Isorhapontigenin, a bioavailable dietary polyphenol, suppresses airway epithelial cell inflammation through a corticosteroid‐independent mechanism

Chronic obstructive pulmonary disease (COPD) is a corticosteroid‐resistant airway inflammatory condition. Resveratrol exhibits anti‐inflammatory activities in COPD but has weak potency and poor pharmacokinetics. This study aimed to evaluate the potential of isorhapontigenin, another dietary polyphenol, as a novel anti‐inflammatory agent for COPD by examining its effects in vitro and pharmacokinetics in vivo.

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