Brain activation patterns during memory of cognitive agency

Agency is the awareness that one's own self is the agent or author of an action, a thought, or a feeling. The implicit memory that one's self was the originator of a cognitive event - the sense of cognitive agency - has not yet been fully explored in terms of relevant neural systems. In this functional magnetic resonance imaging (fMRI) study, we examined brain activation patterns differentiating memory for the source of previously self-generated vs. experimenter-presented word items from a sentence completion paradigm designed to be emotionally neutral and semantically constrained in content. Accurate memory for the source of self-generated vs. externally-presented word items resulted in activation of dorsal medial prefrontal cortex (mPFC) bilaterally, supporting an emerging body of work that indicates a key role for this region in self-referential processing. Our data extend the function of mPFC into the domain of memory and the accurate retrieval of the sense of cognitive agency under conditions where agency was encoded implicitly.

[1]  M. Raichle,et al.  Neural correlates of self-induced dysphoria. , 1993, The American journal of psychiatry.

[2]  Paul C. Fletcher,et al.  Anterior prefrontal cortex and the recollection of contextual information , 2005, Neuropsychologia.

[3]  Anthony D Wagner,et al.  Executive Control during Episodic Retrieval Multiple Prefrontal Processes Subserve Source Memory , 2002, Neuron.

[4]  C. Frith,et al.  Movement and Mind: A Functional Imaging Study of Perception and Interpretation of Complex Intentional Movement Patterns , 2000, NeuroImage.

[5]  G. Winocur,et al.  In Search of the Self: A Positron Emission Tomography Study , 1999 .

[6]  G. Shulman,et al.  Medial prefrontal cortex and self-referential mental activity: Relation to a default mode of brain function , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[7]  Sophia Vinogradov,et al.  Reduced Self-Referential Source Memory Performance is Associated with Interpersonal Dysfunction in Borderline Personality Disorder. , 2006, Journal of personality disorders.

[8]  T. Shallice,et al.  Right prefrontal cortex and episodic memory retrieval: a functional MRI test of the monitoring hypothesis. , 1999, Brain : a journal of neurology.

[9]  Marcia K. Johnson,et al.  Left prefrontal activation during episodic remembering: an event‐related fMRI study , 1998, Neuroreport.

[10]  C. N. Macrae,et al.  Finding the Self? An Event-Related fMRI Study , 2002, Journal of Cognitive Neuroscience.

[11]  Philip McGuire,et al.  Brain activity during stimulus independent thought. , 1996 .

[12]  G L Shulman,et al.  INAUGURAL ARTICLE by a Recently Elected Academy Member:A default mode of brain function , 2001 .

[13]  F. Craik,et al.  In search of the emotional self: an fMRI study using positive and negative emotional words. , 2003, The American journal of psychiatry.

[14]  M. Torrens.  Co-Planar Stereotaxic Atlas of the Human Brain—3-Dimensional Proportional System: An Approach to Cerebral Imaging, J. Talairach, P. Tournoux. Georg Thieme Verlag, New York (1988), 122 pp., 130 figs. DM 268 , 1990 .

[15]  Pierre Maquet,et al.  Brain activity underlying encoding and retrieval of source memory. , 2002, Cerebral cortex.

[16]  E. Auerbach,et al.  Relative Shift in Activity from Medial to Lateral Frontal Cortex During Internally Versus Externally Guided Word Generation , 2001, Journal of Cognitive Neuroscience.

[17]  A. Yonelinas.  The Nature of Recollection and Familiarity: A Review of 30 Years of Research , 2002 .

[18]  C D Frith,et al.  The functional roles of prefrontal cortex in episodic memory. II. Retrieval. , 1998, Brain : a journal of neurology.

[19]  Michael D. Rugg,et al.  The Role of the Prefrontal Cortex in Recognition Memory and Memory for Source: An fMRI Study , 1999, NeuroImage.

[20]  Cheryl L. Grady,et al.  Distributed self in episodic memory: neural correlates of successful retrieval of self-encoded positive and negative personality traits , 2004, NeuroImage.

[21]  D. Rubin,et al.  Brain Activity during Episodic Retrieval of Autobiographical and Laboratory Events: An fMRI Study using a Novel Photo Paradigm , 2004, Journal of Cognitive Neuroscience.

[22]  Marcia K. Johnson,et al.  Left Anterior Prefrontal Activation Increases with Demands to Recall Specific Perceptual Information , 2000, The Journal of Neuroscience.

[23]  G. Fink,et al.  Neural activation during selective attention to subjective emotional responses , 1997, Neuroreport.

[24]  Jin Fan,et al.  Functional magnetic resonance imaging of source versus item memory , 2003, Neuroreport.

[25]  Sterling C. Johnson,et al.  Neural correlates of self-reflection. , 2002, Brain : a journal of neurology.

[26]  Kenichi Ohki,et al.  The role of the parahippocampal gyrus in source memory for external and internal events , 2002, Neuroreport.

[27]  Evelyn C. Ferstl,et al.  The Anterior Frontomedian Cortex and Evaluative Judgment: An fMRI Study , 2002, NeuroImage.

[28]  Adrian M Owen,et al.  Distinct roles for lateral and medial anterior prefrontal cortex in contextual recollection. , 2005, Journal of neurophysiology.

[29]  Jesper Andersson,et al.  Isolating the retrieval of imagined pictures during episodic memory: activation of the left precuneus and left prefrontal cortex , 2003, NeuroImage.

[30]  Jane F. Banfield,et al.  Medial prefrontal activity predicts memory for self. , 2004, Cerebral cortex.

[31]  Carol A. Seger,et al.  Cortical Activations during judgments about the self and an other person , 2004, Neuropsychologia.

[32]  Anthony D Wagner,et al.  Memory orientation and success: separable neurocognitive components underlying episodic recognition , 2003, Neuropsychologia.

[33]  J. Desmond,et al.  Prefrontal cortex and recognition memory. Functional-MRI evidence for context-dependent retrieval processes. , 1998, Brain : a journal of neurology.

[34]  Perrine Ruby,et al.  A relation between rest and the self in the brain? , 2003, Brain Research Reviews.

[35]  J. Hart,et al.  Distinct prefrontal cortex activity associated with item memory and source memory for visual shapes. , 2003, Brain research. Cognitive brain research.

[36]  B. Ober,et al.  Clinical and neurocognitive aspects of source monitoring errors in schizophrenia. , 1997, The American journal of psychiatry.

[37]  Blair T. Johnson,et al.  The self-reference effect in memory: a meta-analysis. , 1997, Psychological bulletin.

[38]  Karl J. Friston,et al.  Neuroanatomical correlates of externally and internally generated human emotion. , 1997, The American journal of psychiatry.