HepSEQ: International Public Health Repository for Hepatitis B

HepSEQ is a repository for an extensive library of public health and molecular data relating to hepatitis B virus (HBV) infection collected from international sources. It is hosted by the Centre for Infections, Health Protection Agency (HPA), England, United Kingdom. This repository has been developed as a web-enabled, quality-controlled database to act as a tool for surveillance, HBV case management and for research. The web front-end for the database system can be accessed from . The format of the database system allows for comprehensive molecular, clinical and epidemiological data to be deposited into a functional database, to search and manipulate the stored data and to extract and visualize the information on epidemiological, virological, clinical, nucleotide sequence and mutational aspects of HBV infection through web front-end. Specific tools, built into the database, can be utilized to analyse deposited data and provide information on HBV genotype, identify mutations with known clinical significance (e.g. vaccine escape, precore and antiviral-resistant mutations) and carry out sequence homology searches against other deposited strains. Further mechanisms are also in place to allow specific tailored searches of the database to be undertaken.

[1]  S. Günther.  Genetic variation in HBV infection: genotypes and mutants. , 2006, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.

[2]  J. Maynard.  Hepatitis B: global importance and need for control. , 1990, Vaccine.

[3]  C E Stevens,et al.  The e antigen and vertical transmission of hepatitis B surface antigen. , 1977, American journal of epidemiology.

[4]  A. Couroucé,et al.  Molecular basis of hepatitis B virus serotype variations within the four major subtypes. , 1992, The Journal of general virology.

[5]  S. Löfdahl,et al.  Comparison of the amino acid sequences of nine different serotypes of hepatitis B surface antigen and genomic classification of the corresponding hepatitis B virus strains. , 1992, The Journal of general virology.

[6]  I. Mushahwar,et al.  Genetic relatedness of hepatitis B viral strains of diverse geographical origin and natural variations in the primary structure of the surface antigen. , 1993, The Journal of general virology.

[7]  A. Kidd,et al.  Genetic variability in hepatitis B viruses. , 2002, The Journal of general virology.

[8]  M S Waterman,et al.  Identification of common molecular subsequences. , 1981, Journal of molecular biology.

[9]  F. Chisari,et al.  Hepatitis B virus immunopathogenesis. , 1995, Annual review of immunology.

[10]  M. Roggendorf.  Current topics in hepatitis. , 2004, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.

[11]  E. Myers,et al.  Basic local alignment search tool. , 1990, Journal of molecular biology.

[12]  F. Zoulim.  In vitro models for studying hepatitis B virus drug resistance. , 2006, Seminars in liver disease.

[13]  Christus,et al.  A General Method Applicable to the Search for Similarities in the Amino Acid Sequence of Two Proteins , 2022 .

[14]  Man-Fung Yuen,et al.  Viral hepatitis B , 2003, The Lancet.

[15]  F. Zoulim,et al.  Resistance of human hepatitis B virus to reverse transcriptase inhibitors: from genotypic to phenotypic testing. , 2005, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.

[16]  G. Siegl.  [Hepatitis A virus infection. A review]. , 2003, Praxis.

[17]  G. Missale,et al.  Immunopathogenesis of hepatitis B. , 2003, Journal of hepatology.

[18]  F. Mahoney,et al.  Update on Diagnosis, Management, and Prevention of Hepatitis B Virus Infection , 1999, Clinical Microbiology Reviews.

[19]  P. van Damme,et al.  Mutant hepatitis B viruses: a matter of academic interest only or a problem with far-reaching implications? , 2001, Vaccine.

[20]  P. Coursaget,et al.  Genetic Diversity of Hepatitis B Virus Strains Derived Worldwide: Genotypes, Subgenotypes, and HBsAg Subtypes , 2004, Intervirology.

[21]  Paul Kellam,et al.  Genotyping Hepatitis B virus from whole- and sub-genomic fragments using position-specific scoring matrices in HBV STAR. , 2006, The Journal of general virology.

[22]  M. Kane.  Global status of hepatitis B immunisation , 1996, The Lancet.

[23]  J. Zuckerman,et al.  Current topics in hepatitis B. , 2000, The Journal of infection.