Alfred P. Sloan Jr. Award. The epidermal growth factor (EGF)

This review summarizes briefly some of the historical aspects of the discovery, isolation, and mode of action of epidermal growth factor (EGF). Also considered are some of the key experiments which relate the biochemical mechanisms of EGF action to the mechanism involved in oncogenic transformation by the retroviruses.

[1]  S. Cohen,et al.  Purification and characterization of epidermal growth factor receptor/protein kinase from normal mouse liver. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[2]  J. Stephenson,et al.  Transformation induced by Abelson murine leukemia virus involves production of a polypeptide growth factor. , 1982, Science.

[3]  J. V. Staros,et al.  Affinity labeling of the protein kinase associated with the epidermal growth factor receptor in membrane vesicles from A431 cells. , 1982, The Journal of biological chemistry.

[4]  E. Krebs,et al.  Epidermal growth factor stimulates the phosphorylation of synthetic tyrosine-containing peptides by A431 cell membranes. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[5]  Michael Chinkers,et al.  A native 170,000 epidermal growth factor receptor-kinase complex from shed plasma membrane vesicles. , 1982, The Journal of biological chemistry.

[6]  C. Heldin,et al.  Stimulation of tyrosine-specific phosphorylation by platelet-derived growth factor , 1982, Nature.

[7]  H. Earp,et al.  Alteration of epidermal growth factor-dependent phosphorylation during rat liver regeneration. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[8]  Y. Yarden,et al.  Monoclonal antibodies against receptor for epidermal growth factor induce early and delayed effects of epidermal growth factor. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[9]  T. Hunter,et al.  Similarities and differences between the effects of epidermal growth factor and Rous sarcoma virus , 1981, The Journal of cell biology.

[10]  J. A. Fernandez-Pol.  Rapid and specific enhancement of phosphorylation of two normal rat kidney cell membrane polypeptides of Mr = 170,000 and 150,000 by epidermal growth factor in vitro. , 1981, The Journal of biological chemistry.

[11]  Jonathan A. Cooper,et al.  Epidermal growth factor induces rapid tyrosine phosphorylation of proteins in A431 human tumor cells , 1981, Cell.

[12]  J. Buss,et al.  Anti-pp60src antibodies are substrates for EGF-stimulated protein kinase , 1981, Nature.

[13]  Michael Chinkers,et al.  Purified EGF receptor–kinase interacts specifically with antibodies to Rous sarcoma virus transforming protein , 1981, Nature.

[14]  S. Cohen,et al.  Identification of phosphotyrosine as a product of epidermal growth factor-activated protein kinase in A-431 cell membranes. , 1980, The Journal of biological chemistry.

[15]  G. Carpenter,et al.  Epidermal growth factor-receptor-protein kinase interactions. Co-purification of receptor and epidermal growth factor-enhanced phosphorylation activity. , 1980, The Journal of biological chemistry.

[16]  G. Carpenter,et al.  Characterization by electrophoresis of epidermal growth factor stimulated phosphorylation using A-431 membranes. , 1980, Biochemistry.

[17]  G. Carpenter,et al.  Rapid enhancement of protein phosphorylation in A-431 cell membrane preparations by epidermal growth factor. , 1979, The Journal of biological chemistry.

[18]  C. F. Fox,et al.  Molecular mechanism of mitogen action: processing of receptor induced by epidermal growth factor. , 1978, Proceedings of the National Academy of Sciences of the United States of America.

[19]  G. Carpenter,et al.  125I-labeled human epidermal growth factor. Binding, internalization, and degradation in human fibroblasts , 1976, The Journal of cell biology.

[20]  S. Cohen,et al.  Epidermal growth factor: identification of a new hormone in human urine. , 1975, Science.

[21]  H. Gregory.  Isolation and structure of urogastrone and its relationship to epidermal growth factor , 1975, Nature.

[22]  G. Carpenter,et al.  Characterization of the binding of 125-I-labeled epidermal growth factor to human fibroblasts. , 1975, The Journal of biological chemistry.

[23]  P. Cuatrecasas,et al.  Insulin and epidermal growth factor. Human fibroblast receptors related to deoxyribonucleic acid synthesis and amino acid uptake. , 1975, The Journal of biological chemistry.

[24]  G. Carpenter,et al.  Human epidermal growth factor: isolation and chemical and biological properties. , 1975, Proceedings of the National Academy of Sciences of the United States of America.

[25]  P. Cuatrecasas,et al.  Epidermal growth factor. Characteristics of specific binding in membranes from liver, placenta, and other target tissues. , 1974, Archives of biochemistry and biophysics.

[26]  S. Cohen,et al.  Epidermal growth factor. Location of disulfide bonds. , 1973, The Journal of biological chemistry.

[27]  S. Cohen,et al.  Epidermal growth factor and a new derivative. Rapid isolation procedures and biological and chemical characterization. , 1972, The Journal of biological chemistry.

[28]  S. Cohen,et al.  The primary structure of epidermal growth factor. , 1972, The Journal of biological chemistry.

[29]  S. Cohen,et al.  Epidermal growth factor , 1972, The Journal of investigative dermatology.

[30]  S. Cohen,et al.  The stimulation of epidermal proliferation by a specific protein (EGF). , 1965, Developmental biology.

[31]  S. Cohen,et al.  Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal. , 1962, The Journal of biological chemistry.

[32]  Stanley N Cohen,et al.  EGF: Receptor Interactions and the Stimulation of Cell Growth , 1981 .

[33]  G. Carpenter,et al.  Epidermal growth factor-receptor-protein kinase interactions. , 1981, Progress in clinical and biological research.

[34]  M. Hollenberg.  Epidermal growth factor-urogastrone, a polypeptide acquiring hormonal status. , 1979, Vitamins and hormones.

[35]  S. Cohen,et al.  The stimulation of epidermal keratinization by a protein isolated from the submaxillary gland of the mouse. , 1963, The Journal of investigative dermatology.