Intervertebral disk calcification of the spine in an elderly population: radiographic prevalence, location, and distribution and correlation with spinal degeneration.

PURPOSE To determine the prevalence, distribution, and location of intervertebral disk calcification (IDC) in the thoracic and lumbar spine and the association of IDC with radiographically evident spinal degenerative changes in cadavers. MATERIALS AND METHODS Anterior vertebral columns comprising T1 through L5 were removed from 223 cadavers (183 men, 40 women; mean age at death, 67 years; range, 37-94 years). Approximately 5-mm-thick parasagittal sections were investigated with high-contrast radiography. The presence of IDC, osteophytes, vertebral endplate abnormalities, and vacuum phenomena was recorded, and the height of disk space was measured at 3,568 intervertebral levels. Logistic regression analysis was performed. RESULTS IDC was identified in 178 (80%) of the 223 cadavers. Of 3,568 disks, 459 (13%) had IDC, and 289 cases (63%) were located in the annulus fibrosus. IDC was most common in the lower thoracic spine, occurring in 275 (60%) of 459 disks. IDC occurred in 159 (87%) of 183 men and 19 (48%) of 40 women. Logistic regression analysis was adjusted for age, and results showed that the frequency of IDC was significantly higher in men in upper, middle, and lower segments of the thoracic spine (P <.05) but not in the lumbar spine (P =.09). IDC correlated with increasing age (P <.001) and disk space loss (P <.001) at all spinal levels. There was no association of IDC with vacuum phenomena or vertebral endplate abnormalities at any spinal level. CONCLUSION IDC is common in elderly persons, especially in the annulus fibrosus and lower thoracic spine. The prevalence of IDC increases with age and extent of disk space loss.

[1]  K. Singer,et al.  Influence of age and gender on thoracic vertebral body shape and disc degeneration: an MR investigation of 169 cases , 2000, Journal of anatomy.

[2]  D. Resnick,et al.  Radiographic and pathologic features of spinal involvement in diffuse idiopathic skeletal hyperostosis (DISH). , 1976, Radiology.

[3]  O. Boachie-Adjei,et al.  The distribution of calcific deposits in intervertebral discs of the lumbosacral spine. , 1990, Clinical orthopaedics and related research.

[4]  Lindsay J. Rowe,et al.  Degenerative Diseases of the Vertebral Column , 1985, Radiology.

[5]  L. Twomey,et al.  Age changes in the bone density and structure of the lumbar vertebral column. , 1983, Journal of anatomy.

[6]  L T Twomey,et al.  Age changes in lumbar vertebrae and intervertebral discs. , 1987, Clinical orthopaedics and related research.

[7]  A. Baert,et al.  Radiological prevalence of lumbar intervertebral disc calcification in the elderly: an autopsy study , 1996, Skeletal Radiology.

[8]  R. Williams,et al.  The spine in idiopathic haemochromatosis. , 1971, Annals of the rheumatic diseases.

[9]  A. Weinberger,et al.  Intervertebral disc calcification in adults: a review. , 1978, Seminars in arthritis and rheumatism.

[10]  N. Fazzalari,et al.  Intervertebral disc disorganisation and its relationship to age adjusted vertebral body morphometry and vertebral bone architecture , 2001, The Anatomical record.

[11]  C. Chou Pathological studies on calcification of the intervertebral discs. , 1982, Nihon Seikeigeka Gakkai zasshi.