The integration of photoacoustic imaging and high intensity focused ultrasound

We have developed an integrated photoacoustic imaging (PAI) and high intensity focused ultrasound (HIFU) system for solid tumor treatment. A single-element, spherically focused ultrasonic transducer, with a central frequency of 5MHz, was used to generate a HIFU field in soft tissue. The same ultrasonic transducer was also used as a detector during photoacoustic imaging before and after HIFU treatments. During each experiment, targeted soft tissue was first imaged by PAI. The resulted image was used for the planning of subsequent HIFU treatment. After HIFU treatment, the sample was imaged again by PAI to evaluate the treatment result. Good contrast was obtained between photoacoustic images before and after HIFU treatment. It is concluded that PA imaging technology may potentially be combined with HIFU treatment for imaging-guided therapy.

[1]  Xu Xiao.  Photoacoustic imaging in biomedicine , 2008 .

[2]  Geng Ku,et al.  Deeply penetrating photoacoustic tomography in biological tissues enhanced with an optical contrast agent. , 2005, Optics letters.

[3]  Wang Hong,et al.  HIGH INTENSITY FOCUSED ULTRASOUND FOR TUMOR TREATMENT , 2000 .

[4]  Michael C. Kolios,et al.  Assessment of opto-mechanical behavior of biological samples by interferometry , 2009, BiOS.

[5]  J. Kennedy.  High-intensity focused ultrasound in the treatment of solid tumours , 2005, Nature Reviews Cancer.

[6]  F. Gleeson,et al.  High-intensity focused ultrasound for the treatment of liver tumours. , 2004, Ultrasonics.

[7]  Lihong V. Wang,et al.  Deep reflection-mode photoacoustic imaging of biological tissue. , 2007, Journal of biomedical optics.

[8]  F A Jolesz,et al.  MR imaging-guided focused ultrasound surgery of fibroadenomas in the breast: a feasibility study. , 2001, Radiology.

[9]  R A Kruger,et al.  Thermoacoustic computed tomography--technical considerations. , 1999, Medical physics.

[10]  R. Kruger,et al.  Photoacoustic ultrasound (PAUS)--reconstruction tomography. , 1995, Medical physics.

[11]  Lihong V. Wang,et al.  Prospects of photoacoustic tomography. , 2008, Medical physics.

[12]  K. Hynynen.  MRI-guided focused ultrasound treatments. , 2010, Ultrasonics.

[13]  Lihong V. Wang,et al.  In vivo dark-field reflection-mode photoacoustic microscopy. , 2005, Optics letters.

[14]  Mathias Fink,et al.  Photoacoustic guidance of high intensity focused ultrasound with selective optical contrasts and time-reversal , 2009 .

[15]  Kullervo Hynynen,et al.  MR imaging-guided focused ultrasound surgery of uterine leiomyomas: a feasibility study. , 2003, Radiology.

[16]  Oleg A. Sapozhnikov,et al.  Opto-acoustic diagnostics of the thermal action of high-intensity focused ultrasound on biological tissues: the possibility of its applications and model experiments , 2006 .

[17]  J. Rewcastle,et al.  High Intensity Focused Ultrasound for Prostate Cancer: A Review of the Scientific Foundation, Technology and Clinical Outcomes , 2006, Technology in cancer research & treatment.

[18]  R. Esenaliev,et al.  Sensitivity of laser opto-acoustic imaging in detection of small deeply embedded tumors , 1999 .

[19]  Kleanthis Ioannides,et al.  In vitro and in vivo brain ablation created by high-intensity focused ultrasound and monitored by MRI , 2009, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[20]  Kirill V. Larin,et al.  Monitoring of tissue coagulation during thermotherapy using optoacoustic technique , 2005 .

[21]  F. D. de Mul,et al.  Three-dimensional photoacoustic imaging of blood vessels in tissue. , 1998, Optics letters.