Drug effects on ventilatory control and upper airway physiology related to sleep apnea

[1]  M. Bonora,et al.  Differential elevation by protriptyline and depression by diazepam of upper airway respiratory motor activity. , 2015, The American review of respiratory disease.

[2]  A. Malhotra,et al.  Defining phenotypic causes of obstructive sleep apnea. Identification of novel therapeutic targets. , 2013, American journal of respiratory and critical care medicine.

[3]  J. Dempsey,et al.  Effects of stabilizing or increasing respiratory motor outputs on obstructive sleep apnea. , 2013, Journal of applied physiology.

[4]  C. Hoyos,et al.  The effects of testosterone on ventilatory responses in men with obstructive sleep apnea: a randomised, placebo‐controlled trial , 2013, Journal of sleep research.

[5]  E. Welsh,et al.  Drug therapy for obstructive sleep apnoea in adults. , 2013, The Cochrane database of systematic reviews.

[6]  H. Ruetten,et al.  Sensitization of upper airway mechanoreceptors as a new pharmacologic principle to treat obstructive sleep apnea: investigations with AVE0118 in anesthetized pigs. , 2013, Sleep.

[7]  D. Hillman.  A new pharmacological treatment to treat obstructive sleep apnea? , 2013, Sleep.

[8]  G. Marks,et al.  Health outcomes of continuous positive airway pressure versus oral appliance treatment for obstructive sleep apnea: a randomized controlled trial. , 2013, American journal of respiratory and critical care medicine.

[9]  D. White,et al.  Obstructive sleep apnea pharmacotherapy: one step closer. , 2013, American journal of respiratory and critical care medicine.

[10]  S. Hughes,et al.  Identification of the mechanism mediating genioglossus muscle suppression in REM sleep. , 2013, American journal of respiratory and critical care medicine.

[11]  A. Somogyi,et al.  The effects of a single mild dose of morphine on chemoreflexes and breathing in obstructive sleep apnea , 2013, Respiratory Physiology & Neurobiology.

[12]  M. Badr,et al.  Effects of clonidine on breathing during sleep and susceptibility to central apnoea , 2013, Respiratory Physiology & Neurobiology.

[13]  C. Guilleminault,et al.  Pharmacotherapy of obstructive sleep apnea , 2012, Expert opinion on pharmacotherapy.

[14]  B. Kayser,et al.  Effects of acetazolamide on cerebrovascular function and breathing stability at 5050 m , 2012, The Journal of physiology.

[15]  C. Guilleminault,et al.  Beneficial effect of donepezil on obstructive sleep apnea: a double-blind, placebo-controlled clinical trial. , 2012, Sleep medicine.

[16]  B. Edwards,et al.  Acetazolamide improves loop gain but not the other physiological traits causing obstructive sleep apnoea , 2012, The Journal of physiology.

[17]  Ronald R Grunstein,et al.  Phenotyping interindividual variability in obstructive sleep apnoea response to temazepam using ventilatory chemoreflexes during wakefulness , 2011, Journal of sleep research.

[18]  J. Duffin,et al.  Measuring the respiratory chemoreflexes in humans , 2011, Respiratory Physiology & Neurobiology.

[19]  James Duffin,et al.  The role of the central chemoreceptors: A modeling perspective , 2010, Respiratory Physiology & Neurobiology.

[20]  J. Herdegen,et al.  Prospective trial of efficacy and safety of ondansetron and fluoxetine in patients with obstructive sleep apnea syndrome. , 2010, Sleep.

[21]  P. Haouzi,et al.  The hypoxia-induced facilitation of augmented breaths is suppressed by the common effect of carbonic anhydrase inhibition , 2010, Respiratory Physiology & Neurobiology.

[22]  K. Strohl.  Drug trials for obstructive sleep apnea. , 2010, Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine.

[23]  P. Ainslie,et al.  Exacerbation of obstructive sleep apnea by oral indomethacin. , 2010, Chest.

[24]  D. Jensen,et al.  Variability of the ventilatory response to Duffin's modified hyperoxic and hypoxic rebreathing procedure in healthy awake humans , 2010, Respiratory Physiology & Neurobiology.

[25]  M. Badr,et al.  Effect of episodic hypoxia on the susceptibility to hypocapnic central apnea during NREM sleep. , 2010, Journal of applied physiology.

[26]  J. Greer,et al.  Opiate-Induced Suppression of Rat Hypoglossal Motoneuron Activity and Its Reversal by Ampakine Therapy , 2010, PloS one.

[27]  Dorothy S. Lee,et al.  Progressive augmentation and ventilatory long‐term facilitation are enhanced in sleep apnoea patients and are mitigated by antioxidant administration , 2009, The Journal of physiology.

[28]  R. Horner,et al.  Opioid receptor mechanisms at the hypoglossal motor pool and effects on tongue muscle activity in vivo , 2009, The Journal of physiology.

[29]  M. Joyner,et al.  Effects of indomethacin on cerebrovascular response to hypercapnea and hypocapnea in breath-hold diving and obstructive sleep apnea , 2009, Respiratory Physiology & Neurobiology.

[30]  J. Duffin,et al.  Integration of cerebrovascular CO2 reactivity and chemoreflex control of breathing: mechanisms of regulation, measurement, and interpretation. , 2009, American journal of physiology. Regulatory, integrative and comparative physiology.

[31]  J. Stradling,et al.  Pharmacological approaches to the treatment of obstructive sleep apnoea , 2009, Expert opinion on investigational drugs.

[32]  J. Dempsey,et al.  Influence of cerebral blood flow on breathing stability. , 2009, Journal of applied physiology.

[33]  M. Hirshkowitz,et al.  Review: Pharmacotherapy of obstructive sleep apnea , 2008, Therapeutic advances in respiratory disease.

[34]  M. Younes,et al.  Role of respiratory control mechanisms in the pathogenesis of obstructive sleep disorders. , 2008, Journal of applied physiology.

[35]  F. Chung,et al.  A Systemic Review of Obstructive Sleep Apnea and Its Implications for Anesthesiologists , 2008, Anesthesia and analgesia.

[36]  A. Malhotra,et al.  Effect of oxygen in obstructive sleep apnea: Role of loop gain , 2008, Respiratory Physiology & Neurobiology.

[37]  Anup V. Desai,et al.  Two randomized placebo-controlled trials to evaluate the efficacy and tolerability of mirtazapine for the treatment of obstructive sleep apnea. , 2008, Sleep.

[38]  Ronald R Grunstein,et al.  Adherence to continuous positive airway pressure therapy: the challenge to effective treatment. , 2008, Proceedings of the American Thoracic Society.

[39]  J. Hedner,et al.  Pharmacological treatment of sleep apnea: current situation and future strategies. , 2008, Sleep medicine reviews.

[40]  J. Dempsey,et al.  Chronic intermittent hypoxia increases the CO2 reserve in sleeping dogs. , 2007, Journal of applied physiology.

[41]  G. Mitchell,et al.  Is there a link between intermittent hypoxia‐induced respiratory plasticity and obstructive sleep apnoea? , 2007, Experimental physiology.

[42]  D. White.  Pathogenesis of obstructive and central sleep apnea. , 2005, American journal of respiratory and critical care medicine.

[43]  L. Kubin,et al.  REM sleep-like atonia of hypoglossal (XII) motoneurons is caused by loss of noradrenergic and serotonergic inputs. , 2005, American journal of respiratory and critical care medicine.

[44]  O. Drummer,et al.  Central sleep apnea in stable methadone maintenance treatment patients. , 2005, Chest.

[45]  J. Duffin,et al.  Overnight changes of chemoreflex control in obstructive sleep apnoea patients , 2005, Respiratory Physiology & Neurobiology.

[46]  J. Dempsey.  Crossing the apnoeic threshold: causes and consequences , 2005, Experimental physiology.

[47]  J. Rowley,et al.  Treatment with leuprolide acetate decreases the threshold of the ventilatory response to carbon dioxide in healthy males , 2004, The Journal of physiology.

[48]  A. Malhotra,et al.  Ventilatory control and airway anatomy in obstructive sleep apnea. , 2004, American journal of respiratory and critical care medicine.

[49]  J. Dempsey,et al.  The ventilatory responsiveness to CO2 below eupnoea as a determinant of ventilatory stability in sleep , 2004, The Journal of physiology.

[50]  J. Hedner,et al.  Reduction of sleep-disordered breathing after physostigmine. , 2003, American journal of respiratory and critical care medicine.

[51]  J. Stradling,et al.  Effect of ondansetron on moderate obstructive sleep apnoea, a single night, placebo‐controlled trial , 2003, Journal of sleep research.

[52]  S. Veasey,et al.  Hypoglossal nerve response to 5-HT3 drugs injected into the XII nucleus and vena cava in the rat. , 2001, Sleep.

[53]  J. Duffin,et al.  Repeated hypoxic exposures change respiratory chemoreflex control in humans , 2001, The Journal of physiology.

[54]  U. Magalang,et al.  Serotonergic modulation of ventilation and upper airway stability in obese Zucker rats. , 2001, American journal of respiratory and critical care medicine.

[55]  J. Hendricks,et al.  The effects of ondansetron on sleep-disordered breathing in the English bulldog. , 2001, Sleep.

[56]  J. Sunderram,et al.  Serotonergic stimulation of the genioglossus and the response to nasal continuous positive airway pressure. , 2000, American journal of respiratory and critical care medicine.

[57]  D. Carley,et al.  Mirtazapine, a mixed-profile serotonin agonist/antagonist, suppresses sleep apnea in the rat. , 1999, American journal of respiratory and critical care medicine.

[58]  R. Berry,et al.  Acute effects of paroxetine on genioglossus activity in obstructive sleep apnea. , 1999, Sleep.

[59]  J. Hedner,et al.  Effect of serotonin uptake inhibition on breathing during sleep and daytime symptoms in obstructive sleep apnea. , 1999, Sleep.

[60]  I. Marc,et al.  Effects of naloxone on upper airway collapsibility in normal sleeping subjects. , 1996, Thorax.

[61]  P. Cistulli,et al.  Effect of short-term hormone replacement in the treatment of obstructive sleep apnoea in postmenopausal women. , 1994, Thorax.

[62]  E. Bancalari,et al.  Comparison of the effects of acetazolamide and aminophylline on apnea incidence and on ventilatory response to CO2, in preterm infants , 1994, Pediatric pulmonology.

[63]  David Handelsman,et al.  Androgen blockade does not affect sleep-disordered breathing or chemosensitivity in men with obstructive sleep apnea. , 1992, The American review of respiratory disease.

[64]  G. Pillar,et al.  Amelioration of sleep apnea by salicylate-induced hyperventilation. , 1992, The American review of respiratory disease.

[65]  D. Hudgel,et al.  Response of obstructive sleep apnea to fluoxetine and protriptyline. , 1991, Chest.

[66]  H. Kimura,et al.  Progesterone therapy for sleep apnea syndrome evaluated by occlusion pressure responses to exogenous loading. , 1989, The American review of respiratory disease.

[67]  H. Kimura,et al.  Obese patients with sleep apnea syndrome treated by progesterone. , 1988, The Tohoku journal of experimental medicine.

[68]  C. Shapiro,et al.  Role of protriptyline and acetazolamide in the sleep apnea/hypopnea syndrome. , 1988, Sleep.

[69]  H. Kimura,et al.  Effects of acetazolamide in patients with the sleep apnoea syndrome. , 1988, Thorax.

[70]  W. Mills,et al.  Respiratory stimulants and sleep periodic breathing at high altitude. Almitrine versus acetazolamide. , 1987, The American review of respiratory disease.

[71]  D. White,et al.  Effects of oral narcotics on sleep-disordered breathing in healthy adults. , 1987, Chest.

[72]  N. Saunders,et al.  Breathing during sleep: the responses to asphyxia and prochlorperazine in normal subjects and patients with obstructive sleep apnea. , 1983, Australian and New Zealand journal of medicine.

[73]  C. Guilleminault,et al.  Naloxone, theophylline, bromocriptine, and obstructive sleep apnea. Negative results. , 1983, Bulletin europeen de physiopathologie respiratoire.

[74]  J. Dempsey,et al.  Mechanisms of hypoxia‐induced periodic breathing during sleep in humans. , 1983, The Journal of physiology.

[75]  M. Kryger,et al.  Protriptyline in obstructive sleep apnea: a double-blind trial. , 1982, The New England journal of medicine.

[76]  L. Findley,et al.  Central Sleep Apnea: Improvement With Acetazolamide Therapy , 1982 .

[77]  T. Roth,et al.  Protriptyline in the treatment of sleep apnoea. , 1982, Thorax.

[78]  F. Plum.  Handbook of Physiology. , 1960 .

[79]  J. Mateika,et al.  The impact of arousal state, sex, and sleep apnea on the magnitude of progressive augmentation and ventilatory long-term facilitation. , 2013, Journal of applied physiology.

[80]  G. Marks,et al.  Health Outcomes of CPAP versus Oral Appliance Treatment for Obstructive Sleep Apnea: A Randomised Controlled Trial , 2013 .

[81]  Dorothy S. Lee,et al.  The hypoxic ventilatory response and ventilatory long-term facilitation are altered by time of day and repeated daily exposure to intermittent hypoxia. , 2011, Journal of applied physiology.

[82]  V. Fencl.  Acid-Base Balance in Cerebral Fluids , 2011 .

[83]  J. Dempsey,et al.  Pathophysiology of sleep apnea. , 2010, Physiological reviews.

[84]  A. Malhotra,et al.  Mechanisms of apnea. , 2009, Progress in cardiovascular diseases.

[85]  C. Olopade,et al.  Efficacy of mirtazapine in obstructive sleep apnea syndrome. , 2007, Sleep.

[86]  J. Rowley,et al.  The determinants of the apnea threshold during NREM sleep in normal subjects. , 2006, Sleep.

[87]  R. Berry,et al.  Low-dose mirtazapine increases genioglossus activity in the anesthetized rat. , 2005, Sleep.

[88]  J. Rowley,et al.  Effect of testosterone on the apneic threshold in women during NREM sleep. , 2003, Journal of applied physiology.

[89]  T. Roth,et al.  A double-blind trial of protriptyline in the treatment of sleep apnea syndrome. , 1988, Henry Ford Hospital medical journal.

[90]  Sergei P. Sorokin.  The Respiratory System , 1983 .

[91]  Corresponding Author and Requests for Reprints: , 2022 .