Long-term renal function in kidney donors: a comparison of donors and their siblings.

To assess the effects of unilateral nephrectomy, we evaluated renal function and hypertension in kidney donors who had had nephrectomies 10 years ago or more and siblings who had not had nephrectomies. No statistically significant difference was found between the prevalence of hypertension in donors and siblings. Serum creatinine concentrations were 20% higher in donors and creatinine clearances, 20% lower than corresponding values in siblings. Twenty-four-hour urinary protein excretion increased in all donors after nephrectomy and was more marked in men than women. Of the 38 donors, 12 excreted more than 150 mg/24 h of urinary protein, but only 2 excreted more than 300 mg/24 h. The presence of proteinuria did not correlate with the presence of hypertension, level of renal function, or time since nephrectomy. We conclude that, with the exception of mild proteinuria of unknown clinical significance, unilateral nephrectomy is not associated with adverse effects on kidney function.

[1]  M. Suthanthiran,et al.  Impact of renal donation. Long-term clinical and biochemical follow-up of living donors in a single center. , 1985, The American journal of medicine.

[2]  P. Robitaille,et al.  LONG-TERM FOLLOW-UP OF PATIENTS WHO UNDERWENT UNILATERAL NEPHRECTOMY IN CHILDHOOD , 1985, The Lancet.

[3]  C. F. Anderson,et al.  The risks of unilateral nephrectomy: status of kidney donors 10 to 20 years postoperatively. , 1985, Mayo Clinic proceedings.

[4]  L. Hunsicker,et al.  Urinary albumin excretion after donor nephrectomy. , 1985, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[5]  B. Brenner,et al.  Hypertension and proteinuria: long-term sequelae of uninephrectomy in humans. , 1984, Kidney international.

[6]  O. Salvatierra,et al.  Long-term renal function in kidney donors. Sustained compensatory hyperfiltration with no adverse effects. , 1983, Transplantation.

[7]  B. Brenner,et al.  Dietary protein intake and the progressive nature of kidney disease: the role of hemodynamically mediated glomerular injury in the pathogenesis of progressive glomerular sclerosis in aging, renal ablation, and intrinsic renal disease. , 1982, The New England journal of medicine.

[8]  B. Brenner,et al.  Hyperfiltration in remnant nephrons: a potentially adverse response to renal ablation. , 1981, The American journal of physiology.

[9]  M Feinleib,et al.  Recommendations for human blood pressure determination by sphygmomanometers. Subcommittee of the AHA Postgraduate Education Committee. , 1980, Circulation.

[10]  C. Sing,et al.  Familial aggregation of blood pressure and weight in adoptive families. I. Comparisons of blood pressure and weight statistics among families with adopted, natural, or both natural and adopted children. , 1979, American journal of epidemiology.

[11]  W. Kannel,et al.  Blood pressure aggregation in families. , 1979, American journal of epidemiology.

[12]  P. Biron,et al.  Familial aggregation of blood pressure and its components. , 1978, Pediatric clinics of North America.

[13]  R. Freeman,et al.  Renal function before and after unilateral nephrectomy in renal donors. , 1975, Kidney international.

[14]  E. Leumann,et al.  Early responses of glomerular filtration rate to unilateral nephrectomy. , 1974, Kidney international.

[15]  R. Rieselbach,et al.  Factors influencing the increase in glomerular filtration rate in the remaining kidney of transplant donors. , 1973, The American journal of medicine.

[16]  E. Glasgow,et al.  The familial nephrotic syndrome. II. A clinicopathological study. , 1973, Clinical nephrology.

[17]  H. Husdan,et al.  Estimation of creatinine by the Jaffe reaction. A comparison of three methods. , 1968, Clinical chemistry.

[18]  D. Ogden.  Donor and recipient function 2 to 4 years after renal homotransplantation. A paired study of 28 cases. , 1967, Annals of internal medicine.

[19]  D. D. Bois,et al.  CLINICAL CALORIMETRY: TENTH PAPER A FORMULA TO ESTIMATE THE APPROXIMATE SURFACE AREA IF HEIGHT AND WEIGHT BE KNOWN , 1916 .

[20]  B. Chavers,et al.  Information on 628 living-related kidney donors at a single institution, with long-term follow-up in 472 cases , 1984 .

[21]  Cockcroft Dw,et al.  Prediction of Creatinine Clearance from Serum Creatinine , 1976 .

[22]  J. B. Hansen,et al.  Survival after nephrectomy. , 1968, Scandinavian journal of urology and nephrology.