Maintenance of Th1 hepatitis C virus (HCV)‐specific responses in individuals with acute HCV who achieve sustained virological clearance after treatment

T‐cell responses against hepatitis C are believed to be critical in achieving both natural and treatment‐induced clearance. However, rapid clearance of antigen with early treatment of primary infection may result in reduced or poorly sustained cellular immunity. This study longitudinally examined Th1 and Th2 hepatitis C virus (HCV)‐specific cytokine production and T‐cell effector function from subjects enrolled in the Australian Trial in Acute Hepatitis C comparing three groups: treatment‐induced clearance (sustained virological response [SVR]), treatment non‐response, and untreated spontaneous clearance.

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