Proteasome inhibition enhances AAV-mediated transgene expression in human synoviocytes in vitro and in vivo.

[1]  N. Muzyczka,et al.  Adenovirus-Facilitated Nuclear Translocation of Adeno-Associated Virus Type 2 , 2002, Journal of Virology.

[2]  J. Engelhardt,et al.  Ubiquitination of both Adeno-Associated Virus Type 2 and 5 Capsid Proteins Affects the Transduction Efficiency of Recombinant Vectors , 2002, Journal of Virology.

[3]  O. Danos,et al.  Intracellular Trafficking of Adeno-Associated Virus Vectors: Routing to the Late Endosomal Compartment and Proteasome Degradation , 2001, Journal of Virology.

[4]  H. Hsu,et al.  Adeno-associated virus production of soluble tumor necrosis factor receptor neutralizes tumor necrosis factor alpha and reduces arthritis. , 2000, Human gene therapy.

[5]  M. Mezzina,et al.  Adeno-associated virus-mediated delivery of IL-4 prevents collagen-induced arthritis , 2000, Gene Therapy.

[6]  G. Boivin,et al.  Adeno-associated virus mediates long-term gene transfer and delivery of chondroprotective IL-4 to murine synovium. , 2000, Molecular therapy : the journal of the American Society of Gene Therapy.

[7]  D. Duan,et al.  Endosomal processing limits gene transfer to polarized airway epithelia by adeno-associated virus. , 2000, The Journal of clinical investigation.

[8]  P. Elliott,et al.  Proteasome Inhibition: a New Strategy in Cancer Treatment , 2000, Investigational New Drugs.

[9]  E. Giannini,et al.  Viral IL-10 and Soluble TNF Receptor Act Synergistically to Inhibit Collagen-Induced Arthritis Following Adenovirus- Mediated Gene Transfer1 , 2000, The Journal of Immunology.

[10]  Arun Srivastava,et al.  Impaired Intracellular Trafficking of Adeno-Associated Virus Type 2 Vectors Limits Efficient Transduction of Murine Fibroblasts , 2000, Journal of Virology.

[11]  Thomas Pap,et al.  Activation of synovial fibroblasts in rheumatoid arthritis: lack of expression of the tumour suppressor PTEN at sites of invasive growth and destruction , 1999, Arthritis research.

[12]  E. Lechman,et al.  Direct adenoviral gene transfer of viral IL-10 to rabbit knees with experimental arthritis ameliorates disease in both injected and contralateral control knees. , 1999, Journal of immunology.

[13]  P. Robbins,et al.  Adenoviral transfer of the viral IL-10 gene periarticularly to mouse paws suppresses development of collagen-induced arthritis in both injected and uninjected paws. , 1999, Journal of immunology.

[14]  R. Chen,et al.  Adeno-associated virus-mediated gene transfer to the brain: duration and modulation of expression. , 1999, Human gene therapy.

[15]  P. Elliott,et al.  Role of the proteasome and NF-kappaB in streptococcal cell wall-induced polyarthritis. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[16]  James M. Wilson,et al.  Adeno-Associated Virus as a Vector for Liver-Directed Gene Therapy , 1998, Journal of Virology.

[17]  James M. Wilson,et al.  High-titer adeno-associated viral vectors from a Rep/Cap cell line and hybrid shuttle virus. , 1998, Human gene therapy.

[18]  A. Goldberg,et al.  Proteasome inhibitors: valuable new tools for cell biologists. , 1998, Trends in cell biology.

[19]  G. Boivin,et al.  Inhibition of collagen-induced arthritis in mice by viral IL-10 gene transfer. , 1998, Journal of immunology.

[20]  C. Jorgensen,et al.  Adenovirus-mediated transfer of viral IL-10 gene inhibits murine collagen-induced arthritis. , 1998, Journal of immunology.

[21]  E. Lechman,et al.  Direct adenovirus-mediated gene transfer of interleukin 1 and tumor necrosis factor alpha soluble receptors to rabbit knees with experimental arthritis has local and distal anti-arthritic effects. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[22]  L. Turka,et al.  Amelioration of collagen-induced arthritis by CD95 (Apo-1/Fas)-ligand gene transfer. , 1997, The Journal of clinical investigation.

[23]  D. Green,et al.  Somatic mutations in the p53 tumor suppressor gene in rheumatoid arthritis synovium. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[24]  W. Hauswirth,et al.  Efficient photoreceptor-targeted gene expression in vivo by recombinant adeno-associated virus. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[25]  Juan Li,et al.  Gene Transfer by Adeno-Associated Virus Vectors into the Central Nervous System , 1997, Experimental Neurology.

[26]  James M. Wilson,et al.  Recombinant adeno-associated virus for muscle directed gene therapy , 1997, Nature Medicine.

[27]  M. Kaplitt,et al.  Defective viral vectors as agents for gene transfer in the nervous system , 1997, Journal of Neuroscience Methods.

[28]  J. Wilson,et al.  Biology of adenovirus vectors with E1 and E4 deletions for liver-directed gene therapy , 1996, Journal of virology.

[29]  J. Wilson,et al.  A novel adenovirus-adeno-associated virus hybrid vector that displays efficient rescue and delivery of the AAV genome. , 1996, Human gene therapy.

[30]  R. Samulski,et al.  Efficient long-term gene transfer into muscle tissue of immunocompetent mice by adeno-associated virus vector , 1996, Journal of virology.

[31]  G. Breese,et al.  Differential and persistent expression patterns of CNS gene transfer by an adeno-associated virus (AAV) vector , 1996, Brain Research.

[32]  G. Boivin,et al.  Anti-T cell receptor monoclonal antibody prolongs transgene expression following adenovirus-mediated in vivo gene transfer to mouse synovium. , 1996, Human gene therapy.

[33]  R F Standaert,et al.  Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin , 1995, Science.

[34]  R. Strieter,et al.  Cytokines in Rheumatoid Arthritis , 1998, Drugs & aging.

[35]  A. Goldberg,et al.  Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules , 1994, Cell.

[36]  G. Firestein,et al.  Pannus and pannocytes , 1994 .

[37]  M. Feldmann,et al.  TNF alpha--a pivotal role in rheumatoid arthritis? , 1992, British journal of rheumatology.

[38]  T. Mosmann,et al.  Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI. , 1990, Science.

[39]  B. Henderson,et al.  Synovial lining cell hyperplasia in rheumatoid arthritis: dogma and fact. , 1988, Annals of the rheumatic diseases.

[40]  P. L. Deininger,et al.  DNA sequence and expression of the B95-8 Epstein—Barr virus genome , 1984, Nature.

[41]  B. Henderson,et al.  DNA synthesis in human rheumatoid and nonrheumatoid synovial lining. , 1980, Annals of the rheumatic diseases.

[42]  F. Graham,et al.  Characteristics of a human cell line transformed by DNA from human adenovirus type 5. , 1977, The Journal of general virology.

[43]  A. van der Eb,et al.  A new technique for the assay of infectivity of human adenovirus 5 DNA. , 1973, Virology.

[44]  P. Mapp,et al.  Proliferative activity of cells in the synovium as demonstrated by a monoclonal antibody, Ki67 , 2004, Rheumatology International.

[45]  G. Firestein.  Somatic mutation in the tumore suppressor gene in erosive rheumatoid arthritis synovium , 1997 .

[46]  D. Rubin,et al.  The proteasome : a protein-degrading organelle ? , 2022 .