Idiopathic recurrent myoglobinuria and persistent weakness

The case of an adolescent with idiopathic recurrent myoglobinuria is reported. The following features are emphasized: (1) persistence of limb weakness and elevated CK levels between the attacks, (2) a constant myopathic pattern in EMG, and (3) chronic morphologic abnormalities of myopathy in two muscle biopsies. All known causes of myoglobinuria were investigated and ruled out.

[1]  F. Jennekens,et al.  Carnitine palmitoyltransferase II deficiency with normal carnitine palmitoyltransferase I in skeletal muscle and leucocytes , 1979, Journal of the Neurological Sciences.

[2]  C. Norden,et al.  Infectious mononucleosis associated with rhabdomyolysis and renal failure. , 1978, Southern medical journal.

[3]  J. Schlesinger,et al.  Myoglobinuria associated with herpes-group viral infections. , 1978, Archives of internal medicine.

[4]  D. Morens,et al.  Rhabdomyolysis associated with influenza A , 1977 .

[5]  M. A. Demos,et al.  Acute exertional rhabdomyolysis. , 1974, Archives of internal medicine.

[6]  S. Dimauro,et al.  Muscle Carnitine Palmityltransferase Deficiency and Myoglobinuria , 1973, Science.

[7]  T. Tanaka,et al.  PHOSPHOFRUCTOKINASE DEFICIENCY IN SKELETAL MUSCLE. A NEW TYPE OF GLYCOGENOSIS. , 1965, Biochemical and biophysical research communications.

[8]  L. Larsson,et al.  Hereditary metabolic myopathy with paroxysmal myoglobinuria due to abnormal glycolysis1 , 1964, Journal of neurology, neurosurgery, and psychiatry.

[9]  J. Korein,et al.  The clinical syndrome of paroxysmal paralytic myoglobinuria , 1959, Neurology.

[10]  Oliver H. Lowry,et al.  Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.

[11]  B. McArdle.  MYOPATHY DUE TO A DEFECT IN MUSCLE GLYCOGEN BREAKDOWN , 1951, Clinical science.

[12]  S. Dimauro,et al.  Phosphoglycerate kinase deficiency: a new cause of recurrent myoglobinuria. , 1981, Transactions of the American Neurological Association.

[13]  H. Hers,et al.  [89] Enzymes of glycogen degradation in biopsy material , 1966 .