein E to beta-amyloid. , 1994, The Journal of biological chemistry.

[30]  K. Beyreuther,et al.  Amyloid precursor protein secretion and βA4 amyloid generation are not mutually exclusive , 1994, FEBS letters.

[31]  W. Müller,et al.  Apolipoprotein E and cholesterol affect neuronal calcium signalling: the possible relationship to beta-amyloid neurotoxicity. , 1994, Biochemical and biophysical research communications.

[32]  Hoau Yan Wang,et al.  Attenuated protein kinase C activity and translocation in Alzheimer's Disease brain , 1994, Neurobiology of Aging.

[33]  Margaret A. Pericak-Vance,et al.  Hypothesis: Microtubule Instability and Paired Helical Filament Formation in the Alzheimer Disease Brain Are Related to Apolipoprotein E Genotype , 1994, Experimental Neurology.

[34]  K. Beyreuther,et al.  Amyloid-like properties of peptides flanking the epitope of amyloid precursor protein-specific monoclonal antibody 22C11. , 1993, The Journal of biological chemistry.

[35]  B. Yankner,et al.  Inhibition of β‐Amyloid Production by Activation of Protein Kinase C , 1993 .

[36]  A D Roses,et al.  Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[37]  P. Greengard,et al.  Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[38]  B. Hyman,et al.  Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions , 1993, Neuron.

[39]  M. Pericak-Vance,et al.  Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[40]  R. Wurtman,et al.  Regulation of Amyloid Precursor Protein Release By Protein Kinase C in Swiss 3T3 Fibroblasts a , 1993, Annals of the New York Academy of Sciences.

[41]  M. Pericak-Vance,et al.  Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[42]  Y. Kawarabayasi,et al.  Rabbit very low density lipoprotein receptor: a low density lipoprotein receptor-like protein with distinct ligand specificity. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[43]  Thomas Wisniewski,et al.  Apolipoprotein E: A pathological chaperone protein in patients with cerebral and systemic amyloid , 1992, Neuroscience Letters.

[44]  D. Selkoe,et al.  Homology of the amyloid beta protein precursor in monkey and human supports a primate model for beta amyloidosis in Alzheimer's disease. , 1991, The American journal of pathology.

[45]  E. Masliah,et al.  Differential involvement of protein kinase C isozymes in Alzheimer's disease , 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[46]  U. Beisiegel,et al.  The LDL–receptor–related protein, LRP, is an apolipoprotein E-binding protein , 1989, Nature.

[47]  Andreas Weidemann,et al.  Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein , 1989, Cell.

[48]  Y. Nishizuka,et al.  Limited proteolysis of protein kinase C subspecies by calcium-dependent neutral protease (calpain). , 1989, The Journal of biological chemistry.

[49]  R. Mahley,et al.  Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. , 1988, Science.

[50]  R. E. Pitas,et al.  Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain. , 1987, The Journal of biological chemistry.

[51]  M. Brown,et al.  Saturation and suppression of hepatic lipoprotein receptors: a mechanism for the hypercholesterolemia of cholesterol-fed rabbits. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[52]  M. M. Bradford.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. , 1976, Analytical biochemistry.

[53]  U. K. Laemmli,et al.  Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4 , 1970, Nature.

[54]  D. Michaelson,et al.  Secretion of the amyloid precursor protein is elevated isoform specifically by apolipoprotein E4. , 2000, Journal of neural transmission. Supplementum.

[55]  W. März,et al.  Competition of Abeta amyloid peptide and apolipoprotein E for receptor-mediated endocytosis. , 1999, Journal of lipid research.

[56]  J. Morris,et al.  A polymorphism in the regulatory region of APOE associated with risk for Alzheimer's dementia , 1998, Nature Genetics.

[57]  H. Wiśniewski,et al.  Action of amyloid beta-protein on protein kinase C activity. , 1991, Life sciences.