High-resolution beta imaging probe for radioguided surgery

We report on developments of an intraoperative probe, capable of functioning in real time with high spatial resolution and high sensitivity. This probe combines two novel technologies and is based on an electron multiplying charge coupled device (EMCCD) bonded to a high spatial resolution microcolumnar CsI(Tl) scintillator via a flexible fiberoptic cable. Our data demonstrates that the probe can be used with such beta-emitting radiolabels as 18F, 131I, and 32P. The basic design of the probe and its evaluation using standard clinical phantoms is presented. In addition, the operational data obtained on swine models is included to demonstrate the probe's efficacy in practical procedures.