Effect of lithium on diffusion chamber granulopoiesis.

We studied the effect of lithium on diffusion chamber (DC) granulopoiesis. When DC loaded with bone marrow cells were implanted into the peritoneal cavity of mice previously injected with lithium carbonate, more proliferative and nonproliferative granulocytes were produced as compared to DC implanted into control hosts. The number of DC CFU-c was increased significantly in the lithium-treated group, but there was no difference in the number of DC CFU-s. Levels of DC fluid CSF showed no evident correlation with DC myelopoiesis. These data suggest that a humoral factor other than CSF mediates the action of lithium in DC granulopoiesis, and that lithium's influence on DC hematopoietic stem cell proliferation occurs mainly at the CFU-c level.

[1]  L. Harker,et al.  Lithium enhancement of megakaryocytopoiesis in culture: mediation via accessory marrow cells. , 1983, Blood.

[2]  G. Sokal,et al.  In vivo stimulation and inhibition of granulopoiesis: the effect of an inflammatory reaction on murine diffusion chamber granulopoiesis , 1982, British journal of haematology.

[3]  V. Gallicchio,et al.  Cell kinetics of lithium‐induced granulopoiesis , 1982, Cell and tissue kinetics.

[4]  Gallicchio Vs,et al.  Influence of lithium on proliferation of hematopoietic stem cells. , 1981 .

[5]  V. Gallicchio,et al.  Modulation of murine pluripotential stem cell proliferation in vivo by lithium carbonate. , 1980, Blood.

[6]  L. Levitt,et al.  The effect of lithium on murine hematopoiesis in a liquid culture system. , 1980, The New England journal of medicine.

[7]  P. Quesenberry,et al.  Studies on the Regulation of Diffusion Chamber Granulopoiesis , 1980 .

[8]  P. Greenberg,et al.  Effects of lithium chloride on human and murine marrow myeloid colony formation and colony stimulating activity. , 1980, Advances in experimental medicine and biology.

[9]  A. Cordier,et al.  Murine yolk sac hematopoiesis studied with the diffusion chamber technique. , 1978, Experimental hematology.

[10]  P. Galbraith,et al.  Effect of lithium on granulopoiesis in culture. , 1978, Canadian Medical Association journal.

[11]  W. G. Harker,et al.  Enhancement of colony-stimulating activity production by lithium. , 1977, Blood.

[12]  P. Quesenberry,et al.  Fetal hemopoiesis in diffusion chamber cultures. III. The effect of neutropenia. , 1976, Blood.

[13]  W. Robinson,et al.  Felty's syndrome: Effect of lithium on granulopoiesis , 1976 .

[14]  G. Tisman,et al.  Evidence that Lithium Induces Human Granulocyte Proliferation: Elevated Serum Vitamin B12 Binding Capacity in Vivo and Granulocyte Colony Proliferation in Vitro , 1973, British journal of haematology.

[15]  J. Athens,et al.  Humoral stimulators of granulocyte production. , 1973, Blood.

[16]  W. Tyler,et al.  The effect of neutropenia on myeloid growth and the stem cell in an in vivo culture system. , 1972, Blood.

[17]  A. Morley,et al.  Effect of endotoxin on granulopoiesis and colony-stimulating factor. , 1972, The New England journal of medicine.

[18]  H. B. Benestad.  Formation of granulocytes and macrophages in diffusion chamber cultures of mouse blood leucocytes. , 2009, Scandinavian journal of haematology.

[19]  J. Trentin,et al.  Hemopoietic spleen colony studies. I. Growth and differentiation. , 1967, Developmental biology.

[20]  J. Till,et al.  THE DISTRIBUTION OF COLONY-FORMING CELLS AMONG SPLEEN COLONIES. , 1963, Journal of cellular and comparative physiology.

[21]  J. Till,et al.  A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. , 1961, Radiation research.