An in vitro ischemic penumbral mimic perfusate increases NADPH oxidase-mediated superoxide production in cultured hippocampal neurons

[1]  P. Fraser.  The role of free radical generation in increasing cerebrovascular permeability. , 2011, Free radical biology & medicine.

[2]  T. Neumann-Haefelin,et al.  NADPH oxidase Nox1 contributes to ischemic injury in experimental stroke in mice , 2010, Neurobiology of Disease.

[3]  G. Haddad,et al.  DIDS protects against neuronal injury by blocking Toll‐like receptor 2 activated‐mechanisms , 2009, Journal of neurochemistry.

[4]  C. Sobey,et al.  NADPH oxidase activity is higher in cerebral versus systemic arteries of four animal species: role of Nox2. , 2009, American journal of physiology. Heart and circulatory physiology.

[5]  N. Cairns,et al.  Apocynin improves outcome in experimental stroke with a narrow dose range , 2008, Neuroscience.

[6]  E. Lo,et al.  A new penumbra: transitioning from injury into repair after stroke , 2008, Nature Medicine.

[7]  D. Kögel,et al.  Apoptosis meets autophagy-like cell death in the ischemic penumbra: Two sides of the same coin? , 2008, Autophagy.

[8]  A. Rami.  Upregulation of Beclin 1 in the ischemic penumbra , 2008, Autophagy.

[9]  T. Neumann-Haefelin,et al.  NADPH Oxidase Plays a Central Role in Blood-Brain Barrier Damage in Experimental Stroke , 2007, Stroke.

[10]  G. Haddad,et al.  Cell death in an ischemic infarct rim model , 2007, Journal of neurochemistry.

[11]  G. Aston-Jones,et al.  Selective Loss of Catecholaminergic Wake–Active Neurons in a Murine Sleep Apnea Model , 2007, The Journal of Neuroscience.

[12]  P. Kakkar,et al.  Mitochondria: a hub of redox activities and cellular distress control , 2007, Molecular and Cellular Biochemistry.

[13]  A. Fisher,et al.  Superoxide flux in endothelial cells via the chloride channel-3 mediates intracellular signaling. , 2007, Molecular biology of the cell.

[14]  Yousheng Shu,et al.  Factors influencing cell fate in the infarct rim , 2007, Journal of neurochemistry.

[15]  A. Barzilai.  The contribution of the DNA damage response to neuronal viability. , 2006, Antioxidants & redox signaling.

[16]  K. Liu,et al.  Cerebral tissue oxygenation and oxidative brain injury during ischemia and reperfusion. , 2007, Frontiers in bioscience : a journal and virtual library.

[17]  D. Kaufman,et al.  Atorvastatin protects against cerebral infarction via inhibition of NADPH oxidase-derived superoxide in ischemic stroke. , 2006, American journal of physiology. Heart and circulatory physiology.

[18]  Á. Simonyi,et al.  Apocynin protects against global cerebral ischemia–reperfusion-induced oxidative stress and injury in the gerbil hippocampus , 2006, Brain Research.

[19]  E. Ogier-Denis,et al.  Neuronal expression of the NADPH oxidase NOX4, and its regulation in mouse experimental brain ischemia , 2005, Neuroscience.

[20]  N. Takahashi,et al.  Chloride Channel Inhibition Prevents ROSdependentApoptosis Induced by Ischemia-Reperfusion in Mouse Cardiomyocytes , 2005, Cellular Physiology and Biochemistry.

[21]  Takahiro Shimizu,et al.  A role of reactive oxygen species in apoptotic activation of volume-sensitive Cl(-) channel. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[22]  S. Urano,et al.  ESR measurement of rapid penetration of DMPO and DEPMPO spin traps through lipid bilayer membranes. , 2003, Archives of biochemistry and biophysics.

[23]  P. Tordo,et al.  5-Diisopropoxyphosphoryl-5-methyl-1-pyrroline N-oxide, DIPPMPO, a crystalline analog of the nitrone DEPMPO: synthesis and spin trapping properties , 2002 .

[24]  Gary Fiskum,et al.  Generation of reactive oxygen species by the mitochondrial electron transport chain , 2002, Journal of neurochemistry.

[25]  E. Cadenas,et al.  Mitochondrial respiratory chain-dependent generation of superoxide anion and its release into the intermembrane space. , 2001, The Biochemical journal.

[26]  K. Stolze,et al.  Spin trapping of lipid radicals with DEPMPO-derived spin traps: detection of superoxide, alkyl and alkoxyl radicals in aqueous and lipid phase. , 2000, Free radical biology & medicine.

[27]  K. Stolze,et al.  Lipid radicals: properties and detection by spin trapping. , 2000, Acta biochimica Polonica.

[28]  A. Akaike,et al.  Reactive oxygen species in NMDA receptor-mediated glutamate neurotoxicity. , 1999, Parkinsonism & related disorders.

[29]  H. Swartz,et al.  Evaluation of DEPMPO as a spin trapping agent in biological systems. , 1999, Free radical biology & medicine.

[30]  M. Dinauer,et al.  Ischemic stroke injury is reduced in mice lacking a functional NADPH oxidase. , 1997, Stroke.

[31]  P. Nicotera,et al.  Intracellular Adenosine Triphosphate (ATP) Concentration: A Switch in the Decision Between Apoptosis and Necrosis , 1997, The Journal of experimental medicine.

[32]  P. W. Hochachka,et al.  Unifying theory of hypoxia tolerance: molecular/metabolic defense and rescue mechanisms for surviving oxygen lack. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[33]  A. Beavis,et al.  The mitochondrial inner membrane anion channel is inhibited by DIDS , 1996, Journal of bioenergetics and biomembranes.

[34]  S. Pietri,et al.  5-(Diethoxyphosphoryl)-5-methyl-1-pyrroline N-oxide: a new efficient phosphorylated nitrone for the in vitro and in vivo spin trapping of oxygen-centered radicals. , 1995, Journal of medicinal chemistry.

[35]  G. Fröschl,et al.  Chromatin condensation during apoptosis is accompanied by degradation of lamin A+B, without enhanced activation of cdc2 kinase , 1994, The Journal of cell biology.

[36]  M. Poznansky,et al.  Electron spin resonance study on the permeability of superoxide radicals in lipid bilayers and biological membranes , 1992, FEBS letters.

[37]  D. Choi,et al.  The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death. , 1990, Annual review of neuroscience.

[38]  J. Eisinger,et al.  Association of cytosol hemoglobin with the membrane in intact erythrocytes. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[39]  E. Flamm,et al.  Free radicals in cerebral ischemia. , 1978, Stroke.