Inhibitory Effect of Different Antibiotics on Nosocomial Pathogen Serratia Marcescens

The S. marcescens has recognized as causes of many hospital epidemics and a causative agent of hospitalized nosocomial infection. It causes secondary infections such as urinary, respiratory, wound and septic arthritis, peritonitis and sinusitis. S. marcescens constitutively possesses chromosomally encoded, inducible Ampc β-lactamases and may acquire plasmid- mediated extended-spectrum β-lactamases (ESBLs). They have ability to develop resistance to many β-lactame antiobiotics. In this studies totally 222 S. marcescens isolate were used for testing antibiotic sensitivity against antibiotic like Ampicillin, Gentamicin, Cefotaxime, Chloramphenicol, Amikacin, Aztreonam, Ceftazidime, Cephalothin, and Ciprofloxacin. The antibiotic sensitivity were analysed in the presence of zone of inhibition around the antibiotic disc. All 222 strains of S. marcescens gave maximum susceptible (13mm) to ciprofloxacin antibiotic and also S. marcescens gave different resistant spectrum to the other 8 antibiotics. Ciprofloxacin is an effective antibiotic for S. marcescens infections.