Gestational cadmium exposure disrupts fetal liver development via repressing estrogen biosynthesis in placental trophoblasts.

[1]  Min-Sun Kim,et al.  Cadmium, lead, and mercury mixtures interact with non-alcoholic fatty liver diseases. , 2022, Environmental pollution.

[2]  Hua Wang,et al.  Environmental cadmium exposure during gestation impairs fetal brain and cognitive function of adult offspring via reducing placental-derived E2 level. , 2022, Chemosphere.

[3]  E. Albrecht,et al.  Estrogen promotes fetal skeletal muscle myofiber development important for insulin sensitivity in offspring , 2022, Endocrine.

[4]  Jun Wang,et al.  Cadmium in Cereal Crops: Uptake and Transport Mechanisms and Minimizing Strategies. , 2022, Journal of agricultural and food chemistry.

[5]  Xiangyu Xu,et al.  [Non-carcinogenic Risk Assessment of Cadmium Exposure Through Drinking Water in Chinese Residents Based on Age-stratification Weight]. , 2022, Huan jing ke xue= Huanjing kexue.

[6]  Rui Feng,et al.  Cadmium induces testosterone synthesis disorder by testicular cell damage via TLR4/MAPK/NF-κB signaling pathway leading to reduced sexual behavior in piglets. , 2022, Ecotoxicology and environmental safety.

[7]  A. Gu,et al.  Association between urinary cadmium concentrations and liver function in adolescents , 2022, Environmental Science and Pollution Research.

[8]  Meie Wang,et al.  Mitigating cadmium contamination of rice soils supporting tobacco-rice rotation in southern China: Win-win or lose-lose? , 2021, Journal of hazardous materials.

[9]  Chao Gu,et al.  Metabolomics Analysis Discovers Estrogen Altering Cell Proliferation via the Pentose Phosphate Pathway in Infertility Patient Endometria , 2021, Frontiers in Endocrinology.

[10]  S. Belcher,et al.  Gestational Cd Exposure in the CD-1 Mouse Sex-Specifically Disrupts Essential Metal Ion Homeostasis , 2021, bioRxiv.

[11]  Liang-Jun Yan,et al.  Cadmium-Induced Kidney Injury: Oxidative Damage as a Unifying Mechanism , 2021, Biomolecules.

[12]  M. Fang,et al.  A review of environmental metabolism disrupting chemicals and effect biomarkers associating disease risks: Where exposomics meets metabolomics. , 2021, Environment international.

[13]  Hua Wang,et al.  Gestational exposure to environmental cadmium induces placental apoptosis and fetal growth restriction via Parkin-modulated MCL-1 degradation. , 2021, Journal of hazardous materials.

[14]  C. Dong,et al.  Oestradiol promotes the intrahepatic bile duct development of C57BL/6CrSlc mice during embryonic period via Notch signalling pathway , 2021, Journal of cellular and molecular medicine.

[15]  Z. Cai,et al.  Long-term environmental cadmium exposure induced serum metabolic changes related to renal and liver dysfunctions in a female cohort from Southwest China. , 2021, The Science of the total environment.

[16]  Weihong Chen,et al.  Systemic inflammation mediates the association of heavy metal exposures with liver injury: A study in general Chinese urban adults. , 2021, Journal of hazardous materials.

[17]  A. Valle,et al.  Sex differences in NAFLD: estrogen influence on the liver-adipose tissue crosstalk. , 2021, Antioxidants & redox signaling.

[18]  Hua Wang,et al.  Environmental cadmium exposure during pregnancy causes diabetes-like phenotypes in mouse offspring: Association with oxidative stress in the fetal liver. , 2021, The Science of the total environment.

[19]  Sudhir Kumar,et al.  Developmental toxicity of cadmium in infants and children: a review , 2021, Environmental analysis, health and toxicology.

[20]  Hua Wang,et al.  Melatonin protects against environmental stress-induced fetal growth restriction via suppressing ROS-mediated GCN2/ATF4/BNIP3-dependent mitophagy in placental trophoblasts. , 2021, Redox biology.

[21]  D. Hardy,et al.  Developmental Origins of Metabolic Disease. , 2020, Physiological reviews.

[22]  S. Belcher,et al.  Gestational Cd Exposure in the CD-1 Mouse Induces Sex-Specific Hepatic Insulin Insensitivity, Obesity, and Metabolic Syndrome in Adult Female Offspring. , 2020, Toxicological sciences : an official journal of the Society of Toxicology.

[23]  C. He,et al.  Oral exposure of pregnant rats to copper nanoparticles caused nutritional imbalance and liver dysfunction in fetus. , 2020, Ecotoxicology and environmental safety.

[24]  Hua Wang,et al.  Environmental exposure to cadmium impairs fetal growth and placental angiogenesis via GCN-2-mediated mitochondrial stress. , 2020, Journal of hazardous materials.

[25]  M. Westwood,et al.  Tracking placental development in health and disease , 2020, Nature Reviews Endocrinology.

[26]  C. Zhang,et al.  Cadmium down-regulates 11β-HSD2 expression and elevates active glucocorticoid level via PERK/p-eIF2α pathway in placental trophoblasts. , 2020, Chemosphere.

[27]  W. Goessling,et al.  Estrogen Acts Through Estrogen Receptor 2b to Regulate Hepatobiliary Fate During Vertebrate Development , 2020, Hepatology.

[28]  S. Fitzpatrick,et al.  Cadmium: Mitigation strategies to reduce dietary exposure , 2020, Journal of food science.

[29]  Yu-Jie Feng,et al.  Maternal cadmium exposure during late pregnancy causes fetal growth restriction via inhibiting placental progesterone synthesis. , 2020, Ecotoxicology and environmental safety.

[30]  D. Bernhard,et al.  Chemical imaging and assessment of cadmium distribution in the human body. , 2019, Metallomics : integrated biometal science.

[31]  S. Xi,et al.  The effects of heavy metals on human metabolism , 2019, Toxicology mechanisms and methods.

[32]  Xu-xiang Zhang,et al.  Effects of chronic cadmium exposure at food limitation-relevant levels on energy metabolism in mice. , 2019, Journal of hazardous materials.

[33]  D. Mellström,et al.  Smoking‐Induced Risk of Osteoporosis Is Partly Mediated by Cadmium From Tobacco Smoke: The MrOS Sweden Study , 2019, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[34]  R. Luo,et al.  The active nuclear form of SREBP1 amplifies ER stress and autophagy via regulation of PERK , 2019, The FEBS journal.

[35]  S. Belcher,et al.  Maternal cadmium exposure in the mouse leads to increased heart weight at birth and programs susceptibility to hypertension in adulthood , 2019, Scientific Reports.

[36]  T. Pichler,et al.  Cadmium in soils and groundwater: A review. , 2019, Applied geochemistry : journal of the International Association of Geochemistry and Cosmochemistry.

[37]  H. Handa,et al.  Estradiol accelerates liver regeneration through estrogen receptor α , 2019, Clinical and experimental gastroenterology.

[38]  A. El Feki,et al.  Effects of estrogen deficiency on liver function and uterine development: assessments of Medicago sativa's activities as estrogenic, anti-lipidemic, and antioxidant agents using an ovariectomized mouse model , 2019, Archives of physiology and biochemistry.

[39]  S. Hooper,et al.  The science of steroids. , 2019, Seminars in fetal & neonatal medicine.

[40]  A. Odermatt,et al.  Subcellular localization and membrane topology of 17β-hydroxysteroid dehydrogenases , 2019, Molecular and Cellular Endocrinology.

[41]  B. Alexander,et al.  Chronic Estrogen Supplementation Prevents the Increase in Blood Pressure in Female Intrauterine Growth-Restricted Offspring at 12 Months of Age , 2019, Hypertension.

[42]  M. Karagas,et al.  Placental metal concentrations in relation to placental growth, efficiency and birth weight. , 2019, Environment international.

[43]  L. Zon,et al.  Estrogen Activation of G-Protein-Coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-Kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes. , 2019, Gastroenterology.

[44]  M. Hiramoto,et al.  Estrogen induces estrogen receptor α expression and hepatocyte proliferation in late pregnancy. , 2019, Biochemical and biophysical research communications.

[45]  J. Arnaud,et al.  Impact of maternal low-level cadmium exposure on glucose and lipid metabolism of the litter at different ages after weaning. , 2019, Chemosphere.

[46]  A. Halhali,et al.  Steroid hormones and pregnancy , 2019, Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.

[47]  Junze Liu,et al.  Effects of glyphosate on the ovarian function of pregnant mice, the secretion of hormones and the sex ratio of their fetuses. , 2018, Environmental pollution.

[48]  F. Lemaigre,et al.  Development of the liver: Insights into organ and tissue morphogenesis. , 2018, Journal of hepatology.

[49]  Wei-Chung Cheng,et al.  Estrogen receptors orchestrate cell growth and differentiation to facilitate liver regeneration , 2018, Theranostics.

[50]  M. Eghbali,et al.  The protective role of estrogen and estrogen receptors in cardiovascular disease and the controversial use of estrogen therapy , 2017, Biology of Sex Differences.

[51]  Adrian J. Green,et al.  Cadmium Exposure Increases the Risk of Juvenile Obesity: A Human and Zebrafish Comparative Study , 2017, bioRxiv.

[52]  N. Tanimizu,et al.  Epithelial Morphogenesis during Liver Development. , 2017, Cold Spring Harbor perspectives in biology.

[53]  Yulong Ma,et al.  The effects of various estrogen doses on the proliferation and differentiation of cultured neural stem cells. , 2016, General physiology and biophysics.

[54]  Shu Tao,et al.  The Challenges and Solutions for Cadmium-contaminated Rice in China: A Critical Review. , 2016, Environment international.

[55]  C. Goursaud,et al.  Evolution of steroids during pregnancy: Maternal, placental and fetal synthesis. , 2016, Annales d'endocrinologie.

[56]  F. Petraglia,et al.  Endocrinology of human parturition. , 2016, Annales d'endocrinologie.

[57]  H. Guan,et al.  Prenatal Exposure to Bisphenol A Disrupts Mouse Fetal Liver Maturation in a Sex‐Specific Manner , 2016, Journal of cellular biochemistry.

[58]  C. Oliveira,et al.  Disposition of inorganic mercury in pregnant rats and their offspring. , 2015, Toxicology.

[59]  G. Burton,et al.  The placenta: a multifaceted, transient organ , 2015, Philosophical Transactions of the Royal Society B: Biological Sciences.

[60]  M. Piasek,et al.  Cadmium in Placenta—A Valuable Biomarker of Exposure During Pregnancy in Biomedical Research , 2014, Journal of toxicology and environmental health. Part A.

[61]  J. Sneyd,et al.  The role of enzyme compartmentalization on the regulation of steroid synthesis. , 2013, Journal of theoretical biology.

[62]  C. Wood,et al.  Blockade of Estrogen Action Upregulates Estrogen Receptor-α mRNA in the Fetal Brain , 2009, Neonatology.

[63]  Y. Enli,et al.  Transmission electron microscopy study of the effects of cadmium and copper on fetal rat liver tissue , 2007, Biological Trace Element Research.

[64]  Jian-Ping Wang,et al.  Impact of electronic wastes recycling on environmental quality. , 2006, Biomedical and environmental sciences : BES.

[65]  M. Takigawa,et al.  Locally produced estrogen promotes fetal rat metatarsal bone growth; an effect mediated through increased chondrocyte proliferation and decreased apoptosis. , 2006, The Journal of endocrinology.

[66]  J. Pasqualini Enzymes involved in the formation and transformation of steroid hormones in the fetal and placental compartments , 2005, The Journal of Steroid Biochemistry and Molecular Biology.

[67]  C. Kallen Steroid hormone synthesis in pregnancy. , 2004, Obstetrics and gynecology clinics of North America.

[68]  Toulouse,et al.  Estradiol Alters Nitric Oxide Production in the Mouse Aorta Through the α-, but not β-, Estrogen Receptor , 2002 .

[69]  Thomas D. Schmittgen,et al.  Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. , 2001, Methods.

[70]  T. Taguchi,et al.  Influence of sex and age on the biological half-life of cadmium in mice. , 1981, Journal of toxicology and environmental health.

[71]  B. Vásárhelyi,et al.  [Estrogen metabolism during pregnancy]. , 2019, Orvosi Hetilap.

[72]  H. Nagase,et al.  Effect of gestational cadmium exposure on fetal growth, polyubiquitinated protein and monoubiqutin levels in the fetal liver of mice. , 2018, The Journal of toxicological sciences.

[73]  Biji T Kurien,et al.  Western blotting: an introduction. , 2015, Methods in molecular biology.

[74]  T. Erdmann,et al.  The influence of estrogen on liver regeneration: an experimental study in rats. , 2009, Acta cirurgica brasileira.

[75]  P. Ballard,et al.  Fetal lung maturation in estrogen-deprived baboons. , 2003, The Journal of clinical endocrinology and metabolism.