Performance of non-invasive prenatal screening for sex chromosome aneuploidies and parental decision-making

P< 0.05 was considered statistically significant. In addiTo the Editor: Sex chromosomal aneuploidies (SCAs) are common chromosomal aberrations that are normally tion, positive predictive value (PPV) was calculated diagnosed after birth. It results in abnormal physical development or infertility. The prenatal incidence is as high as 1/435 and is usually identified by karyotyping. SCAs are characterized by an abnormal number of sex chromosomes and include monosomy (45, X), trisomy (47, XXX, 47, XXY, and 47, XYY), other aneuploidies and various forms of sex chromosome mosaicism. The phenotypes of SCA patients are diverse. The prenatal diagnosis of fetal SCAs affects the parents and there is a need for clinical counseling. What’s more, early diagnosis is important as it provides opportunities for early treatment and future healthcare for children with SCAs.