Cutting Edge: The T Cell Chemoattractant IFN-Inducible Protein 10 Is Essential in Host Defense Against Viral-Induced Neurologic Disease1

The contribution of the T cell chemoattractant chemokine IFN-inducible protein 10 (IP-10) in host defense following viral infection of the CNS was examined. IP-10 is expressed by astrocytes during acute encephalomyelitis in mouse hepatitis virus-infected mice, and the majority of T lymphocytes infiltrating into the CNS expressed the IP-10 receptor CXCR3. Treatment of mice with anti-IP-10 antisera led to increased mortality and delayed viral clearance from the CNS as compared with control mice. Further, administration of anti-IP-10 led to a >70% reduction (p ≤ 0.001) in CD4+ and CD8+ T lymphocyte infiltration into the CNS, which correlated with decreased (p ≤ 0.01) levels of IFN-γ. These data indicate that IP-10 functions as a sentinel molecule in host defense and is essential in the development of a protective Th1 response against viral infection of the CNS.

[1]  J. Libbey,et al.  Alterations in cytokine but not chemokine mRNA expression during three distinct Theiler’s virus infections , 2000, Journal of Neuroimmunology.

[2]  M. Buchmeier,et al.  A Central Role for CD4+ T Cells and RANTES in Virus-Induced Central Nervous System Inflammation and Demyelination , 2000, Journal of Virology.

[3]  M. Salvadori,et al.  Role for interactions between IP-10/Mig and CXCR3 in proliferative glomerulonephritis. , 1999, Journal of the American Society of Nephrology : JASN.

[4]  D. Adams,et al.  Chemokine and chemokine receptor interactions provide a mechanism for selective T cell recruitment to specific liver compartments within hepatitis C-infected liver. , 1999, Journal of immunology.

[5]  W. Karpus,et al.  Central nervous system chemokine expression during Theiler's virus-induced demyelinating disease. , 1999, Journal of neurovirology.

[6]  M. Burdick,et al.  IFN-gamma-inducible protein-10 attenuates bleomycin-induced pulmonary fibrosis via inhibition of angiogenesis. , 1999, Journal of immunology.

[7]  M. Baggiolini,et al.  Short Communication Increased Expression of IP-10, IL-8, MCP-1, and MCP-3 in Ulcerative Colitis , 1999 .

[8]  M. Buchmeier,et al.  Viral-induced neurodegenerative disease , 1999, Current Opinion in Microbiology.

[9]  H. Weiner,et al.  CCR5(+) and CXCR3(+) T cells are increased in multiple sclerosis and their ligands MIP-1alpha and IP-10 are expressed in demyelinating brain lesions. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[10]  H. Olsen,et al.  Gene expression and production of the monokine induced by IFN-gamma (MIG), IFN-inducible T cell alpha chemoattractant (I-TAC), and IFN-gamma-inducible protein-10 (IP-10) chemokines by human neutrophils. , 1999, Journal of immunology.

[11]  Jakob S. Jensen,et al.  Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients. , 1999, The Journal of clinical investigation.

[12]  Q. Hamid,et al.  The T cell-specific CXC chemokines IP-10, Mig, and I-TAC are expressed by activated human bronchial epithelial cells. , 1999, Journal of immunology.

[13]  N. Sarvetnick,et al.  Islet-specific Th1, but not Th2, cells secrete multiple chemokines and promote rapid induction of autoimmune diabetes. , 1999, Journal of immunology.

[14]  D. Hinton,et al.  IFN-γ Is Required for Viral Clearance from Central Nervous System Oligodendroglia , 1999, The Journal of Immunology.

[15]  G. Karupiah,et al.  The Interferon-Inducible Chemokines MuMig and Crg-2 Exhibit Antiviral Activity In Vivo , 1999, Journal of Virology.

[16]  H. Pfister,et al.  Identification of a T cell chemotactic factor in the cerebrospinal fluid of HIV-1-infected individuals as interferon-γ inducible protein 10 , 1999, Journal of Neuroimmunology.

[17]  I. Campbell,et al.  Chemokines and the inflammatory response to viral infection in the central nervous system with a focus on lymphocytic choriomeningitis virus. , 1999, Journal of neurovirology.

[18]  C. Brosnan,et al.  Differential chemokine induction by the mouse adenovirus type-1 in the central nervous system of susceptible and resistant strains of mice. , 1999, Journal of neurovirology.

[19]  E. Bröcker,et al.  Chemokines IL-8, GROalpha, MCP-1, IP-10, and Mig are sequentially and differentially expressed during phase-specific infiltration of leukocyte subsets in human wound healing. , 1998, The American journal of pathology.

[20]  J. Finke,et al.  The CXC chemokines IP-10 and Mig are necessary for IL-12-mediated regression of the mouse RENCA tumor. , 1998, Journal of immunology.

[21]  R. Cardiff,et al.  Delayed wound healing and disorganized neovascularization in transgenic mice expressing the IP-10 chemokine. , 1998, Proceedings of the Association of American Physicians.

[22]  C. Mackay,et al.  The chemokine receptor CXCR3 mediates rapid and shear‐resistant adhesion‐induction of effector T lymphocytes by the chemokines IP10 and Mig , 1998, European journal of immunology.

[23]  A. Luster,et al.  Chemokines--chemotactic cytokines that mediate inflammation. , 1998, The New England journal of medicine.

[24]  M. Buchmeier,et al.  Dynamic regulation of alpha- and beta-chemokine expression in the central nervous system during mouse hepatitis virus-induced demyelinating disease. , 1998, Journal of immunology.

[25]  D. Taub,et al.  CD8+ myelin peptide-specific T cells can chemoattract CD4+ myelin peptide-specific T cells: importance of IFN-inducible protein 10. , 1998, Journal of immunology.

[26]  C. Mackay,et al.  The chemokine receptor CXCR3 mediates rapid and shear‐resistant adhesion‐induction of effector T lymphocytes by the chemokines IP10 and Mig , 1998, European journal of immunology.

[27]  J. Farber.  Chemokines, lymphocytes, and HIV. , 1998, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

[28]  I. Campbell,et al.  Chemokine gene expression in the brains of mice with lymphocytic choriomeningitis , 1997, Journal of virology.

[29]  Y. Tominaga,et al.  Expression of IFN-inducible protein-10 in chronic hepatitis. , 1997, Journal of immunology.

[30]  J. Farber.  Mig and IP‐10: CXC chemokines that target lymphocytes , 1997, Journal of leukocyte biology.

[31]  M. Buchmeier,et al.  Disassociation between the in vitro and in vivo effects of nitric oxide on a neurotropic murine coronavirus , 1997, Journal of virology.

[32]  D. Dormont,et al.  Chemoattractant factors (IP‐10, MIP‐1α, IL‐16) mRNA expression in mononuclear cells from different tissues during acute SIVmac251 infection of macaques , 1997, Journal of medical primatology.

[33]  R. Ransohoff,et al.  Synchronous synthesis of alpha- and beta-chemokines by cells of diverse lineage in the central nervous system of mice with relapses of chronic experimental autoimmune encephalomyelitis. , 1997, The American journal of pathology.

[34]  A. Luster,et al.  Regulated production of the interferon‐γ‐inducible protein−10 (IP‐10) chemokine by human neutrophils , 1997 .

[35]  Simon A. Jones,et al.  Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes , 1996, The Journal of experimental medicine.

[36]  J. Fleming,et al.  Pathogenesis of mouse hepatitis virus-induced demyelination. , 1996, Journal of neurovirology.

[37]  D. Cook.  Requirement of MIP-1α for an inflammatory response to viral infection , 1995 .

[38]  J. Sheridan,et al.  Requirement of MIP-1 alpha for an inflammatory response to viral infection. , 1995, Science.

[39]  Y. Ohmori,et al.  The interferon-stimulated response element and a kappa B site mediate synergistic induction of murine IP-10 gene transcription by IFN-gamma and TNF-alpha. , 1995, Journal of immunology.

[40]  M. Buchmeier,et al.  Cytokine induction during T-cell-mediated clearance of mouse hepatitis virus from neurons in vivo , 1994, Journal of virology.

[41]  R. Ransohoff,et al.  Astrocyte expression of mRNA encoding cytokines IP‐10 and JE/MCP‐1 in experimental autoimmune encephalomyelitis , 1993, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[42]  Y. Ohmori,et al.  Cooperative interaction between interferon (IFN) stimulus response element and kappa B sequence motifs controls IFN gamma- and lipopolysaccharide-stimulated transcription from the murine IP-10 promoter. , 1993, Journal of Biological Chemistry.

[43]  M. Stoler,et al.  Tissue‐specific expression of murine IP‐10 mRNA following systemic treatment with interferon γ , 1992 .

[44]  J. Farber,et al.  A collection of mRNA species that are inducible in the RAW 264.7 mouse macrophage cell line by gamma interferon and other agents , 1992, Molecular and cellular biology.

[45]  K. Yamaguchi,et al.  Production of mice from a lethal coronavirus infection in the central nervous system by adoptive transfer of virus-specific T cell clones , 1991, Journal of Neuroimmunology.

[46]  S. Stohlman,et al.  Effective clearance of mouse hepatitis virus from the central nervous system requires both CD4+ and CD8+ T cells , 1990, Journal of virology.

[47]  J. Farber.  A macrophage mRNA selectively induced by gamma-interferon encodes a member of the platelet factor 4 family of cytokines. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[48]  J. Ravetch,et al.  Biochemical characterization of a gamma interferon-inducible cytokine (IP-10) , 1987, The Journal of experimental medicine.

[49]  M. Buchmeier,et al.  Site-specific alteration of murine hepatitis virus type 4 peplomer glycoprotein E2 results in reduced neurovirulence , 1986, Journal of virology.

[50]  Andrew D. Luster,et al.  γ-Interferon transcriptionally regulates an early-response gene containing homology to platelet proteins , 1985, Nature.