The PAR proteins: fundamental players in animal cell polarization.

[1]  Y. Jan,et al.  Hippocampal Neuronal Polarity Specified by Spatially Localized mPar3/mPar6 and PI 3-Kinase Activity , 2003, Cell.

[2]  T. Pawson,et al.  A mammalian PAR-3–PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity , 2000, Nature Cell Biology.

[3]  Y. Jan,et al.  Drosophila Neuroblast Asymmetric Cell Division: Recent Advances and Implications for Stem Cell Biology , 2006, Neuron.

[4]  Y. Nagai,et al.  PAR‐6 regulates aPKC activity in a novel way and mediates cell‐cell contact‐induced formation of the epithelial junctional complex , 2001, Genes to cells : devoted to molecular & cellular mechanisms.

[5]  C. Waterman-Storer,et al.  Conserved microtubule–actin interactions in cell movement and morphogenesis , 2003, Nature Cell Biology.

[6]  G. Drewes,et al.  MARK, a Novel Family of Protein Kinases That Phosphorylate Microtubule-Associated Proteins and Trigger Microtubule Disruption , 1997, Cell.

[7]  D. Johnston,et al.  Bazooka and PAR-6 are required with PAR-1 for the maintenance of oocyte fate in Drosophila , 2001, Current Biology.

[8]  Y. Jan,et al.  Drosophila par-1 is required for oocyte differentiation and microtubule organization , 2001, Current Biology.

[9]  R. Lin,et al.  MEX-5 and MEX-6 function to establish soma/germline asymmetry in early C. elegans embryos. , 2000, Molecular cell.

[10]  K. Kemphues,et al.  An Atypical PKC Directly Associates and Colocalizes at the Epithelial Tight Junction with ASIP, a Mammalian Homologue of Caenorhabditis elegans Polarity Protein PAR-3 , 1998, The Journal of cell biology.

[11]  Alan Hall,et al.  Rho GTPases Control Polarity, Protrusion, and Adhesion during Cell Movement , 1999, The Journal of cell biology.

[12]  C. Doe,et al.  Par-6 and aPKC are not required for axon or dendrite specification in Drosophila , 2004 .

[13]  A. Hall,et al.  Cdc42 and Par6–PKCζ regulate the spatially localized association of Dlg1 and APC to control cell polarization , 2005, The Journal of cell biology.

[14]  C. Doe,et al.  Drosophila aPKC regulates cell polarity and cell proliferation in neuroblasts and epithelia , 2003, The Journal of cell biology.

[15]  Giovanna Lucchini,et al.  Functional and Physical Interactions between Yeast 14-3-3 Proteins, Acetyltransferases, and Deacetylases in Response to DNA Replication Perturbations , 2007, Molecular and Cellular Biology.

[16]  C. Sardet,et al.  The aPKC–PAR-6–PAR-3 cell polarity complex localizes to the centrosome attracting body, a macroscopic cortical structure responsible for asymmetric divisions in the early ascidian embryo , 2006, Journal of Cell Science.

[17]  J. Labbé,et al.  The forces that position a mitotic spindle asymmetrically are tethered until after the time of spindle assembly , 2004, The Journal of cell biology.

[18]  C. Nüsslein-Volhard,et al.  Mutations affecting segment number and polarity in Drosophila , 1980, Nature.

[19]  N. Perrimon,et al.  Integrated activity of PDZ protein complexes regulates epithelial polarity , 2003, Nature Cell Biology.

[20]  P. Thibault,et al.  aPKC‐mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb , 2007, The EMBO journal.

[21]  T. Hurd,et al.  Pars and polarity: taking control of Rac , 2005, Nature Cell Biology.

[22]  A. Hall,et al.  Cdc42 and noncanonical Wnt signal transduction pathways cooperate to promote cell polarity , 2007, The Journal of cell biology.

[23]  K. Hahn,et al.  Spatiotemporal dynamics of RhoA activity in migrating cells , 2006, Nature.

[24]  I. Macara.  Parsing the Polarity Code , 2004, Nature Reviews Molecular Cell Biology.

[25]  X. Morin,et al.  Analysis of partner of inscuteable, a Novel Player of Drosophila Asymmetric Divisions, Reveals Two Distinct Steps in Inscuteable Apical Localization , 2000, Cell.

[26]  J. Sanes,et al.  LKB1 and SAD Kinases Define a Pathway Required for the Polarization of Cortical Neurons , 2007, Cell.

[27]  J. Ahringer,et al.  Similar requirements for CDC-42 and the PAR-3/PAR-6/PKC-3 complex in diverse cell types. , 2007, Developmental biology.

[28]  J. Shulman,et al.  The role of PAR-1 in regulating the polarised microtubule cytoskeleton in the Drosophila follicular epithelium , 2003, Development.

[29]  S. Mango,et al.  CYK-4/GAP Provides a Localized Cue to Initiate Anteroposterior Polarity upon Fertilization , 2006, Science.

[30]  J. Whittaker.  Acetylcholinesterase development in extra cells caused by changing the distribution of myoplasm in ascidian embryos. , 1980, Journal of embryology and experimental morphology.

[31]  D. St Johnston,et al.  An Oskar-Dependent Positive Feedback Loop Maintains the Polarity of the Drosophila Oocyte , 2007, Current Biology.

[32]  B. Lang,et al.  A Comparative Genomics Approach to the Evolution of Eukaryotes and their Mitochondria 1 , 1999, The Journal of eukaryotic microbiology.

[33]  I. Macara,et al.  Mammalian Pins Is a Conformational Switch that Links NuMA to Heterotrimeric G Proteins , 2004, Cell.

[34]  J. Ahringer,et al.  CDC-42 controls early cell polarity and spindle orientation in C. elegans , 2001, Current Biology.

[35]  F. Motegi,et al.  Sequential functioning of the ECT-2 RhoGEF, RHO-1 and CDC-42 establishes cell polarity in Caenorhabditis elegans embryos , 2006, Nature Cell Biology.

[36]  Yue Zhang,et al.  Regulation of Cell Polarity and Protrusion Formation by Targeting RhoA for Degradation , 2003, Science.

[37]  A. Fukui,et al.  Meiotic maturation induces animal-vegetal asymmetric distribution of aPKC and ASIP/PAR-3 in Xenopus oocytes. , 2000, Development.

[38]  F. Piano,et al.  Atypical protein kinase C cooperates with PAR-3 to establish embryonic polarity in Caenorhabditis elegans. , 1998, Development.

[39]  Yue Zhang,et al.  Regulation of the Polarity Protein Par6 by TGFß Receptors Controls Epithelial Cell Plasticity , 2005, Science.

[40]  Kei Sakamoto,et al.  LKB1-dependent signaling pathways. , 2006, Annual review of biochemistry.

[41]  M. Zwart,et al.  Drosophila Anterior-Posterior Polarity Requires Actin-Dependent PAR-1 Recruitment to the Oocyte Posterior , 2006, Current Biology.

[42]  S. Bowman,et al.  The Drosophila NuMA Homolog Mud regulates spindle orientation in asymmetric cell division. , 2006, Developmental cell.

[43]  H. Horvitz,et al.  Mutations that affect neural cell lineages and cell fates during the development of the nematode Caenorhabditis elegans. , 1983, Cold Spring Harbor symposia on quantitative biology.

[44]  C. Rappleye,et al.  Pod-2, along with pod-1, defines a new class of genes required for polarity in the early Caenorhabditis elegans embryo. , 2001, Developmental Biology.

[45]  G. Joberty,et al.  The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42 , 2000, Nature Cell Biology.

[46]  X. Goff,et al.  An overview of the KIN1/PAR‐1/MARK kinase family , 2004, Biology of the cell.

[47]  A. Suzuki,et al.  Lgl mediates apical domain disassembly by suppressing the PAR-3-aPKC-PAR-6 complex to orient apical membrane polarity , 2006, Journal of Cell Science.

[48]  E. Mandelkow,et al.  Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity. , 2002, Molecular biology of the cell.

[49]  K. Mechtler,et al.  The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl , 2003, Nature.

[50]  L. Collinson,et al.  Regulated and Polarized PtdIns(3,4,5)P3 Accumulation Is Essential for Apical Membrane Morphogenesis in Photoreceptor Epithelial Cells , 2006, Current Biology.

[51]  J. Nance,et al.  PAR proteins and the establishment of cell polarity during C. elegans development , 2005, BioEssays : news and reviews in molecular, cellular and developmental biology.

[52]  Erik Sahai,et al.  Smurf1 regulates tumor cell plasticity and motility through degradation of RhoA leading to localized inhibition of contractility , 2007, The Journal of cell biology.

[53]  J. Knoblich,et al.  Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblasts , 1999, Nature.

[54]  T. Nakamura,et al.  Mechanism and role of localized activation of Rho-family GTPases in growth factor-stimulated fibroblasts and neuronal cells. , 2005, Biochemical Society transactions.

[55]  K. Kemphues,et al.  par-2, a gene required for blastomere asymmetry in Caenorhabditis elegans, encodes zinc-finger and ATP-binding motifs. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[56]  K. Kemphues,et al.  PARsing Embryonic Polarity , 2000, Cell.

[57]  J. Wallingford,et al.  The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity , 2005, Development.

[58]  K. Kemphues,et al.  PAR-2 is asymmetrically distributed and promotes association of P granules and PAR-1 with the cortex in C. elegans embryos. , 1996, Development.

[59]  A. Hyman,et al.  Acto-myosin reorganization and PAR polarity in C. elegans , 2007, Development.

[60]  Pavel Tomancak,et al.  A Drosophila melanogaster homologue of Caenorhabditis elegans par-1 acts at an early step in embryonic-axis formation , 2000, Nature Cell Biology.

[61]  R. Benton,et al.  Drosophila PAR-1 and 14-3-3 Inhibit Bazooka/PAR-3 to Establish Complementary Cortical Domains in Polarized Cells , 2003, Cell.

[62]  J. Priess,et al.  Cortical flows powered by asymmetrical contraction transport PAR proteins to establish and maintain anterior-posterior polarity in the early C. elegans embryo. , 2004, Developmental cell.

[63]  T. Pawson,et al.  A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl , 2003, Nature Cell Biology.

[64]  S. van den Heuvel,et al.  A complex of LIN-5 and GPR proteins regulates G protein signaling and spindle function in C elegans. , 2003, Genes & development.

[65]  A. Schetter,et al.  Polarization of the C. elegans zygote proceeds via distinct establishment and maintenance phases , 2003, Development.

[66]  Anirban Datta,et al.  PTEN-Mediated Apical Segregation of Phosphoinositides Controls Epithelial Morphogenesis through Cdc42 , 2007, Cell.

[67]  K. Kemphues,et al.  par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed , 1995, Cell.

[68]  Hans Clevers,et al.  LKB1 tumor suppressor protein: PARtaker in cell polarity. , 2004, Trends in cell biology.

[69]  A. Ephrussi,et al.  Par-1 regulates stability of the posterior determinant Oskar by phosphorylation , 2002, Nature Cell Biology.

[70]  Y. Jan,et al.  APC and GSK-3β Are Involved in mPar3 Targeting to the Nascent Axon and Establishment of Neuronal Polarity , 2004, Current Biology.

[71]  A. Le Bivic,et al.  CRB3 binds directly to Par6 and regulates the morphogenesis of the tight junctions in mammalian epithelial cells. , 2003, Molecular biology of the cell.

[72]  P. Brennwald,et al.  Mammalian PAR-1 determines epithelial lumen polarity by organizing the microtubule cytoskeleton , 2004, The Journal of cell biology.

[73]  V. Thannickal,et al.  Faculty Opinions recommendation of Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity. , 2005 .

[74]  T. Hurd,et al.  Direct interaction of two polarity complexes implicated in epithelial tight junction assembly , 2003, Nature Cell Biology.

[75]  J. Labbé,et al.  Heterotrimeric G protein signaling functions with dynein to promote spindle positioning in C. elegans , 2007, The Journal of cell biology.

[76]  W. Wood,et al.  Immunofluorescence visualization of germ-line-specific cytoplasmic granules in embryos, larvae, and adults of Caenorhabditis elegans. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[77]  L. Boyd,et al.  Analysis of RING finger genes required for embryogenesis in C. elegans , 2004, Genesis.

[78]  J. Ahringer,et al.  Asymmetrically Distributed C. elegans Homologs of AGS3/PINS Control Spindle Position in the Early Embryo , 2003, Current Biology.

[79]  A. Shevchenko,et al.  A protein complex containing Inscuteable and the Gα-binding protein Pins orients asymmetric cell divisions in Drosophila , 2000, Current Biology.

[80]  Elaine Fuchs,et al.  Asymmetric cell divisions promote stratification and differentiation of mammalian skin , 2005, Nature.

[81]  D. Morton,et al.  The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry. , 2000, Development.

[82]  A. Suzuki,et al.  Mammalian Lgl Forms a Protein Complex with PAR-6 and aPKC Independently of PAR-3 to Regulate Epithelial Cell Polarity , 2003, Current Biology.

[83]  M. Labouesse.  Faculty Opinions recommendation of Sequential functioning of the ECT-2 RhoGEF, RHO-1 and CDC-42 establishes cell polarity in Caenorhabditis elegans embryos. , 2006 .

[84]  J. Priess,et al.  C. elegans PAR-3 and PAR-6 are required for apicobasal asymmetries associated with cell adhesion and gastrulation , 2003, Development.

[85]  N. Papalopulu,et al.  aPKC, Crumbs3 and Lgl2 control apicobasal polarity in early vertebrate development , 2005, Development.

[86]  G. Seydoux,et al.  Stabilization of cell polarity by the C. elegans RING protein PAR-2. , 2006, Developmental cell.

[87]  Joerg Betschinger,et al.  Sequential roles of Cdc42, Par-6, aPKC, and Lgl in the establishment of epithelial polarity during Drosophila embryogenesis. , 2004, Developmental cell.

[88]  E. Munro.  PAR proteins and the cytoskeleton: a marriage of equals. , 2006, Current opinion in cell biology.

[89]  D. Morton,et al.  Identification of genes required for cytoplasmic localization in early C. elegans embryos , 1988, Cell.

[90]  I. Macara,et al.  Par-3 controls tight junction assembly through the Rac exchange factor Tiam1 , 2005, Nature Cell Biology.

[91]  K. Kaibuchi,et al.  Numb controls integrin endocytosis for directional cell migration with aPKC and PAR-3. , 2007, Developmental cell.

[92]  A. Suzuki,et al.  aPKC Acts Upstream of PAR-1b in Both the Establishment and Maintenance of Mammalian Epithelial Polarity , 2004, Current Biology.

[93]  I. Macara,et al.  Structure of Cdc42 in a complex with the GTPase‐binding domain of the cell polarity protein, Par6 , 2003, The EMBO journal.

[94]  J. Labbé,et al.  PAR Proteins Regulate Microtubule Dynamics at the Cell Cortex in C. elegans , 2003, Current Biology.

[95]  S. Strome,et al.  C. elegans PAR Proteins Function by Mobilizing and Stabilizing Asymmetrically Localized Protein Complexes , 2004, Current Biology.

[96]  O. Bossinger,et al.  Molecular and functional analysis of apical junction formation in the gut epithelium of Caenorhabditis elegans. , 2004, Developmental biology.

[97]  Jonathon Howard,et al.  The Distribution of Active Force Generators Controls Mitotic Spindle Position , 2003, Science.

[98]  Yuh Nung Jan,et al.  PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling , 2001, Nature Cell Biology.

[99]  Haigen Huang,et al.  Stimulation of erythropoiesis by inhibiting a new hematopoietic death receptor in transgenic zebrafish , 2000, Nature Cell Biology.

[100]  I. Macara,et al.  A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization , 2001, Nature Cell Biology.

[101]  U. Tepass,et al.  Interactions between the crumbs, lethal giant larvae and bazooka pathways in epithelial polarization , 2003, Nature Cell Biology.

[102]  M. Diaz-Meco,et al.  DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila , 2004, The Journal of cell biology.

[103]  Lesilee S. Rose,et al.  PAR-3 and PAR-1 inhibit LET-99 localization to generate a cortical band important for spindle positioning in Caenorhabditis elegans embryos. , 2007, Molecular biology of the cell.

[104]  Jeremy B. A. Green,et al.  Distinct PAR-1 proteins function in different branches of Wnt signaling during vertebrate development. , 2005, Developmental cell.

[105]  Lesilee S. Rose,et al.  LET-99 determines spindle position and is asymmetrically enriched in response to PAR polarity cues in C. elegans embryos. , 2002, Development.

[106]  H. Piwnica-Worms,et al.  Atypical PKC Phosphorylates PAR-1 Kinases to Regulate Localization and Activity , 2004, Current Biology.

[107]  D. Morton,et al.  The Caenorhabditis elegans par-5 gene encodes a 14-3-3 protein required for cellular asymmetry in the early embryo. , 2002, Developmental biology.

[108]  P. Gönczy,et al.  Coupling of cortical dynein and Gα proteins mediates spindle positioning in Caenorhabditis elegans , 2007, Nature Cell Biology.

[109]  K. Kemphues,et al.  Asymmetrically distributed PAR-3 protein contributes to cell polarity and spindle alignment in early C. elegans embryos , 1995, Cell.

[110]  E. Knust,et al.  Control of spindle orientation in Drosophila by the Par-3-related PDZ-domain protein Bazooka , 1998, Current Biology.

[111]  Pierre Gönczy,et al.  Translation of Polarity Cues into Asymmetric Spindle Positioning in Caenorhabditis elegans Embryos , 2003, Science.

[112]  A. Ephrussi,et al.  Par-1 regulates bicoid mRNA localisation by phosphorylating Exuperantia , 2004, Development.

[113]  Marion Müller-Borg,et al.  Direct association of Bazooka/PAR-3 with the lipid phosphatase PTEN reveals a link between the PAR/aPKC complex and phosphoinositide signaling , 2005, Development.

[114]  E. Nishida,et al.  XGAP, an ArfGAP, is required for polarized localization of PAR proteins and cell polarity in Xenopus gastrulation. , 2006, Developmental cell.

[115]  I. Macara,et al.  The polarity protein PAR-3 and TIAM1 cooperate in dendritic spine morphogenesis , 2006, Nature Cell Biology.

[116]  A. Hall,et al.  Integrin-Mediated Activation of Cdc42 Controls Cell Polarity in Migrating Astrocytes through PKCζ , 2001, Cell.

[117]  J. P. Fawcett,et al.  The Polarity Protein Par-3 Directly Interacts with p75NTR to Regulate Myelination , 2006, Science.

[118]  Jun Hee Lee,et al.  Energy-dependent regulation of cell structure by AMP-activated protein kinase , 2007, Nature.

[119]  Douglas I. Johnson.  Cdc42: An Essential Rho-Type GTPase Controlling Eukaryotic Cell Polarity , 1999, Microbiology and Molecular Biology Reviews.

[120]  J. Borg,et al.  Scrib Controls Cdc42 Localization and Activity to Promote Cell Polarization during Astrocyte Migration , 2006, Current Biology.

[121]  K. Kaibuchi,et al.  Role of the PAR-3–KIF3 complex in the establishment of neuronal polarity , 2004, Nature Cell Biology.

[122]  A. Hyman,et al.  Centrosomes direct cell polarity independently of microtubule assembly in C. elegans embryos , 2004, Nature.

[123]  M. Peifer,et al.  The positioning and segregation of apical cues during epithelial polarity establishment in Drosophila , 2005, The Journal of cell biology.

[124]  M. Vidal,et al.  MEX-3 interacting proteins link cell polarity to asymmetric gene expression in Caenorhabditis elegans. , 2002, Development.

[125]  M. Poo,et al.  LKB1/STRAD Promotes Axon Initiation During Neuronal Polarization , 2007, Cell.

[126]  A. Hyman,et al.  CDC-42 and RHO-1 coordinate acto-myosin contractility and PAR protein localization during polarity establishment in C. elegans embryos , 2006, Development.

[127]  K. Kemphues,et al.  PAR-6 is a conserved PDZ domain-containing protein that colocalizes with PAR-3 in Caenorhabditis elegans embryos. , 1999, Development.

[128]  Richard Benton,et al.  The Drosophila Homolog of C. elegans PAR-1 Organizes the Oocyte Cytoskeleton and Directs oskar mRNA Localization to the Posterior Pole , 2000, Cell.

[129]  C. Doe,et al.  Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6–aPKC , 2007, Journal of Cell Science.

[130]  C. Doe,et al.  The NuMA-related Mud protein binds Pins and regulates spindle orientation in Drosophila neuroblasts , 2006, Nature Cell Biology.

[131]  Markus Affolter,et al.  Signaling to cytoskeletal dynamics during chemotaxis. , 2005, Developmental cell.

[132]  G. Seydoux,et al.  Exclusion of germ plasm proteins from somatic lineages by cullin-dependent degradation , 2003, Nature.

[133]  W. Chia,et al.  Apical Complex Genes Control Mitotic Spindle Geometry and Relative Size of Daughter Cells in Drosophila Neuroblast and pI Asymmetric Divisions , 2003, Cell.

[134]  J. Engel,et al.  Phosphatidylinositol-3,4,5-trisphosphate regulates the formation of the basolateral plasma membrane in epithelial cells , 2006, Nature Cell Biology.

[135]  D. St Johnston,et al.  LKB1 and AMPK maintain epithelial cell polarity under energetic stress , 2007, The Journal of cell biology.

[136]  Tong Wang,et al.  Dishevelled promotes axon differentiation by regulating atypical protein kinase C , 2007, Nature Cell Biology.

[137]  Daniel St Johnston,et al.  A role for Drosophila LKB1 in anterior–posterior axis formation and epithelial polarity , 2003, Nature.

[138]  T. Raabe,et al.  Drosophila Pins-binding protein Mud regulates spindle-polarity coupling and centrosome organization , 2006, Nature Cell Biology.