Comparison of clinical and molecular surveillance in patients with advanced nasopharyngeal carcinoma after primary therapy

The importance of detecting recurrence at an early stage in patients with malignant disease is well recognized. Circulating Epstein–Barr virus (EBV) DNA can be detected in patients with nasopharyngeal carcinoma (NPC). The objective of the current study was to assess the effectiveness of plasma EBV DNA monitoring in the early detection of NPC recurrence compared with conventional methods.

[1]  G. Lyman,et al.  Evaluation of an intensive strategy for follow-up and surveillance of primary breast cancer , 1998, Annals of Surgical Oncology.

[2]  Laurence L. George,et al.  The Statistical Analysis of Failure Time Data , 2003, Technometrics.

[3]  V. Leb,et al.  Parallel detection of five human herpes virus DNAs by a set of real-time polymerase chain reactions in a single run. , 2003, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.

[4]  S. Leung,et al.  Plasma Epstein-Barr virus DNA and residual disease after radiotherapy for undifferentiated nasopharyngeal carcinoma. , 2002, Journal of the National Cancer Institute.

[5]  D. Nadal,et al.  Epstein‐Barr virus (EBV) DNA levels in palatine tonsils and autologous serum from EBV carriers , 2002, Journal of medical virology.

[6]  M. Egger,et al.  Impact on survival of intensive follow up after curative resection for colorectal cancer: systematic review and meta-analysis of randomised trials , 2002, BMJ : British Medical Journal.

[7]  K. Brengel-Pesce,et al.  Routine use of real‐time quantitative PCR for laboratory diagnosis of Epstein‐Barr virus infections , 2002, Journal of medical virology.

[8]  M. Lishner,et al.  Detection of relapse in non‐Hodgkin's lymphoma: Role of routine follow‐up studies , 2002, American journal of hematology.

[9]  C. J. Chen,et al.  Serologic markers of Epstein-Barr virus infection and nasopharyngeal carcinoma in Taiwanese men. , 2001, The New England journal of medicine.

[10]  P. Lou,et al.  Induction chemotherapy with mitomycin, epirubicin, cisplatin, fluorouracil, and leucovorin followed by radiotherapy in the treatment of locoregionally advanced nasopharyngeal carcinoma. , 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[11]  Yau-Huei Wei,et al.  Detection of Epstein-Barr virus DNA in the peripheral-blood cells of patients with nasopharyngeal carcinoma: relationship to distant metastasis and survival. , 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[12]  F. O. Fackelmayer,et al.  DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells. , 2001, Cancer research.

[13]  S. Leung,et al.  Molecular prognostication of nasopharyngeal carcinoma by quantitative analysis of circulating Epstein-Barr virus DNA. , 2000, Cancer research.

[14]  C. Wong,et al.  Salvage radiation therapy for locally recurrent nasopharyngeal carcinoma. , 2000, International journal of radiation oncology, biology, physics.

[15]  K. Fong,et al.  Diagnostic Value of Epstein-Barr Viral Serology in Nasopharyngeal Carcinoma , 2000, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[16]  S. Ng,et al.  Locally recurrent nasopharyngeal carcinoma. , 2000, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[17]  B C Stack,et al.  Surveillance for recurrent head and neck cancer using positron emission tomography. , 2000, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[18]  Y. Chao,et al.  Salvage surgery for recurrent nasopharyngeal carcinoma. , 1997, The Laryngoscope.

[19]  S. Leung,et al.  Quantitative and temporal correlation between circulating cell-free Epstein-Barr virus DNA and tumor recurrence in nasopharyngeal carcinoma. , 1999, Cancer research.

[20]  L. Ting,et al.  Induction with mitomycin C, doxorubicin, cisplatin and maintenance with weekly 5-fluorouracil, leucovorin for treatment of metastatic nasopharyngeal carcinoma: a phase II study , 1999, British Journal of Cancer.

[21]  T. Yen,et al.  Detection of recurrent or persistent nasopharyngeal carcinomas after radiotherapy with 18-fluoro-2-deoxyglucose positron emission tomography and comparison with computed tomography. , 1998, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[22]  J. Toouli,et al.  Yearly colonoscopy, liver CT, and chest radiography do not influence 5-year survival of colorectal cancer patients. , 1998, Gastroenterology.

[23]  Y. Chao,et al.  Salvage Surgery for Recurrent Nasopharyngeal Carcinoma , 2000, Archives of otolaryngology--head & neck surgery.

[24]  O. Kronborg,et al.  A prospective randomized study of follow‐up after radical surgery for colorectal cancer , 1997, The British journal of surgery.

[25]  S. Leung,et al.  Prognosticators determining survival subsequent to distant metastasis from nasopharyngeal carcinoma , 1996, Cancer.

[26]  M. Kairaluoma,et al.  Five-year follow-up after radical surgery for colorectal cancer. Results of a prospective randomized trial. , 1995, Archives of surgery.

[27]  C. Fallai,et al.  Staging and follow-up of nasopharyngeal carcinoma: magnetic resonance imaging versus computerized tomography. , 1995, International journal of radiation oncology, biology, physics.

[28]  H. Graffner,et al.  Follow-up after curative surgery for colorectal carcinoma , 1995, Diseases of the colon and rectum.

[29]  S. Ciatto,et al.  Intensive Diagnostic Follow-up After Treatment of Primary Breast Cancer: A Randomized Trial , 1994 .

[30]  M. Indelli,et al.  Impact of follow-up testing on survival and health-related quality of life in breast cancer patients. A multicenter randomized controlled trial. The GIVIO Investigators. , 1994, JAMA.

[31]  S. Ciatto,et al.  Intensive diagnostic follow-up after treatment of primary breast cancer. A randomized trial. National Research Council Project on Breast Cancer follow-up. , 1994, JAMA.

[32]  K. Nakagawa,et al.  Wide variation of probability of local failure and distant metastasis among various stages of patients with nasopharyngeal carcinoma. , 1994, Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al].

[33]  J. Sham,et al.  Value of clinical follow‐up for local nasopharyngeal carcinoma relapse , 1992, Head & neck.

[34]  S. Stefani,et al.  Distant metastases of nasopharyngeal carcinoma: A study of 256 male patients , 1986, Journal of surgical oncology.