Portable qEEG and HD-tCS Device for Point-of-Injury Traumatic Brain Injury Diagnostics

Mild Traumatic Brain Injury (mTBI) can cause prolonged or permanent injuries if left undetected and ignored. It is therefore of great interest to lower the threshold for diagnosis of individuals with mTBI injury. We report on the development of a prototype of a portable quantified EEG (qEEG) system intended for in-the-field mTBI diagnostics. The 32-electrode system is fully battery driven, is interfaced with a control unit being part of a telemedicine care system. Electrode montage is a central problem effectively challenging measurements outside clinical environments. The system concept is unique in the sense that it will allow an automated montage process employing a flexible, disposable, one-size-fits-all electrode cap. All electrodes are individually configurable so that they can be used for both wet and dry qEEG electrodes. All electrodes can also be individually configured to allow Trans-Cranial Current Stimulation (tCS) sessions in DC, AC or other current supply modalities. The system has been functionality tested in end-to-end configurations where all control and measurement signals are forwarded between the head device on one side and the user interface and telemedicine system on the other. Tests confirm that the device can acquire and forward EEG data from 32 channels in parallel at target sensitivities up to 1 kHZ sampling frequencies. Additional device clinical evaluation is planned.

[1]  Frank Padberg,et al.  Transcranial direct current stimulation for acute major depressive episodes: Meta-analysis of individual patient data , 2016, British Journal of Psychiatry.

[2]  R. Thatcher,et al.  EEG discriminant analyses of mild head trauma. , 1989, Electroencephalography and clinical neurophysiology.

[3]  S. Rossi,et al.  Evidence-based guidelines on the therapeutic use of transcranial direct current stimulation (tDCS) , 2017, Clinical Neurophysiology.

[4]  K. V. von Wild,et al.  Head injury in Germany: A population-based prospective study on epidemiology, causes, treatment and outcome of all degrees of head-injury severity in two distinct areas , 2010, Brain injury.

[5]  J. Borg,et al.  Incidence, risk factors and prevention of mild traumatic brain injury: results of the WHO Collaborating Centre Task Force on Mild Traumatic Brain Injury. , 2004, Journal of rehabilitation medicine.

[6]  B. Jennett,et al.  Assessment of coma and impaired consciousness. A practical scale. , 1974, Lancet.

[7]  M. Bikson,et al.  Regulatory considerations for the clinical and research use of transcranial direct current stimulation (tDCS): Review and recommendations from an expert panel , 2015, Clinical research and regulatory affairs.

[8]  R. Brown,et al.  The value of the Glasgow Coma Scale and Injury Severity Score: predicting outcome in multiple trauma patients with head injury. , 1989, The Journal of trauma.

[9]  Alexandre Noyvirt,et al.  Automatic EEG processing for the early diagnosis of Traumatic Brain Injury , 2016, 2016 World Automation Congress (WAC).

[10]  B. Giordani,et al.  Disability caused by minor head injury. , 1981, Neurosurgery.

[11]  F. Servadei,et al.  A systematic review of brain injury epidemiology in Europe , 2006, Acta Neurochirurgica.

[12]  O. Carter,et al.  Evidence that transcranial direct current stimulation (tDCS) generates little-to-no reliable neurophysiologic effect beyond MEP amplitude modulation in healthy human subjects: A systematic review , 2015, Neuropsychologia.

[13]  Alexandre Noyvirt,et al.  Portable Decision Support for Diagnosis of Traumatic Brain Injury , 2016, KES.

[14]  R. Thatcher,et al.  An EEG severity index of traumatic brain injury. , 2001, The Journal of neuropsychiatry and clinical neurosciences.