Molecular biology of lung cancer: clinical implications.
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[1] F. Wang,et al. Octamer 4 Small Interfering RNA Results in Cancer Stem Cell-Like Cell Apoptosis , 2012 .
[2] Sébastien Couraud,et al. Lung cancer in never smokers--a review. , 2012, European journal of cancer.
[3] R. Rosell,et al. Combined VEGF-A and VEGFR-2 concentrations in plasma: diagnostic and prognostic implications in patients with advanced NSCLC. , 2011, Lung cancer.
[4] Leah E. Mechanic,et al. Frequent homozygous deletion of the LKB1/STK11 gene in non-small cell lung cancer , 2011, Oncogene.
[5] J Downward,et al. An siRNA screen identifies RSK1 as a key modulator of lung cancer metastasis , 2011, Oncogene.
[6] X. Chen,et al. Identification of ten serum microRNAs from a genome‐wide serum microRNA expression profile as novel noninvasive biomarkers for nonsmall cell lung cancer diagnosis , 2011, International journal of cancer.
[7] J. Shay,et al. Targeting telomerase-expressing cancer cells , 2011, Journal of cellular and molecular medicine.
[8] W. Pao,et al. How genetically engineered mouse tumor models provide insights into human cancers. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[9] Yi Zhu,et al. Identification of plasma microRNA-21 as a biomarker for early detection and chemosensitivity of non–small cell lung cancer , 2011, Chinese journal of cancer.
[10] A. Sood,et al. MicroRNA therapeutics: principles, expectations, and challenges , 2011, Chinese journal of cancer.
[11] S. Leng,et al. EMT and stem cell-like properties associated with miR-205 and miR-200 epigenetic silencing are early manifestations during carcinogen-induced transformation of human lung epithelial cells. , 2011, Cancer research.
[12] T. Itoh,et al. Oncogene-mediated human lung epithelial cell transformation produces adenocarcinoma phenotypes in vivo. , 2011, Cancer research.
[13] Wei Zhang,et al. Genetic and epigenetic changes in lung carcinoma and their clinical implications , 2011, Modern Pathology.
[14] D. Hanahan,et al. Hallmarks of Cancer: The Next Generation , 2011, Cell.
[15] F. Cui,et al. CD133 is a temporary marker of cancer stem cells in small cell lung cancer, but not in non-small cell lung cancer. , 2011, Oncology reports.
[16] Zhaoli Chen,et al. DNA hypermethylation of microRNA-34b/c has prognostic value for stage Ⅰ non-small cell lung cancer , 2011, Cancer biology & therapy.
[17] Vidar Skaug,et al. The Association of MicroRNA Expression with Prognosis and Progression in Early-Stage, Non–Small Cell Lung Adenocarcinoma: A Retrospective Analysis of Three Cohorts , 2011, Clinical Cancer Research.
[18] D. Gudbjartsson,et al. Genome-wide significant association between a sequence variant at 15q15.2 and lung cancer risk. , 2011, Cancer research.
[19] Derek Y. Chiang,et al. Suppression of Lung Adenocarcinoma Progression by Nkx2-1 , 2011, Nature.
[20] S. Wacholder,et al. Assessment of Human Papillomavirus in Lung Tumor Tissue , 2011, Journal of the National Cancer Institute.
[21] K. Fong,et al. Genomic medicine in non‐small cell lung cancer: Paving the path to personalized care , 2011, Respirology.
[22] J. Minna,et al. Knockdown of Oncogenic KRAS in Non–Small Cell Lung Cancers Suppresses Tumor Growth and Sensitizes Tumor Cells to Targeted Therapy , 2011, Molecular Cancer Therapeutics.
[23] Alan Ashworth,et al. Searching for synthetic lethality in cancer. , 2011, Current opinion in genetics & development.
[24] C. Sautès-Fridman,et al. Tumor microenvironment is multifaceted , 2011, Cancer and Metastasis Reviews.
[25] T. Dønnem,et al. Prognostic Impact of MiR-155 in Non-Small Cell Lung Cancer Evaluated by in Situ Hybridization , 2011, Journal of Translational Medicine.
[26] H. Osada,et al. let‐7 and miR‐17‐92: Small‐sized major players in lung cancer development , 2011, Cancer science.
[27] I. Petersen,et al. Frequent and Focal FGFR1 Amplification Associates with Therapeutically Tractable FGFR1 Dependency in Squamous Cell Lung Cancer , 2010, Science Translational Medicine.
[28] S. Chiou,et al. Coexpression of Oct4 and Nanog enhances malignancy in lung adenocarcinoma by inducing cancer stem cell-like properties and epithelial-mesenchymal transdifferentiation. , 2010, Cancer research.
[29] Feng Jiang,et al. Early detection of lung adenocarcinoma in sputum by a panel of microRNA markers , 2010, International journal of cancer.
[30] John D. Minna,et al. Nuclear Receptor Expression Defines a Set of Prognostic Biomarkers for Lung Cancer , 2010, PLoS medicine.
[31] S. Ramalingam. Histone Deacetylase, Proteasome, and Heat Shock Protein Inhibitors for the Treatment of Lung Cancer , 2010, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.
[32] P. Jänne,et al. Inhibition of ALK, PI3K/MEK, and HSP90 in murine lung adenocarcinoma induced by EML4-ALK fusion oncogene. , 2010, Cancer research.
[33] S. Dubinett,et al. Poly(ADP-Ribose) Polymerase Inhibitors , 2010, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.
[34] Laura A. Sullivan,et al. Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling. , 2010, Cancer research.
[35] J. Yokota,et al. Involvement of LKB1 in epithelial-mesenchymal transition (EMT) of human lung cancer cells. , 2010, Lung cancer.
[36] W. Hahn,et al. Wilms tumor 1 (WT1) regulates KRAS-driven oncogenesis and senescence in mouse and human models. , 2010, The Journal of clinical investigation.
[37] Alan Ashworth,et al. Synthetic lethal approaches to breast cancer therapy , 2010, Nature Reviews Clinical Oncology.
[38] Jonathan W. Pillow,et al. POSTER PRESENTATION Open Access , 2013 .
[39] S. Gabriel,et al. Advances in understanding cancer genomes through second-generation sequencing , 2010, Nature Reviews Genetics.
[40] A. Gazdar. Should we continue to use the term non-small-cell lung cancer? , 2010, Annals of oncology : official journal of the European Society for Medical Oncology.
[41] W. Park,et al. Global analysis of CpG methylation reveals epigenetic control of the radiosensitivity in lung cancer cell lines , 2010, Oncogene.
[42] L. Chirieac,et al. Sox2 Protein Expression is an Independent Poor Prognostic Indicator in Stage I Lung Adenocarcinoma , 2010, The American journal of surgical pathology.
[43] I. Yoshino,et al. Aberrant methylation in non-small cell lung cancer , 2010, Surgery Today.
[44] P. Wei,et al. Evaluation of Selective γ-Secretase Inhibitor PF-03084014 for Its Antitumor Efficacy and Gastrointestinal Safety to Guide Optimal Clinical Trial Design , 2010, Molecular Cancer Therapeutics.
[45] A. Sparks,et al. The mutation spectrum revealed by paired genome sequences from a lung cancer patient , 2010, Nature.
[46] J. Coon,et al. PTEN, RASSF1 and DAPK site‐specific hypermethylation and outcome in surgically treated stage I and II nonsmall cell lung cancer patients , 2010, International journal of cancer.
[47] Z. Herceg,et al. Aberrant DNA methylation links cancer susceptibility locus 15q25.1 to apoptotic regulation and lung cancer. , 2010, Cancer research.
[48] Marshall W. Anderson,et al. A susceptibility locus on chromosome 6q greatly increases lung cancer risk among light and never smokers. , 2010, Cancer research.
[49] Robert A. Weinberg,et al. Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model , 2010, Nature Biotechnology.
[50] John D. Minna,et al. Sex Determining Region Y-Box 2 (SOX2) Is a Potential Cell-Lineage Gene Highly Expressed in the Pathogenesis of Squamous Cell Carcinomas of the Lung , 2010, PloS one.
[51] A. Pertsemlidis,et al. microRNAs and lung cancer: tumors and 22-mers , 2010, Cancer and Metastasis Reviews.
[52] C. Sima,et al. Pack‐years of cigarette smoking as a prognostic factor in patients with stage IIIB/IV nonsmall cell lung cancer , 2010, Cancer.
[53] S. Zöchbauer-Müller,et al. Lung cancer: From single-gene methylation to methylome profiling , 2010, Cancer and Metastasis Reviews.
[54] John D. Minna,et al. Evidence for self-renewing lung cancer stem cells and their implications in tumor initiation, progression, and targeted therapy , 2010, Cancer and Metastasis Reviews.
[55] E. Birney,et al. A small cell lung cancer genome reports complex tobacco exposure signatures , 2009, Nature.
[56] J. Hornick,et al. Sox2 Expression in Pulmonary Non-small Cell and Neuroendocrine Carcinomas , 2010, Applied immunohistochemistry & molecular morphology : AIMM.
[57] Laura A. Sullivan,et al. Antiangiogenic therapy in lung cancer: focus on vascular endothelial growth factor pathway , 2010, Experimental biology and medicine.
[58] John R. Engen,et al. Novel mutant-selective EGFR kinase inhibitors against EGFR T790M , 2009, Nature.
[59] Raoul Tibes,et al. Inhibition of the hedgehog pathway in advanced basal-cell carcinoma. , 2009, The New England journal of medicine.
[60] John D. Minna,et al. Genomic and functional analysis identifies CRKL as an oncogene amplified in lung cancer , 2010 .
[61] K. Okudela,et al. Cancer stem cell: implications in cancer biology and therapy with special reference to lung cancer. , 2009, Lung cancer.
[62] M. Varella‐Garcia,et al. ALK Gene Rearrangements: A New Therapeutic Target in a Molecularly Defined Subset of Non-small Cell Lung Cancer , 2009, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.
[63] R. Huang,et al. Epithelial-Mesenchymal Transitions in Development and Disease , 2009, Cell.
[64] Julia Schüler,et al. The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs , 2009, Nature Cell Biology.
[65] Bernat Gel,et al. miR-34a as a prognostic marker of relapse in surgically resected non-small-cell lung cancer. , 2009, Carcinogenesis.
[66] A. Regev,et al. SOX2 Is an Amplified Lineage Survival Oncogene in Lung and Esophageal Squamous Cell Carcinomas , 2009, Nature Genetics.
[67] Marshall W. Anderson,et al. Haplotype and cell proliferation analyses of candidate lung cancer susceptibility genes on chromosome 15q24-25.1. , 2009, Cancer research.
[68] D. Carvajal,et al. Preclinical profile of a potent gamma-secretase inhibitor targeting notch signaling with in vivo efficacy and pharmacodynamic properties. , 2009, Cancer research.
[69] Y. Maehara,et al. Clinicopathological significance of Sip1-associated epithelial mesenchymal transition in non-small cell lung cancer progression. , 2009, Anticancer research.
[70] W. Hsu,et al. Prognostic significance of hypoxia-inducible factor-1α, TWIST1 and Snail expression in resectable non-small cell lung cancer , 2009, Thorax.
[71] L. Mariani,et al. Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment , 2009, Proceedings of the National Academy of Sciences.
[72] William Pao,et al. Lung Cancer in Never Smokers: Molecular Profiles and Therapeutic Implications , 2009, Clinical Cancer Research.
[73] Alexander Pertsemlidis,et al. Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression. , 2009, Genes & development.
[74] G. Viglietto,et al. The role of CD133 in the identification and characterisation of tumour-initiating cells in non-small-cell lung cancer. , 2009, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.
[75] M. Spitz,et al. Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study. , 2009, Cancer research.
[76] N. Girard,et al. Genomic and Mutational Profiling to Assess Clonal Relationships Between Multiple Non–Small Cell Lung Cancers , 2009, Clinical Cancer Research.
[77] A. Gazdar,et al. Activating and resistance mutations of EGFR in non-small-cell lung cancer: role in clinical response to EGFR tyrosine kinase inhibitors , 2009, Oncogene.
[78] G. Pirozzi,et al. Human CD34+/CD90+ ASCs Are Capable of Growing as Sphere Clusters, Producing High Levels of VEGF and Forming Capillaries , 2009, PloS one.
[79] John D. Minna,et al. miR-93, miR-98, and miR-197 Regulate Expression of Tumor Suppressor Gene FUS1 , 2009, Molecular Cancer Research.
[80] Ru-Fang Yeh,et al. Differentiation of lung adenocarcinoma, pleural mesothelioma, and nonmalignant pulmonary tissues using DNA methylation profiles. , 2009, Cancer research.
[81] A. Schetter,et al. MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers , 2009, Proceedings of the National Academy of Sciences.
[82] D. Beer,et al. MicroRNA classifiers for predicting prognosis of squamous cell lung cancer. , 2009, Cancer research.
[83] F. Esposito,et al. TRAP1, a novel mitochondrial chaperone responsible for multi-drug resistance and protection from apoptotis in human colorectal carcinoma cells. , 2009, Cancer letters.
[84] Patricia Greninger,et al. A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival. , 2009, Cancer cell.
[85] T. Rauch,et al. DNA methylation patterns in lung carcinomas. , 2009, Seminars in cancer biology.
[86] Michael J. Emanuele,et al. A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene , 2009, Cell.
[87] Sridhar Ramaswamy,et al. Synthetic Lethal Interaction between Oncogenic KRAS Dependency and STK33 Suppression in Human Cancer Cells , 2009, Cell.
[88] Gideon Rechavi,et al. Diagnostic assay based on hsa-miR-205 expression distinguishes squamous from nonsquamous non-small-cell lung carcinoma. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[89] Marshall W. Anderson,et al. Fine Mapping of Chromosome 6q23-25 Region in Familial Lung Cancer Families Reveals RGS17 as a Likely Candidate Gene , 2009, Clinical Cancer Research.
[90] J. Bankson,et al. The selective hypoxia inducible factor-1 inhibitor PX-478 provides in vivo radiosensitization through tumor stromal effects , 2009, Molecular Cancer Therapeutics.
[91] E. Scott,et al. Aldehyde dehydrogenase activity as a functional marker for lung cancer. , 2009, Chemico-biological interactions.
[92] C. Klinge,et al. Estradiol downregulates miR-21 expression and increases miR-21 target gene expression in MCF-7 breast cancer cells , 2009, Nucleic acids research.
[93] Akhilesh Pandey,et al. Identification of miR‐21 targets in breast cancer cells using a quantitative proteomic approach , 2009, Proteomics.
[94] Feng Jiang,et al. Aldehyde Dehydrogenase 1 Is a Tumor Stem Cell-Associated Marker in Lung Cancer , 2009, Molecular Cancer Research.
[95] G. Scagliotti,et al. Nonsmall cell lung cancer in never smokers , 2009, Current opinion in oncology.
[96] M. Stratton,et al. LKB1/KRAS mutant lung cancers constitute a genetic subset of NSCLC with increased sensitivity to MAPK and mTOR signalling inhibition , 2009, British Journal of Cancer.
[97] A. Sorkin,et al. RNA interference screen identifies Usp18 as a regulator of epidermal growth factor receptor synthesis. , 2009, Molecular biology of the cell.
[98] M. Meyerson,et al. HER2YVMA drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and rapamycin combination therapy , 2009, Proceedings of the National Academy of Sciences.
[99] H. Drabkin,et al. Semaphorins and their receptors in lung cancer. , 2009, Cancer letters.
[100] Giovanni Vanni Frajese,et al. The Inhibition of the Highly Expressed Mir-221 and Mir-222 Impairs the Growth of Prostate Carcinoma Xenografts in Mice , 2008, PloS one.
[101] Yu Liang. An expression meta-analysis of predicted microRNA targets identifies a diagnostic signature for lung cancer , 2008, BMC Medical Genomics.
[102] L. Penn,et al. Reflecting on 25 years with MYC , 2008, Nature Reviews Cancer.
[103] L. Bierut,et al. Nicotinic Receptor Gene Variants Influence Susceptibility to Heavy Smoking , 2008, Cancer Epidemiology Biomarkers & Prevention.
[104] Ralph Weissleder,et al. Effective Use of PI3K and MEK Inhibitors to Treat Mutant K-Ras G12D and PIK3CA H1047R Murine Lung Cancers , 2008, Nature Medicine.
[105] Maarit Tiirikainen,et al. Smokers with the CHRNA lung cancer-associated variants are exposed to higher levels of nicotine equivalents and a carcinogenic tobacco-specific nitrosamine. , 2008, Cancer research.
[106] N. Probst-Hensch,et al. Prognostic Significance of Epithelial-Mesenchymal and Mesenchymal-Epithelial Transition Protein Expression in Non–Small Cell Lung Cancer , 2008, Clinical Cancer Research.
[107] M. Spitz,et al. The CHRNA5-A3 region on chromosome 15q24-25.1 is a risk factor both for nicotine dependence and for lung cancer. , 2008, Journal of the National Cancer Institute.
[108] L. Siu,et al. First-in-class, first-in-human phase I results of targeted agents: Highlights of the 2008 American Society of Clinical Oncology meeting , 2008, Journal of hematology & oncology.
[109] J. Minna,et al. Semaphorin 3B inhibits the phosphatidylinositol 3-kinase/Akt pathway through neuropilin-1 in lung and breast cancer cells. , 2008, Cancer research.
[110] Brian H. Dunford-Shore,et al. Somatic mutations affect key pathways in lung adenocarcinoma , 2008, Nature.
[111] Vassilis Georgoulias,et al. Prognostic value of mature microRNA-21 and microRNA-205 overexpression in non-small cell lung cancer by quantitative real-time RT-PCR. , 2008, Clinical chemistry.
[112] F. Siannis,et al. Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer. , 2008, The Lancet. Oncology.
[113] Y. Yatabe,et al. Epidermal Growth Factor Receptor Mutations in Small Cell Lung Cancer , 2008, Clinical Cancer Research.
[114] J. Nevins,et al. Toward the individualization of lung cancer therapy , 2008, Cancer.
[115] S. Lippman,et al. Lung cancer. , 2008, The New England journal of medicine.
[116] Jinsong Liu,et al. Identification of a small molecule with synthetic lethality for K-ras and protein kinase C iota. , 2008, Cancer research.
[117] G. Nuovo,et al. MicroRNA-126 inhibits invasion in non-small cell lung carcinoma cell lines. , 2008, Biochemical and biophysical research communications.
[118] M. Nikiforova,et al. The Histopathology of BRAF-V600E–mutated Lung Adenocarcinoma , 2008, The American journal of surgical pathology.
[119] W. Lam,et al. PIK3CA mutations and copy number gains in human lung cancers. , 2008, Cancer research.
[120] Tatiana Foroud,et al. Variants in nicotinic receptors and risk for nicotine dependence. , 2008, The American journal of psychiatry.
[121] Anna E. Lokshin,et al. Drug-Selected Human Lung Cancer Stem Cells: Cytokine Network, Tumorigenic and Metastatic Properties , 2008, PloS one.
[122] Yang Xie,et al. Predicting the future for people with lung cancer , 2008, Nature Medicine.
[123] Igor Jurisica,et al. Gene expression–based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study , 2008, Nature Medicine.
[124] Yuh-Lih Chang,et al. Oct-4 Expression Maintained Cancer Stem-Like Properties in Lung Cancer-Derived CD133-Positive Cells , 2008, PloS one.
[125] Christoph Plass,et al. Lung cancer epigenetics and genetics , 2008, International journal of cancer.
[126] M. Meyerson,et al. Mutations in the LKB1 tumour suppressor are frequently detected in tumours from Caucasian but not Asian lung cancer patients , 2008, British Journal of Cancer.
[127] Robert A. Weinberg,et al. Ras oncogenes: split personalities , 2008, Nature Reviews Molecular Cell Biology.
[128] Megan E. Piper,et al. A Candidate Gene Approach Identifies the CHRNA5-A3-B4 Region as a Risk Factor for Age-Dependent Nicotine Addiction , 2008, PLoS genetics.
[129] A. A. Abd El-Aty,et al. Characterization of a stem cell population in lung cancer A549 cells. , 2008, Biochemical and biophysical research communications.
[130] C. Croce,et al. MicroRNA signatures of TRAIL resistance in human non-small cell lung cancer , 2008, Oncogene.
[131] I Petersen,et al. Genomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancer , 2008, Oncogene.
[132] Manuel Benito,et al. Telomere shortening is associated with poor prognosis and telomerase activity correlates with DNA repair impairment in non-small cell lung cancer. , 2008, Lung cancer.
[133] F. Hirsch,et al. EGFR regulation by microRNA in lung cancer: correlation with clinical response and survival to gefitinib and EGFR expression in cell lines. , 2008, Annals of oncology : official journal of the European Society for Medical Oncology.
[134] A. Adjei,et al. K-ras as a Target for Lung Cancer Therapy , 2008, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.
[135] Antony V. Cox,et al. Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing , 2008, Nature Genetics.
[136] M. Ladanyi,et al. Frequency and Distinctive Spectrum of KRAS Mutations in Never Smokers with Lung Adenocarcinoma , 2008, Clinical Cancer Research.
[137] Wenjun Guo,et al. The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells , 2008, Cell.
[138] G. Mills,et al. Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1 , 2008, Nature Genetics.
[139] G. Goodall,et al. The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1 , 2008, Nature Cell Biology.
[140] Mauro Biffoni,et al. The promyelocytic leukemia zinc finger-microRNA-221/-222 pathway controls melanoma progression through multiple oncogenic mechanisms. , 2008, Cancer research.
[141] Paolo Vineis,et al. A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25 , 2008, Nature.
[142] J. Roth,et al. Tumor suppressor FUS1 signaling pathway. , 2008, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.
[143] M. Gaub,et al. MET Gene Copy Number in Non-small Cell Lung Cancer: Molecular Analysis in a Targeted Tyrosine Kinase Inhibitor Naïve Cohort , 2008, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.
[144] Sun-Mi Park,et al. The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. , 2008, Genes & development.
[145] F. Slack,et al. The let-7 microRNA reduces tumor growth in mouse models of lung cancer , 2008, Cell cycle.
[146] Phillip A Sharp,et al. Suppression of non-small cell lung tumor development by the let-7 microRNA family , 2008, Proceedings of the National Academy of Sciences.
[147] A. Sakurada,et al. siRNA Targeting against EGFR, a Promising Candidate for a Novel Therapeutic Application to Lung Adenocarcinoma , 2008, Pathobiology.
[148] Hubert Vesselle,et al. DNA Methylation in Tumor and Matched Normal Tissues from Non-Small Cell Lung Cancer Patients , 2008, Cancer Epidemiology Biomarkers & Prevention.
[149] M. Biffoni,et al. Identification and expansion of the tumorigenic lung cancer stem cell population , 2008, Cell Death and Differentiation.
[150] Xihong Lin,et al. VEGF polymorphisms and survival in early-stage non-small-cell lung cancer. , 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[151] Hong Wu,et al. Pten inactivation accelerates oncogenic K-ras-initiated tumorigenesis in a mouse model of lung cancer. , 2008, Cancer research.
[152] M. Dohadwala,et al. Inflammation, epithelial to mesenchymal transition, and epidermal growth factor receptor tyrosine kinase inhibitor resistance. , 2008, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.
[153] Lang Li,et al. Association of polymorphisms of angiogenesis genes with breast cancer , 2008, Breast Cancer Research and Treatment.
[154] B. Eren,et al. MMP-2, TIMP-2 and CD44v6 expression in non-small-cell lung carcinomas. , 2008, Annals of the Academy of Medicine, Singapore.
[155] Xueyan Zhong,et al. High-resolution mapping of DNA hypermethylation and hypomethylation in lung cancer , 2008, Proceedings of the National Academy of Sciences.
[156] Sung-Liang Yu,et al. MicroRNA signature predicts survival and relapse in lung cancer. , 2008, Cancer cell.
[157] Diane D. Liu,et al. Loss and Reduction of Fus1 Protein Expression is a Frequent Phenomenon in the Pathogenesis of Lung Cancer , 2008, Clinical Cancer Research.
[158] Dong Sun Kim,et al. Aberrant methylation of E‐cadherin and H‐cadherin genes in nonsmall cell lung cancer and its relation to clinicopathologic features , 2007, Cancer.
[159] Laura A. Sullivan,et al. Global Survey of Phosphotyrosine Signaling Identifies Oncogenic Kinases in Lung Cancer , 2007, Cell.
[160] Derek Y. Chiang,et al. Characterizing the cancer genome in lung adenocarcinoma , 2007, Nature.
[161] W. Gerald,et al. Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas. , 2007, The Journal of clinical investigation.
[162] Imran Babar,et al. MicroRNAs as potential agents to alter resistance to cytotoxic anticancer therapy. , 2007, Cancer research.
[163] R. Kurzrock,et al. Interleukin‐6 and its receptor in cancer , 2007, Cancer.
[164] William Pao,et al. MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib , 2007, Proceedings of the National Academy of Sciences.
[165] Jude Kendall,et al. Oncogenic cooperation and coamplification of developmental transcription factor genes in lung cancer , 2007, Proceedings of the National Academy of Sciences.
[166] M. Lauth,et al. Non-Canonical Activation of GLI Transcription Factors: Implications for Targeted Anti-Cancer Therapy , 2007, Cell cycle.
[167] C. Morrison,et al. MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B , 2007, Proceedings of the National Academy of Sciences.
[168] A. Gazdar,et al. Lung cancer in never smokers — a different disease , 2007, Nature Reviews Cancer.
[169] J. Minna,et al. Prevalence and specificity of LKB1 genetic alterations in lung cancers , 2007, Oncogene.
[170] W. Pao,et al. Development of New Mouse Lung Tumor Models Expressing EGFR T790M Mutants Associated with Clinical Resistance to Kinase Inhibitors , 2007, PloS one.
[171] D. Neil Hayes,et al. LKB1 modulates lung cancer differentiation and metastasis , 2007, Nature.
[172] F. Slack,et al. The let-7 microRNA represses cell proliferation pathways in human cells. , 2007, Cancer research.
[173] H. Aburatani,et al. Identification of the transforming EML4–ALK fusion gene in non-small-cell lung cancer , 2007, Nature.
[174] J. Park,et al. Aberrant DNA methylation profiles of non-small cell lung cancers in a Korean population. , 2007, Lung cancer.
[175] David M Sabatini,et al. Defining the role of mTOR in cancer. , 2007, Cancer cell.
[176] Y. Yatabe,et al. Lineage-specific dependency of lung adenocarcinomas on the lung development regulator TTF-1. , 2007, Cancer research.
[177] Y. Tomizawa,et al. Epigenetic inactivation of the RAS-effector gene RASSF2 in lung cancers. , 2007, International journal of oncology.
[178] Joon-Oh Park,et al. MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling , 2007, Science.
[179] Levi A Garraway,et al. Mutations in BRAF and KRAS converge on activation of the mitogen-activated protein kinase pathway in lung cancer mouse models. , 2007, Cancer research.
[180] Stephen Lam,et al. Side population in human lung cancer cell lines and tumors is enriched with stem-like cancer cells. , 2007, Cancer research.
[181] Anindya Dutta,et al. The tumor suppressor microRNA let-7 represses the HMGA2 oncogene. , 2007, Genes & development.
[182] G. Sauter,et al. Estrogen receptor alpha (ESR1) gene amplification is frequent in breast cancer , 2007, Nature Genetics.
[183] M. Bittner,et al. Chromosomal aberrations and gene expression profiles in non-small cell lung cancer. , 2007, Lung cancer.
[184] Shuomin Zhu,et al. miR-21-mediated tumor growth , 2007, Oncogene.
[185] K. Robertson,et al. Pharmacologic inhibition of epigenetic modifications, coupled with gene expression profiling, reveals novel targets of aberrant DNA methylation and histone deacetylation in lung cancer , 2007, Oncogene.
[186] Michael Peyton,et al. Synthetic lethal screen identification of chemosensitizer loci in cancer cells , 2007, Nature.
[187] David P. Bartel,et al. Supporting Online Material Materials and Methods Fig. S1 Tables S1 and S2 References Database S1 Disrupting the Pairing between Let-7 and Hmga2 Enhances Oncogenic Transformation , 2022 .
[188] G. Dakubo,et al. Clinical implications and utility of field cancerization , 2007, Cancer Cell International.
[189] Sandya Liyanarachchi,et al. Aberrant DNA Methylation of OLIG1, a Novel Prognostic Factor in Non-Small Cell Lung Cancer , 2007, PLoS medicine.
[190] C. Shih,et al. Identification of uPAR-positive Chemoresistant Cells in Small Cell Lung Cancer , 2007, PloS one.
[191] E. Dmitrovsky,et al. Frequent requirement of hedgehog signaling in non-small cell lung carcinoma , 2007, Oncogene.
[192] T. Jacks,et al. Restoration of p53 function leads to tumour regression in vivo , 2007, Nature.
[193] B. Telfer,et al. Combining radiotherapy with AZD2171, a potent inhibitor of vascular endothelial growth factor signaling: pathophysiologic effects and therapeutic benefit , 2007, Molecular Cancer Therapeutics.
[194] J. Minna,et al. Synergistic tumor suppression by coexpression of FUS1 and p53 is associated with down-regulation of murine double minute-2 and activation of the apoptotic protease-activating factor 1-dependent apoptotic pathway in human non-small cell lung cancer cells. , 2007, Cancer research.
[195] W. Cai,et al. High resolution analysis of genomic aberrations by metaphase and array comparative genomic hybridization identifies candidate tumour genes in lung cancer cell lines. , 2007, Cancer letters.
[196] M. Spitz,et al. Aberrant Promoter Methylation Profile and Association with Survival in Patients with Non–Small Cell Lung Cancer , 2006, Clinical Cancer Research.
[197] Robert Gray,et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. , 2006, The New England journal of medicine.
[198] Lee L. Rubin,et al. Targeting the Hedgehog pathway in cancer , 2006, Nature Reviews Drug Discovery.
[199] W. Gerald,et al. A Genome-Wide Screen for Promoter Methylation in Lung Cancer Identifies Novel Methylation Markers for Multiple Malignancies , 2006, PLoS medicine.
[200] Yeul-Hong Kim,et al. Comparative Genomic Hybridization Array Analysis and Real-Time PCR Reveals Genomic Copy Number Alteration for Lung Adenocarcinomas , 2006, Lung.
[201] H. Sasaki,et al. PIK3CA mutation status in Japanese lung cancer patients. , 2006, Lung cancer.
[202] William Pao,et al. Novel D761Y and Common Secondary T790M Mutations in Epidermal Growth Factor Receptor–Mutant Lung Adenocarcinomas with Acquired Resistance to Kinase Inhibitors , 2006, Clinical Cancer Research.
[203] Irving L Weissman,et al. Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells. , 2006, Cancer research.
[204] M. Tsuboi,et al. Analysis of Epidermal Growth Factor Receptor Gene Mutation in Patients with Non–Small Cell Lung Cancer and Acquired Resistance to Gefitinib , 2006, Clinical Cancer Research.
[205] L. Heasley,et al. Antitumorigenic Effect of Wnt 7a and Fzd 9 in Non-small Cell Lung Cancer Cells Is Mediated through ERK-5-dependent Activation of Peroxisome Proliferator-activated Receptor γ* , 2006, Journal of Biological Chemistry.
[206] A. Villemain,et al. The role of the vascular endothelial growth factor-Delta-like 4 ligand/Notch4-ephrin B2 cascade in tumor vessel remodeling and endothelial cell functions. , 2006, Cancer research.
[207] Ji Luo,et al. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism , 2006, Nature Reviews Genetics.
[208] W. Sellers,et al. Lineage dependency and lineage-survival oncogenes in human cancer , 2006, Nature Reviews Cancer.
[209] N. Riobo,et al. Hedgehog Signal Transduction: Signal Integration and Cross Talk in Development and Cancer , 2006, Cell cycle.
[210] C. Swanton,et al. Her2-Targeted Therapies in Non–Small Cell Lung Cancer , 2006, Clinical Cancer Research.
[211] H. Sasaki,et al. Uncommon V599E BRAF mutations in Japanese patients with lung cancer. , 2006, The Journal of surgical research.
[212] P. Jänne,et al. The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies. , 2006, Cancer cell.
[213] H. Varmus,et al. Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors. , 2006, Genes & development.
[214] H. Koong,et al. Never-smokers with lung cancer: epidemiologic evidence of a distinct disease entity. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[215] M. Meyerson,et al. Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[216] R. Cameron,et al. Cyclooxygenase-2-dependent regulation of E-cadherin: prostaglandin E(2) induces transcriptional repressors ZEB1 and snail in non-small cell lung cancer. , 2006, Cancer research.
[217] D. N. Watkins,et al. Developmental signalling pathways in lung cancer , 2006, Respirology.
[218] Y. Shim,et al. Cohypermethylation of p16 and FHIT promoters as a prognostic factor of recurrence in surgically resected stage I non-small cell lung cancer. , 2006, Cancer research.
[219] F. Slack,et al. Oncomirs — microRNAs with a role in cancer , 2006, Nature Reviews Cancer.
[220] Raghu Kalluri,et al. The epithelial–mesenchymal transition: new insights in signaling, development, and disease , 2006, The Journal of cell biology.
[221] S. Lam,et al. High resolution analysis of non‐small cell lung cancer cell lines by whole genome tiling path array CGH , 2006, International journal of cancer.
[222] R. Stephens,et al. Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. , 2006, Cancer cell.
[223] Wei Jiang,et al. High-throughput DNA methylation profiling using universal bead arrays. , 2006, Genome research.
[224] D. Sugarbaker,et al. Effectiveness of trichostatin A as a potential candidate for anticancer therapy in non-small-cell lung cancer. , 2006, The Annals of thoracic surgery.
[225] Mariette Schrier,et al. A Genetic Screen Implicates miRNA-372 and miRNA-373 As Oncogenes in Testicular Germ Cell Tumors , 2006, Cell.
[226] J. Minna,et al. Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. , 2006, Journal of the National Cancer Institute.
[227] Max S Wicha,et al. Cancer stem cells: an old idea--a paradigm shift. , 2006, Cancer research.
[228] J. Minna,et al. Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells. , 2006, Cancer research.
[229] C. Croce,et al. A microRNA expression signature of human solid tumors defines cancer gene targets , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[230] I. Wistuba,et al. Lung cancer preneoplasia. , 2006, Annual review of pathology.
[231] P. Tamboli,et al. Phase I studies of imatinib mesylate combined with cisplatin and irinotecan in patients with small cell lung carcinoma , 2006, Cancer.
[232] A. Gazdar,et al. Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers , 2006, International journal of cancer.
[233] G. Cavet,et al. Epithelial versus Mesenchymal Phenotype Determines In vitro Sensitivity and Predicts Clinical Activity of Erlotinib in Lung Cancer Patients , 2005, Clinical Cancer Research.
[234] N. Carter,et al. Genome-Wide Screening of Genomic Alterations and Their Clinicopathologic Implications in Non–Small Cell Lung Cancers , 2005, Clinical Cancer Research.
[235] J. Minna,et al. Identification of chromosome arm 9p as the most frequent target of homozygous deletions in lung cancer , 2005, Genes, chromosomes & cancer.
[236] T. Jacks,et al. The differential effects of mutant p53 alleles on advanced murine lung cancer. , 2005, Cancer research.
[237] Y. Yatabe,et al. A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation. , 2005, Cancer research.
[238] E. Brown,et al. Epithelial to mesenchymal transition is a determinant of sensitivity of non-small-cell lung carcinoma cell lines and xenografts to epidermal growth factor receptor inhibition. , 2005, Cancer research.
[239] J. Gills,et al. Inhibition of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway but not the MEK/ERK pathway attenuates laminin-mediated small cell lung cancer cellular survival and resistance to imatinib mesylate or chemotherapy. , 2005, Cancer research.
[240] Takayuki Fukui,et al. Transcriptional silencing of secreted frizzled related protein 1 (SFRP1) by promoter hypermethylation in non-small-cell lung cancer , 2005, Oncogene.
[241] J. Dick,et al. Cancer stem cells: lessons from leukemia. , 2005, Trends in cell biology.
[242] S. Hirohashi,et al. Genetic Classification of Lung Adenocarcinoma Based on Array-Based Comparative Genomic Hybridization Analysis: Its Association with Clinicopathologic Features , 2005, Clinical Cancer Research.
[243] Andrew D. Yates,et al. Somatic mutations of the protein kinase gene family in human lung cancer. , 2005, Cancer research.
[244] N. Hay,et al. The Akt-mTOR tango and its relevance to cancer. , 2005, Cancer cell.
[245] M. Ostland,et al. Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[246] M. Eilers,et al. Transcriptional regulation and transformation by Myc proteins , 2005, Nature Reviews Molecular Cell Biology.
[247] G. Ito,et al. Frequent inactivation of RASSF1A, BLU, and SEMA3B on 3p21.3 by promoter hypermethylation and allele loss in non-small cell lung cancer. , 2005, Cancer letters.
[248] T. Golub,et al. Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma , 2005, Nature.
[249] L. Chin,et al. High-resolution genomic profiles of human lung cancer. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[250] M. Meyerson,et al. Homozygous deletions and chromosome amplifications in human lung carcinomas revealed by single nucleotide polymorphism array analysis. , 2005, Cancer research.
[251] Kathryn A. O’Donnell,et al. c-Myc-regulated microRNAs modulate E2F1 expression , 2005, Nature.
[252] S. Lowe,et al. A microRNA polycistron as a potential human oncogene , 2005, Nature.
[253] Patricia L. Harris,et al. Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[254] N. Normanno,et al. The ErbB receptors and their ligands in cancer: an overview. , 2005, Current drug targets.
[255] F. Latif,et al. Role of the Ras-association domain family 1 tumor suppressor gene in human cancers. , 2005, Cancer research.
[256] E. Smit,et al. Molecular Pathology of Non-Small-Cell Lung Cancer , 2005, Respiration.
[257] F. Slack,et al. RAS Is Regulated by the let-7 MicroRNA Family , 2005, Cell.
[258] Wayne Tam,et al. Accumulation of miR-155 and BIC RNA in human B cell lymphomas. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[259] M. Meyerson,et al. EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. , 2005, The New England journal of medicine.
[260] H. Varmus,et al. Acquired Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib Is Associated with a Second Mutation in the EGFR Kinase Domain , 2005, PLoS medicine.
[261] Suk Woo Nam,et al. PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas , 2005, Oncogene.
[262] S. Knuutila,et al. CDK4 is a probable target gene in a novel amplicon at 12q13.3–q14.1 in lung cancer , 2005, Genes, chromosomes & cancer.
[263] A. Dudek,et al. Circulating Angiogenic Cytokines in Patients with Advanced Non-Small Cell Lung Cancer: Correlation with Treatment Response and Survival , 2005, Cancer investigation.
[264] M. Cronin,et al. A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. , 2004, The New England journal of medicine.
[265] T. Jacks,et al. Mutant p53 Gain of Function in Two Mouse Models of Li-Fraumeni Syndrome , 2004, Cell.
[266] Takayuki Kosaka,et al. Mutations of the Epidermal Growth Factor Receptor Gene in Lung Cancer , 2004, Cancer Research.
[267] J. Pollack,et al. Immortalization of Human Bronchial Epithelial Cells in the Absence of Viral Oncoproteins , 2004, Cancer Research.
[268] M Paesmans,et al. The role of RAS oncogene in survival of patients with lung cancer: a systematic review of the literature with meta-analysis , 2004, British Journal of Cancer.
[269] Li Mao,et al. Prognostic factors in resected stage I non-small-cell lung cancer: a multivariate analysis of six molecular markers. , 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[270] G. Watkins,et al. The possible correlation of Notch-1 and Notch-2 with clinical outcome and tumour clinicopathological parameters in human breast cancer. , 2004, International journal of molecular medicine.
[271] K. Politi,et al. Notch in mammary gland development and breast cancer. , 2004, Seminars in cancer biology.
[272] Andrew D. Yates,et al. Athletics: Momentous sprint at the 2156 Olympics? , 2004, Nature.
[273] Diane D. Liu,et al. Value of p16INK4a and RASSF1A Promoter Hypermethylation in Prognosis of Patients with Resectable Non–Small Cell Lung Cancer , 2004, Clinical Cancer Research.
[274] R. Wilson,et al. EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[275] Marshall W. Anderson,et al. A major lung cancer susceptibility locus maps to chromosome 6q23-25. , 2004, American journal of human genetics.
[276] F. Jiang,et al. Genomic profiles in stage I primary non small cell lung cancer using comparative genomic hybridization analysis of cDNA microarrays. , 2004, Neoplasia.
[277] Daniel A. Haber,et al. Gefitinib-Sensitizing EGFR Mutations in Lung Cancer Activate Anti-Apoptotic Pathways , 2004, Science.
[278] K. Uematsu,et al. Inhibition of Wnt-2-mediated signaling induces programmed cell death in non-small-cell lung cancer cells , 2004, Oncogene.
[279] G. Rubanyi,et al. Hedgehog-interacting protein is highly expressed in endothelial cells but down-regulated during angiogenesis and in several human tumors , 2004, BMC Cancer.
[280] H. Kato,et al. Hypermethylation of E-cadherin gene is frequent and independent of p16INK4A methylation in non-small cell lung cancer: potential prognostic implication. , 2004, Oncology reports.
[281] G. Bepler,et al. Improved survival in never-smokers vs current smokers with primary adenocarcinoma of the lung. , 2004, Chest.
[282] Kimi Yamakoshi,et al. The p16INK4a-RB pathway: molecular link between cellular senescence and tumor suppression. , 2004, The journal of medical investigation : JMI.
[283] Napoleone Ferrara,et al. Vascular endothelial growth factor: basic science and clinical progress. , 2004, Endocrine reviews.
[284] S. Toyooka,et al. The relationship between aberrant methylation and survival in non-small-cell lung cancers , 2004, British Journal of Cancer.
[285] Biao He,et al. Wnt Inhibitory Factor-1 Is Silenced by Promoter Hypermethylation in Human Lung Cancer , 2004, Cancer Research.
[286] G. Celik,et al. The prognostic significance of vascular endothelial growth factor levels in sera of non-small cell lung cancer patients. , 2004, Respiratory medicine.
[287] R. DePinho,et al. The LKB1 tumor suppressor negatively regulates mTOR signaling. , 2004, Cancer cell.
[288] Y. Shim,et al. Tumor-specific methylation in bronchial lavage for the early detection of non-small-cell lung cancer. , 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[289] J. Minna,et al. Different Roles for Caveolin-1 in the Development of Non-Small Cell Lung Cancer versus Small Cell Lung Cancer , 2004, Cancer Research.
[290] S. Gabriel,et al. EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy , 2004, Science.
[291] Roy S Herbst,et al. Review of epidermal growth factor receptor biology. , 2004, International journal of radiation oncology, biology, physics.
[292] Y. Yatabe,et al. Reduced Expression of the let-7 MicroRNAs in Human Lung Cancers in Association with Shortened Postoperative Survival , 2004, Cancer Research.
[293] Patricia L. Harris,et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. , 2004, The New England journal of medicine.
[294] J. Carretero,et al. Novel and natural knockout lung cancer cell lines for the LKB1/STK11 tumor suppressor gene , 2004, Oncogene.
[295] Hiroyuki Tagawa,et al. Identification and characterization of a novel gene, C13orf25, as a target for 13q31-q32 amplification in malignant lymphoma. , 2004, Cancer research.
[296] J. Ptak,et al. High Frequency of Mutations of the PIK3CA Gene in Human Cancers , 2004, Science.
[297] Masahide Takahashi,et al. p53 apoptotic pathway molecules are frequently and simultaneously altered in nonsmall cell lung carcinoma , 2004, Cancer.
[298] R. Dziadziuszko,et al. MDM2 gene amplification: a new independent factor of adverse prognosis in non-small cell lung cancer (NSCLC). , 2004, Lung cancer.
[299] G. Neufeld,et al. Semaphorin-3F Is an Inhibitor of Tumor Angiogenesis , 2004, Cancer Research.
[300] Arndt Borkhardt,et al. High expression of precursor microRNA‐155/BIC RNA in children with Burkitt lymphoma , 2004, Genes, chromosomes & cancer.
[301] C. Harris,et al. Tobacco Carcinogen-Induced Cellular Transformation Increases Activation of the Phosphatidylinositol 3′-Kinase/Akt Pathway in Vitro and in Vivo , 2004, Cancer Research.
[302] Biao He,et al. Activation of the Wnt pathway in non small cell lung cancer: evidence of dishevelled overexpression , 2003, Oncogene.
[303] Chan Zeng,et al. Epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis. , 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[304] S. Anttila,et al. Aberrant p16 promoter methylation in smokers and former smokers with nonsmall cell lung cancer , 2003, International journal of cancer.
[305] Christian Pilarsky,et al. WIF1, a component of the Wnt pathway, is down‐regulated in prostate, breast, lung, and bladder cancer , 2003, The Journal of pathology.
[306] Michael Z Michael,et al. Reduced accumulation of specific microRNAs in colorectal neoplasia. , 2003, Molecular cancer research : MCR.
[307] B. Osborne,et al. Notch signaling as a therapeutic target in cancer: a new approach to the development of cell fate modifying agents , 2003, Oncogene.
[308] David E. Misek,et al. Increased C-CRK proto-oncogene expression is associated with an aggressive phenotype in lung adenocarcinomas , 2003, Oncogene.
[309] A. Berns,et al. Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model. , 2003, Cancer cell.
[310] Seth M Steinberg,et al. A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. , 2003, The New England journal of medicine.
[311] Y. Shim,et al. Hypermethylation of RASSF1A promoter is associated with the age at starting smoking and a poor prognosis in primary non-small cell lung cancer. , 2003, Cancer research.
[312] C. Croce,et al. Allelic loss on chromosome 3p21.3 and promoter hypermethylation of semaphorin 3B in non-small cell lung cancer. , 2003, Cancer research.
[313] W. Koh,et al. Survival among Chinese women with lung cancer in Singapore: a comparison by stage, histology and smoking status. , 2003, Lung cancer.
[314] Y. Nishiwaki,et al. Frequent overexpression of the c-kit protein in large cell neuroendocrine carcinoma of the lung. , 2003, Lung cancer.
[315] T. Dang,et al. Constitutive activation of Notch3 inhibits terminal epithelial differentiation in lungs of transgenic mice , 2003, Oncogene.
[316] Stephen B. Baylin,et al. Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer , 2003, Nature.
[317] Samuel Singer,et al. PDGFRA Activating Mutations in Gastrointestinal Stromal Tumors , 2003, Science.
[318] S. Turner,et al. Gleevec (STI-571) inhibits lung cancer cell growth (A549) and potentiates the cisplatin effect in vitro , 2003, Molecular Cancer.
[319] M. Meyerson,et al. Missense mutations of the BRAF gene in human lung adenocarcinoma. , 2002, Cancer research.
[320] C. Croce,et al. Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[321] T. Hirano,et al. Molecular basis of the cell specificity of cytokine action. , 2002, Biochimica et biophysica acta.
[322] J. Testa,et al. Chromosomal imbalances in human lung cancer , 2002, Oncogene.
[323] R. Salgia,et al. Activated c‐Met signals through PI3K with dramatic effects on cytoskeletal functions in small cell lung cancer , 2002, Journal of cellular and molecular medicine.
[324] J. Minna,et al. Aberrant DNA methylation in lung cancer: biological and clinical implications. , 2002, The oncologist.
[325] Arvind Virmani,et al. Loss of retinoic acid receptor beta gene expression is linked to aberrant histone H3 acetylation in lung cancer cell lines. , 2002, Cancer research.
[326] I. Weinstein. Addiction to Oncogenes--the Achilles Heal of Cancer , 2002, Science.
[327] W. Hahn,et al. Immortalization and transformation of primary human airway epithelial cells by gene transfer , 2002, Oncogene.
[328] David Sidransky,et al. Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung. , 2002, Cancer research.
[329] C. Sawyers,et al. The phosphatidylinositol 3-Kinase–AKT pathway in human cancer , 2002, Nature Reviews Cancer.
[330] J. Minna,et al. Clinicopathological significance of epigenetic inactivation of RASSF1A at 3p21.3 in stage I lung adenocarcinoma. , 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.
[331] Ajay N. Jain,et al. Genomic copy number analysis of non-small cell lung cancer using array comparative genomic hybridization: implications of the phosphatidylinositol 3-kinase pathway. , 2002, Cancer research.
[332] A. Nicholson,et al. Mutations of the BRAF gene in human cancer , 2002, Nature.
[333] J. Thiery. Epithelial–mesenchymal transitions in tumour progression , 2002, Nature Reviews Cancer.
[334] A. Potti,et al. Predictive role of HER-2/neu overexpression and clinical features at initial presentation in patients with extensive stage small cell lung carcinoma. , 2002, Lung cancer.
[335] Li Mao,et al. Lack of PTEN expression in non-small cell lung cancer could be related to promoter methylation. , 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.
[336] F. Hirsch,et al. Epidermal growth factor receptor family in lung cancer and premalignancy. , 2002, Seminars in oncology.
[337] R. Vonderheide. Telomerase as a universal tumor-associated antigen for cancer immunotherapy , 2002, Oncogene.
[338] D. Sidransky,et al. Quantitative adenomatous polyposis coli promoter methylation analysis in tumor tissue, serum, and plasma DNA of patients with lung cancer. , 2002, Cancer research.
[339] H. Varmus,et al. Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes. , 2001, Genes & development.
[340] J. Minna,et al. Aberrant promoter methylation profile of bladder cancer and its relationship to clinicopathological features. , 2001, Cancer research.
[341] T. Jacks,et al. Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. , 2001, Genes & development.
[342] J. Minna,et al. Inhibition of lung cancer cell growth and induction of apoptosis after reexpression of 3p21.3 candidate tumor suppressor gene SEMA3B , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[343] J. Minna,et al. DNA methylation profiles of lung tumors. , 2001, Molecular cancer therapeutics.
[344] I. Weissman,et al. Stem cells, cancer, and cancer stem cells , 2001, Nature.
[345] S. Linn,et al. Mouse model for lung tumorigenesis through Cre/lox controlled sporadic activation of the K-Ras oncogene , 2001, Oncogene.
[346] David Sidransky,et al. Adenomatous polyposis coli gene promoter hypermethylation in non-small cell lung cancer is associated with survival , 2001, Oncogene.
[347] F. Oesch,et al. c‐erbB‐2 Expression in small‐cell lung cancer is associated with poor prognosis , 2001, International journal of cancer.
[348] P. Dennis,et al. Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation. , 2001, Cancer research.
[349] J. Minna,et al. Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression. , 2001, Journal of the National Cancer Institute.
[350] J. Minna,et al. 5' CpG island methylation of the FHIT gene is correlated with loss of gene expression in lung and breast cancer. , 2001, Cancer research.
[351] John K. Wiencke,et al. p16INK4a and Histology-specific Methylation of CpG Islands by Exposure to Tobacco Smoke in Non-Small Cell Lung Cancer , 2001 .
[352] J. Minna,et al. Molecular genetics of small cell lung carcinoma. , 2001, Seminars in oncology.
[353] J. Herman,et al. Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer. , 2001, Human molecular genetics.
[354] C. Harris,et al. Genetic polymorphisms in DNA repair genes and risk of lung cancer. , 2001, Carcinogenesis.
[355] E. Mark,et al. Promoter methylation of DAP-kinase: association with advanced stage in non-small cell lung cancer , 2001, Oncogene.
[356] R. Herrmann,et al. Adenovirus-mediated wild-type p53 gene transfer in patients receiving chemotherapy for advanced non-small-cell lung cancer: results of a multicenter phase II study. , 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[357] M. Tsao,et al. Molecular cytogenetic analysis of non-small cell lung carcinoma by spectral karyotyping and comparative genomic hybridization. , 2001, Cancer genetics and cytogenetics.
[358] S. Piantadosi,et al. Chromosomal alterations in lung adenocarcinoma from smokers and nonsmokers. , 2001, Cancer research.
[359] M. Tockman,et al. Polymorphisms of the DNA repair gene XRCC1 and lung cancer risk. , 2001, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
[360] J. Minna,et al. Promoter methylation and silencing of the retinoic acid receptor-beta gene in lung carcinomas. , 2001, Journal of the National Cancer Institute.
[361] R. Dillman,et al. Optimizing the use of rituximab for treatment of B-cell non-Hodgkin's lymphoma: a benefit-risk update. , 2000, Seminars in oncology.
[362] J. Herman,et al. Predicting lung cancer by detecting aberrant promoter methylation in sputum. , 2000, Cancer research.
[363] J. Roth,et al. Gene replacement strategies for treating non-small cell lung cancer. , 2000, Seminars in radiation oncology.
[364] T. Mitsudomi,et al. Prognostic significance of p53 alterations in patients with non-small cell lung cancer: a meta-analysis. , 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.
[365] F. Khuri,et al. Hypermethylation of the death-associated protein (DAP) kinase promoter and aggressiveness in stage I non-small-cell lung cancer. , 2000, Journal of the National Cancer Institute.
[366] J. Minna,et al. Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer, and loci clustering. , 2000, Cancer research.
[367] M. Bottomley,et al. Identification of polymorphisms within the vascular endothelial growth factor (VEGF) gene: correlation with variation in VEGF protein production. , 2000, Cytokine.
[368] T. Mitsudomi,et al. Expression of human telomerase subunit genes in primary lung cancer and its clinical significance. , 2000, The Annals of thoracic surgery.
[369] R. Salgia,et al. Growth inhibition and modulation of kinase pathways of small cell lung cancer cell lines by the novel tyrosine kinase inhibitor STI 571 , 2000, Oncogene.
[370] J. Minna,et al. Molecular changes in the bronchial epithelium of patients with small cell lung cancer. , 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.
[371] Chun Xing Li,et al. Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3 , 2000, Nature Genetics.
[372] P. Slootweg,et al. Gain-of-function mutations in the tumor suppressor gene p53. , 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.
[373] B. Kupelnick,et al. Prognostic significance of p53 mutations in non-small cell lung cancer: a meta-analysis of 829 cases from eight published studies. , 2000, Cancer letters.
[374] J. Herman,et al. CpG methylation is maintained in human cancer cells lacking DNMT1 , 2000, Nature.
[375] S. Lam,et al. High resolution chromosome 3p allelotyping of human lung cancer and preneoplastic/preinvasive bronchial epithelium reveals multiple, discontinuous sites of 3p allele loss and three regions of frequent breakpoints. , 2000, Cancer research.
[376] C. Der,et al. Understanding Ras: 'it ain't over 'til it's over'. , 2000, Trends in cell biology.
[377] T. Liloglou,et al. Evaluation of telomerase activity in bronchial lavage as a potential diagnostic marker for malignant lung disease. , 2000, Lung cancer.
[378] K. O'Byrne,et al. Vascular endothelial growth factor, platelet-derived endothelial cell growth factor and angiogenesis in non-small-cell lung cancer , 2000, British Journal of Cancer.
[379] E. Brambilla,et al. Semaphorin SEMA3F localization in malignant human lung and cell lines: A suggested role in cell adhesion and cell migration. , 2000, The American journal of pathology.
[380] D. Harpole,et al. Molecular biologic substaging of stage I lung cancer according to gender and histology. , 2000, The Annals of thoracic surgery.
[381] J. Minna,et al. Loss of Fhit expression in non-small-cell lung cancer: correlation with molecular genetic abnormalities and clinicopathological features , 2000, British Journal of Cancer.
[382] L. Norton,et al. Phase I studies of anti-epidermal growth factor receptor chimeric antibody C225 alone and in combination with cisplatin. , 2000, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[383] J. Minna,et al. Mutations in the retinoblastoma-related gene RB2/p130 in lung tumors and suppression of tumor growth in vivo by retrovirus-mediated gene transfer. , 2000, Cancer research.
[384] D. Hanahan,et al. The Hallmarks of Cancer , 2000, Cell.
[385] J. Luketich,et al. Sex-specific expression of gastrin-releasing peptide receptor: relationship to smoking history and risk of lung cancer. , 2000, Journal of the National Cancer Institute.
[386] J. Minna,et al. Molecular pathogenesis of lung cancer. , 1999, The Journal of thoracic and cardiovascular surgery.
[387] W. Prime,et al. Heterogeneous nuclear ribonucleoprotein A2/B1 up-regulation in bronchial lavage specimens: a clinical marker of early lung cancer detection. , 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.
[388] A. Hamburger,et al. ErbB‐2 kinase is required for constitutive stat 3 activation in malignant human lung epithelial cells , 1999, International journal of cancer.
[389] S. Larson,et al. Phase I and imaging trial of a monoclonal antibody directed against gastrin-releasing peptide in patients with lung cancer. , 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.
[390] E. Brambilla,et al. Alterations of expression of Rb, p16INK4A and cyclin D1 in non‐small cell lung carcinoma and their clinical significance , 1999, The Journal of pathology.
[391] D. E. Henson,et al. Molecular Pathology of Early Cancer , 1999 .
[392] J. Minna,et al. Induction of apoptosis and inhibition of tumorigenicity and tumor growth by adenovirus vector-mediated fragile histidine triad (FHIT) gene overexpression. , 1999, Cancer research.
[393] O. Miettinen,et al. Early Lung Cancer Action Project: overall design and findings from baseline screening , 1999, The Lancet.
[394] D. Spandidos,et al. Microsatellite DNA instability in COPD. , 1999, Chest.
[395] G. Thomas,et al. Fine deletion mapping of chromosome 8p in non‐small‐cell lung carcinoma , 1999, International journal of cancer.
[396] C. Harris,et al. Mutational analysis of p73 and p53 in human cancer cell lines , 1999, Oncogene.
[397] W. Hahn,et al. The telomerase catalytic subunit is a widely expressed tumor-associated antigen recognized by cytotoxic T lymphocytes. , 1999, Immunity.
[398] J. Minna,et al. Refined mapping of two regions of loss of heterozygosity on chromosome band 11q23 in lung cancer , 1999, Genes, chromosomes & cancer.
[399] J. Yokota,et al. Activation of RB tumor suppressor protein and growth suppression of small cell lung carcinoma cells by reintroduction of p16INK4A gene. , 1999, International journal of oncology.
[400] W. Smythe,et al. Cadherin and catenin expression in normal human bronchial epithelium and non-small cell lung cancer. , 1999, Lung cancer.
[401] W. Prime,et al. Genetic alterations in bronchial lavage as a potential marker for individuals with a high risk of developing lung cancer. , 1999, Cancer research.
[402] J. Minna,et al. Expression of DMBT1, a candidate tumor suppressor gene, is frequently lost in lung cancer. , 1999, Cancer research.
[403] J. Minna,et al. Allelic losses at chromosome 8p21-23 are early and frequent events in the pathogenesis of lung cancer. , 1999, Cancer research.
[404] M. Higashiyama,et al. A novel molecular staging protocol for non-small cell lung cancer , 1999, Oncogene.
[405] J. Minna,et al. Correlation of abnormal RB, p16ink4a, and p53 expression with 3p loss of heterozygosity, other genetic abnormalities, and clinical features in 103 primary non-small cell lung cancers. , 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.
[406] G. Dekan,et al. The TP53 genotype but not immunohistochemical result is predictive of response to cisplatin-based neoadjuvant therapy in stage III non-small cell lung cancer. , 1999, The Journal of thoracic and cardiovascular surgery.
[407] W. Lee,et al. RB-mediated suppression of spontaneous multiple neuroendocrine neoplasia and lung metastases in Rb+/- mice. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[408] J. Herman,et al. Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. , 1999, Cancer research.
[409] Y. Ishikawa,et al. Abnormal FHIT transcripts found in both lung cancer and normal lung tissue , 1999, Genes, chromosomes & cancer.
[410] Jose M. Silva,et al. TP53 gene mutations in plasma DNA of cancer patients , 1999, Genes, chromosomes & cancer.
[411] M. Rooney,et al. Prognostic significance of K-ras codon 12 mutations in patients with resected stage I and II non-small-cell lung cancer. , 1999, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[412] T. Hideshima,et al. p53 mutations predict non-small cell lung carcinoma response to radiotherapy. , 1999, Cancer letters.
[413] J. Minna,et al. Sequential molecular abnormalities are involved in the multistage development of squamous cell lung carcinoma , 1999, Oncogene.
[414] W P Bennett,et al. Molecular epidemiology of human cancer risk: gene–environment interactions and p53 mutation spectrum in human lung cancer , 1999, The Journal of pathology.
[415] K. Kinzler,et al. Genetic instabilities in human cancers , 1998, Nature.
[416] R. Perng,et al. Presence of serum anti-p53 antibodies is associated with pleural effusion and poor prognosis in lung cancer patients. , 1998, Clinical cancer research : an official journal of the American Association for Cancer Research.
[417] P. Dayer,et al. Role of glutathione S-transferase GSTM1, GSTM3, GSTP1 and GSTT1 genotypes in modulating susceptibility to smoking-related lung cancer. , 1998, Pharmacogenetics.
[418] L. Marchand,et al. Associations of CYP1A1, GSTM1, and CYP2E1 polymorphisms with lung cancer suggest cell type specificities to tobacco carcinogens. , 1998, Cancer research.
[419] Y. Yatabe,et al. Clinical implications of p53 autoantibodies in the sera of patients with non-small-cell lung cancer. , 1998, Journal of the National Cancer Institute.
[420] J. Minna,et al. Alterations of the PPP2R1B gene in human lung and colon cancer. , 1998, Science.
[421] E Gabrielson,et al. Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[422] R. Brezinschek,et al. Mutation analysis of the PTEN/MMAC1 gene in lung cancer , 1998, Oncogene.
[423] E. Brambilla,et al. The human p19ARF protein encoded by the beta transcript of the p16INK4a gene is frequently lost in small cell lung cancer. , 1998, Cancer research.
[424] J. Minna,et al. Progress in understanding the molecular pathogenesis of human lung cancer. , 1998, Biochimica et biophysica acta.
[425] W. Hong,et al. Effective treatment of early endobronchial cancer with regional administration of liposome-p53 complexes. , 1998, Journal of the National Cancer Institute.
[426] E. Brambilla,et al. p53 mutant immunophenotype and deregulation of p53 transcription pathway (Bcl2, Bax, and Waf1) in precursor bronchial lesions of lung cancer. , 1998, Clinical cancer research : an official journal of the American Association for Cancer Research.
[427] W. Richards,et al. Molecular pathologic substaging in 244 stage I non-small-cell lung cancer patients: clinical implications. , 1998, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[428] C. Harris,et al. Vascular endothelial growth factor and nitric oxide synthase expression in human lung cancer and the relation to p53. , 1998, British Journal of Cancer.
[429] L. Liotta,et al. Allelic deletion analysis of the FHIT gene predicts poor survival in non-small cell lung cancer. , 1998, Cancer research.
[430] B. Dutrillaux,et al. Mutations in OGG1, a gene involved in the repair of oxidative DNA damage, are found in human lung and kidney tumours , 1998, Oncogene.
[431] L. Liotta,et al. p21waf1/cip1 and transforming growth factor beta 1 protein expression correlate with survival in non-small cell lung cancer. , 1998, Clinical cancer research : an official journal of the American Association for Cancer Research.
[432] G. Tucker,et al. Meta-analysis of studies of the CYP2D6 polymorphism in relation to lung cancer and Parkinson's disease. , 1998, Pharmacogenetics.
[433] Tomohiko Maehama,et al. The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate* , 1998, The Journal of Biological Chemistry.
[434] S. Satoh,et al. Expression of facilitative glucose transporter isoforms in lung carcinomas: its relation to histologic type, differentiation grade, and tumor stage. , 1998, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.
[435] Feng Li,et al. Mass screening for lung cancer with mobile spiral computed tomography scanner , 1998, The Lancet.
[436] J. Minna,et al. Allelotyping demonstrates common and distinct patterns of chromosomal loss in human lung cancer types , 1998, Genes, chromosomes & cancer.
[437] P. Zimmerman,et al. KRAS codon 12 mutations in Australian non-small cell lung cancer. , 1998, Australian and New Zealand Journal of Medicine.
[438] S. Nomoto,et al. Search for mutations and examination of allelic expression imbalance of the p73 gene at 1p36.33 in human lung cancers. , 1998, Cancer research.
[439] J. V. van Noord,et al. Reduced E-cadherin expression is associated with increased lymph node metastasis and unfavorable prognosis in non-small cell lung cancer. , 1998, American journal of respiratory and critical care medicine.
[440] F. Kaye,et al. Protein expression and functional analysis of the FHIT gene in human tumor cells. , 1998, Journal of the National Cancer Institute.
[441] H. Naiki,et al. Expression of CD44 variant exon 6 in stage I non-small cell lung carcinoma as a prognostic factor. , 1998, Cancer research.
[442] R. Salgia,et al. Molecular abnormalities in lung cancer. , 1998, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[443] M. Higashiyama,et al. Reduced integrin alpha3 expression as a factor of poor prognosis of patients with adenocarcinoma of the lung. , 1998, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[444] J. Yokota,et al. Identification of CpG islands hypermethylated in human lung cancer by the arbitrarily primed-PCR method , 1998, Human Genetics.
[445] Y. Yatabe,et al. p27KIP1 in human lung cancers: differential changes in small cell and non-small cell carcinomas. , 1998, Cancer research.
[446] A. Giordano,et al. p21waf1/cip1mda-6 expression in non-small-cell lung cancer: relationship to survival. , 1998, American journal of respiratory cell and molecular biology.
[447] V. Gouyer,et al. Mechanisms of p16INK4A inactivation in non small-cell lung cancers , 1998, Oncogene.
[448] M. Stratton,et al. A serine/threonine kinase gene defective in Peutz–Jeghers syndrome , 1998, Nature.
[449] L. D. Barnes,et al. Replacement of Fhit in cancer cells suppresses tumorigenicity. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[450] C. Bingle,et al. Thyroid transcription factor-1. , 1997, The international journal of biochemistry & cell biology.
[451] T. Zhukov,et al. Prospective detection of preclinical lung cancer: results from two studies of heterogeneous nuclear ribonucleoprotein A2/B1 overexpression. , 1997, Clinical cancer research : an official journal of the American Association for Cancer Research.
[452] E. Dmitrovsky,et al. High telomerase activity in primary lung cancers: association with increased cell proliferation rates and advanced pathologic stage. , 1997, Journal of the National Cancer Institute.
[453] D. Warburton,et al. Cyclin D1 antisense RNA destabilizes pRb and retards lung cancer cell growth. , 1997, American journal of physiology. Lung cellular and molecular physiology.
[454] Y. Miller,et al. Widely dispersed p53 mutation in respiratory epithelium. A novel mechanism for field carcinogenesis. , 1997, The Journal of clinical investigation.
[455] J. Siegfried,et al. Prognostic value of specific KRAS mutations in lung adenocarcinomas. , 1997, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
[456] Mark A. Stephenson,et al. Overexpression of glut1 and glut3 in stage I nonsmall cell lung carcinoma is Associated with poor survival , 1997, Cancer.
[457] Esposito,et al. Prognostic role of the cyclin-dependent kinase inhibitor p27 in non-small cell lung cancer. , 1997, Cancer research.
[458] J. Siegfried,et al. Expression of mRNA for gastrin-releasing peptide receptor by human bronchial epithelial cells. Association with prolonged tobacco exposure and responsiveness to bombesin-like peptides. , 1997, American journal of respiratory and critical care medicine.
[459] M. Buyse,et al. Immunocytochemical markers in stage I lung cancer: relevance to prognosis. , 1997, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[460] K. Yasumoto,et al. Prognostic value of the immunohistochemical detection of p16INK4 expression in nonsmall cell lung carcinoma , 1997, Cancer.
[461] J. Samet,et al. Molecular damage in the bronchial epithelium of current and former smokers. , 1997, Journal of the National Cancer Institute.
[462] J. Mulshine,et al. Antitumor activity of a monoclonal antibody directed against gastrin-releasing peptide in patients with small cell lung cancer. , 1997, Chest.
[463] J. Jen,et al. Comparison of oncogene mutation detection and telomerase activity for the molecular staging of non-small cell lung cancer. , 1997, Clinical cancer research : an official journal of the American Association for Cancer Research.
[464] R. Rosell,et al. Reduced survival in patients with stage‐I non‐small‐cell lung cancer associated with DNA‐replication errors , 1997, International journal of cancer.
[465] J S Lee,et al. Clonal genetic alterations in the lungs of current and former smokers. , 1997, Journal of the National Cancer Institute.
[466] C. Angeletti,et al. Angiogenesis as a prognostic indicator of survival in non-small-cell lung carcinoma: a prospective study. , 1997, Journal of the National Cancer Institute.
[467] S. Petersen,et al. Patterns of chromosomal imbalances in adenocarcinoma and squamous cell carcinoma of the lung. , 1997, Cancer research.
[468] I. Wistuba,et al. Telomerase expression in respiratory epithelium during the multistage pathogenesis of lung carcinomas. , 1997, Cancer research.
[469] G. Giaccone,et al. FHIT and FRA3B 3p14.2 allele loss are common in lung cancer and preneoplastic bronchial lesions and are associated with cancer-related FHIT cDNA splicing aberrations. , 1997, Cancer research.
[470] G. Giaccone,et al. Prognostic value of the expression of p53, bcl-2, and bax oncoproteins, and neovascularization in patients with radically resected non-small-cell lung cancer. , 1997, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[471] A. Marchetti,et al. Association between cigarette smoking and FHIT gene alterations in lung cancer. , 1997, Cancer research.
[472] S. Ishiguro,et al. MDM2 gene amplification and expression in non-small-cell lung cancer: immunohistochemical expression of its protein is a favourable prognostic marker in patients without p53 protein accumulation. , 1997, British Journal of Cancer.
[473] D. Bell,et al. Advances in the analysis of chromosome alterations in human lung carcinomas. , 1997, Cancer genetics and cytogenetics.
[474] F. Hirahara,et al. Expression of gelatinase A, tissue inhibitor of metalloproteinases-2, matrilysin, and trypsin(ogen) in lung neoplasms: an immunohistochemical study. , 1997, Human pathology.
[475] C. Angeletti,et al. Neoangiogenesis and p53 protein in lung cancer: their prognostic role and their relation with vascular endothelial growth factor (VEGF) expression. , 1997, British Journal of Cancer.
[476] W. K. Alfred Yung,et al. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers , 1997, Nature Genetics.
[477] W. Benedict,et al. Altered retinoblastoma protein expression in nonsmall cell lung cancer , 1997, Cancer.
[478] M. Volm,et al. Prognostic value of basic fibroblast growth factor and its receptor (FGFR-1) in patients with non-small cell lung carcinomas. , 1997, European journal of cancer.
[479] K. Kerr,et al. THE PATTERN OF K‐rasMUTATION IN PULMONARY ADENOCARCINOMA DEFINES A NEW PATHWAY OF TUMOUR DEVELOPMENT IN THE HUMAN LUNG , 1997, The Journal of pathology.
[480] M. Wigler,et al. PTEN, a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer , 1997, Science.
[481] D. Romberger,et al. Bombesin-like peptides and airway repair: a recapitulation of lung development? , 1997, American journal of respiratory cell and molecular biology.
[482] A. El‐Naggar,et al. Differential retinoblastoma protein expression in neuroendocrine tumors of the lung. Potential diagnostic implications. , 1997, The American journal of pathology.
[483] M. Volm,et al. Prognostic value of vascular endothelial growth factor and its receptor Flt‐1 in squamous cell lung cancer , 1997, International journal of cancer.
[484] A. Schally,et al. Reduction in receptors for bombesin and epidermal growth factor in xenografts of human small-cell lung cancer after treatment with bombesin antagonist RC-3095. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[485] A. Marchetti,et al. Alterations of P16 (MTS1) in node‐positive non‐small cell lung carcinomas , 1997, The Journal of pathology.
[486] L. Weissfeld,et al. Association of immunoreactive hepatocyte growth factor with poor survival in resectable non-small cell lung cancer. , 1997, Cancer research.
[487] G. Bepler,et al. Delineation of the centromeric and telomeric chromosome segment 11p15.5 lung cancer suppressor regions LOH11A and LOH11B , 1997, Genes, chromosomes & cancer.
[488] M. Higashiyama,et al. bcl‐2 oncoprotein in surgically resected nonsmall cell lung cancer: Possibly favorable prognostic factor in association with low incidence of distant metastasis , 1997, Journal of surgical oncology.
[489] H. Dosaka-akita,et al. Altered p16INK4 and retinoblastoma protein status in non-small cell lung cancer: potential synergistic effect with altered p53 protein on proliferative activity. , 1996, Cancer research.
[490] P. Zimmerman,et al. MYCL genotypes and loss of heterozygosity in non-small-cell lung cancer. , 1996, British Journal of Cancer.
[491] E. Brambilla,et al. Apoptosis-related factors p53, Bcl2, and Bax in neuroendocrine lung tumors. , 1996, The American journal of pathology.
[492] R. Ball,et al. IMMUNOREACTIVITY FOR HEPATOCYTE GROWTH FACTOR/SCATTER FACTOR AND ITS RECEPTOR, met, IN HUMAN LUNG CARCINOMAS AND MALIGNANT MESOTHELIOMAS , 1996, The Journal of pathology.
[493] P. Comoglio,et al. Overexpression and activation of hepatocyte growth factor/scatter factor in human non-small-cell lung carcinomas. , 1996, British Journal of Cancer.
[494] B. Karlan,et al. DNA sequence analysis of exons 2 through 11 and immunohistochemical staining are required to detect all known p53 alterations in human malignancies. , 1996, Oncogene.
[495] M. Mabry,et al. Mechanism of all-trans-retinoic acid-mediated L-myc gene regulation in small cell lung cancer. , 1996, Oncogene.
[496] H. Kato,et al. A comparison of epidermal growth factor receptor levels and other prognostic parameters in non-small cell lung cancer. , 1996, European journal of cancer.
[497] M. Tang,et al. Preferential Formation of Benzo[a]pyrene Adducts at Lung Cancer Mutational Hotspots in P53 , 1996, Science.
[498] T. Yamamoto,et al. Immunohistochemical detection of basic fibroblast growth factor as a prognostic indicator in pulmonary adenocarcinoma. , 1996, Japanese journal of clinical oncology.
[499] A. Kurt,et al. Microsatellite alterations in plasma DNA of small cell lung cancer patients , 1996, Nature Medicine.
[500] W. Hong,et al. Retrovirus–mediated wild–type P53 gene transfer to tumors of patients with lung cancer. , 1996, Nature Medicine.
[501] D. Hanahan,et al. Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis , 1996, Cell.
[502] H. Kreipe,et al. Expression of bcl-2--protein in small cell lung cancer. , 1996, Lung cancer.
[503] A. Chella,et al. Prognostic significance of tumoral angiogenesis in completely resected late stage lung carcinoma (Stage IIIA‐N2): Impact of adjuvant therapies in a subset of patients at high risk of recurrence , 1996, Cancer.
[504] D. Niewoehner,et al. Rb and p16INK4a expression in resected non-small cell lung tumors. , 1996, Cancer research.
[505] J. Testa,et al. Detection of aneuploidy in interphase nuclei from non-small cell lung carcinomas by fluorescence in situ hybridization using chromosome-specific repetitive DNA probes. , 1996, Cancer genetics and cytogenetics.
[506] J. Yokota,et al. Induction of apoptosis but not G1 arrest by expression of the wild-type p53 gene in small cell lung carcinoma. , 1996, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.
[507] C. Rose,et al. Lack of prognostic significance of epidermal growth factor receptor and the oncoprotein p185HER-2 in patients with systemically untreated non-small-cell lung cancer: an immunohistochemical study on cryosections. , 1996, British Journal of Cancer.
[508] S. Hirohashi,et al. Deletion mapping of chromosome 2 in human lung carcinoma , 1996, Genes, chromosomes & cancer.
[509] U. Pastorino,et al. Microsatellite alterations in bronchial and sputum specimens of lung cancer patients. , 1996, Cancer research.
[510] J. Battey,et al. Insulin-like Growth Factor Expression in Human Cancer Cell Lines (*) , 1996, The Journal of Biological Chemistry.
[511] R. Hruban,et al. K-ras oncogene activation in atypical alveolar hyperplasias of the human lung. , 1996, Cancer research.
[512] C. Croce,et al. The FHIT Gene at 3p14.2 Is Abnormal in Lung Cancer , 1996, Cell.
[513] M. Volm,et al. Association of vascular endothelial growth factor expression with intratumoral microvessel density and tumour cell proliferation in human epidermoid lung carcinoma. , 1996, British Journal of Cancer.
[514] J. Minna,et al. Construction of a 600-kilobase cosmid clone contig and generation of a transcriptional map surrounding the lung cancer tumor suppressor gene (TSG) locus on human chromosome 3p21.3: progress toward the isolation of a lung cancer TSG. , 1996, Cancer research.
[515] D. Ward,et al. Karyotyping human chromosomes by combinatorial multi-fluor FISH , 1996, Nature Genetics.
[516] S. Elledge,et al. Selective maternal-allele loss in human lung cancers of the maternally expressed p57KIP2 gene at 11p15.5. , 1996, Oncogene.
[517] A. Marchetti,et al. p21 RNA and protein expression in non-small cell lung carcinomas: evidence of p53-independent expression and association with tumoral differentiation. , 1996, Oncogene.
[518] A. Okamoto,et al. Intragenic mutations of the p16INK4, p15INK4B and p18 genes in primary non‐small‐cell lung cancers , 1996 .
[519] S. Jiang,et al. Bcl-2 protein expression in lung cancer and close correlation with neuroendocrine differentiation. , 1996, The American journal of pathology.
[520] R. Ueda,et al. Prognostic significance of abnormal p53 accumulation in primary, resected non-small-cell lung cancers. , 1996, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[521] W. Ryder,et al. Prognostic significance of CCND1 (cyclin D1) overexpression in primary resected non-small-cell lung cancer. , 1996, British Journal of Cancer.
[522] G. Krystal,et al. Autocrine growth of small cell lung cancer mediated by coexpression of c-kit and stem cell factor. , 1996, Cancer research.
[523] A. Gazdar,et al. Extensive areas of aneuploidy are present in the respiratory epithelium of lung cancer patients. , 1996, British Journal of Cancer.
[524] D. Mukhopadhyay,et al. Wild-type p53 and v-Src exert opposing influences on human vascular endothelial growth factor gene expression. , 1995, Cancer research.
[525] S. Hirohashi,et al. Microsatellite instability in primary and metastatic lung carcinomas , 1995, Genes, chromosomes & cancer.
[526] S. Lam,et al. Evidence of cumulative gene losses with progression of premalignant epithelial lesions to carcinoma of the bronchus. , 1995, Cancer research.
[527] M. Kelley,et al. Mechanism of inactivation of CDKN2 and MTS2 in non-small cell lung cancer and association with advanced stage. , 1995, Oncogene.
[528] P. Zimmerman,et al. Loss of heterozygosity frequently affects chromosome 17q in non-small cell lung cancer. , 1995, Cancer research.
[529] F. Kaye,et al. CDKN2 gene silencing in lung cancer by DNA hypermethylation and kinetics of p16INK4 protein induction by 5-aza 2'deoxycytidine. , 1995, Oncogene.
[530] S. Zienolddiny,et al. A hereditary genetic marker closely associated with microsatellite instability in lung cancer. , 1995, Cancer research.
[531] M. Shipp,et al. Stromelysin-3 is overexpressed by stromal elements in primary non-small cell lung cancers and regulated by retinoic acid in pulmonary fibroblasts. , 1995, Cancer research.
[532] J. Minna,et al. Allele-specific loss in chromosome 9p loci in preneoplastic lesions accompanying non-small-cell lung cancers. , 1995, Journal of the National Cancer Institute.
[533] T. Soussi,et al. Serum p53 antibodies as early markers of lung cancer , 1995, Nature Medicine.
[534] J. Herman,et al. 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers , 1995, Nature Medicine.
[535] J. Gray,et al. Identification of novel regions of altered DNA copy number in small cell lung tumors , 1995, Genes, chromosomes & cancer.
[536] R. Whyte,et al. Expression and activation of erbB-2 and epidermal growth factor receptor in lung adenocarcinomas. , 1995, British Journal of Cancer.
[537] A. Gazdar,et al. Telomerase activity in small-cell and non-small-cell lung cancers. , 1995, Journal of the National Cancer Institute.
[538] S. Steinberg,et al. Differential inactivation of CDKN2 and Rb protein in non-small-cell and small-cell lung cancer cell lines. , 1995, Journal of the National Cancer Institute.
[539] C. Angeletti,et al. Bcl-2 protein: a prognostic factor inversely correlated to p53 in non-small-cell lung cancer. , 1995, British Journal of Cancer.
[540] J. Whitsett,et al. Gene Structure and Expression of Human Thyroid Transcription Factor-1 in Respiratory Epithelial Cells (*) , 1995, The Journal of Biological Chemistry.
[541] Jorma Isola,et al. In vivo amplification of the androgen receptor gene and progression of human prostate cancer , 1995, Nature Genetics.
[542] J. Minna,et al. Allele-specific chromosome 3p deletions occur at an early stage in the pathogenesis of lung carcinoma. , 1995, JAMA.
[543] C. D. Edwards,et al. Reciprocal Rb inactivation and p16INK4 expression in primary lung cancers and cell lines. , 1995, Cancer research.
[544] P. Zimmerman,et al. Tumor progression and loss of heterozygosity at 5q and 18q in non-small cell lung cancer. , 1995, Cancer research.
[545] V. Rusch,et al. p53 immunostaining positivity is associated with reduced survival and is imperfectly correlated with gene mutations in resected non-small cell lung cancer. A preliminary report of LCSG 871. , 1994, Chest.
[546] A. Gazdar,et al. K-ras mutations are a relatively late event in the pathogenesis of lung carcinomas. , 1994, Cancer research.
[547] A. Okamoto,et al. Mutations and altered expression of p16INK4 in human cancer. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[548] J. Yokota,et al. Frequent allelic losses on chromosomes 2q, 18q, and 22q in advanced non-small cell lung carcinoma. , 1994, Cancer research.
[549] Y. Nakamura,et al. Difference of allelotype between squamous cell carcinoma and adenocarcinoma of the lung. , 1994, Cancer research.
[550] C. Harris,et al. Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. , 1994, Cancer research.
[551] T. Sellers,et al. Segregation analysis of smoking-associated malignancies: evidence for Mendelian inheritance. , 1994, American journal of medical genetics.
[552] K. Kok,et al. A homozygous deletion in a small cell lung cancer cell line involving a 3p21 region with a marked instability in yeast artificial chromosomes. , 1994, Cancer research.
[553] P. Zimmerman,et al. Correlation of loss of heterozygosity at 11 p with tumour progression and survival in non‐small cell lung cancer , 1994, Genes, chromosomes & cancer.
[554] G. Nicolson,et al. c-erbB-2/neu overexpression enhances metastatic potential of human lung cancer cells by induction of metastasis-associated properties. , 1994, Cancer research.
[555] W. Benedict,et al. Altered retinoblastoma protein expression and prognosis in early-stage non-small-cell lung carcinoma. , 1994, Journal of the National Cancer Institute.
[556] D. Carson,et al. Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers , 1994, Nature.
[557] M. Skolnick,et al. A cell cycle regulator potentially involved in genesis of many tumor types. , 1994, Science.
[558] W. Kolch,et al. Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression. , 1994, Oncogene.
[559] M. Caligiuri,et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice , 1994, Nature.
[560] F. Askin,et al. Frequent loss of chromosome 9 in human primary non-small cell lung cancer. , 1994, Cancer research.
[561] S. Rodenhuis,et al. C-erbB-2 expression and codon 12 K-ras mutations both predict shortened survival for patients with pulmonary adenocarcinomas. , 1994, The Journal of clinical investigation.
[562] D. Shibata,et al. c-k-ras and p53 mutations occur very early in adenocarcinoma of the lung. , 1994, The American journal of pathology.
[563] Yoshiro,et al. Genesis of squamous cell lung carcinoma. Sequential changes of proliferation, DNA ploidy, and p53 expression. , 1994, The American journal of pathology.
[564] H. Katz. bcl-2 protein in non-small-cell lung carcinoma. , 1994, The New England journal of medicine.
[565] K. Matsumoto,et al. Hepatocyte growth factor may act as a pulmotrophic factor on lung regeneration after acute lung injury. , 1993, The Journal of biological chemistry.
[566] J. Minna,et al. Human lung cancer cell lines exhibit resistance to retinoic acid treatment. , 1993, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.
[567] P. Carlson,et al. c-myc expression correlates with suppression of c-kit protooncogene expression in small cell lung cancer cell lines. , 1993, Cancer research.
[568] J. Mate,et al. Prognostic impact of mutated K-ras gene in surgically resected non-small cell lung cancer patients. , 1993, Oncogene.
[569] J. Yokota,et al. Reconstitution of the RB gene suppresses the growth of small-cell lung carcinoma cells carrying multiple genetic alterations. , 1993, Oncogene.
[570] J. Minna,et al. Expression of c-myc in progenitor cells of the bronchopulmonary epithelium and in a large number of non-small cell lung cancers. , 1993, American journal of respiratory cell and molecular biology.
[571] R. Figlin,et al. Inactivation of the retinoblastoma susceptibility gene in non-small-cell lung cancer. The Lung Cancer Study Group. , 1993, Oncogene.
[572] A. Gazdar,et al. Correlation of intrinsic chemoresistance of non-small-cell lung cancer cell lines with HER-2/neu gene expression but not with ras gene mutations. , 1993, Journal of the National Cancer Institute.
[573] Y. Nakamura,et al. Deletion mapping of the short arm of chromosome 8 in non‐small cell lung carcinoma , 1993, Genes, chromosomes & cancer.
[574] E. Dmitrovsky,et al. Differential expression of the epidermal growth factor receptor and its ligands in primary non-small cell lung cancers and adjacent benign lung. , 1993, Cancer research.
[575] C. Harris,et al. Biological consequences of overexpression of a transfected c-erbB-2 gene in immortalized human bronchial epithelial cells. , 1993, Cancer research.
[576] M. Spang‐Thomsen,et al. Expression of myc family oncoproteins in small‐cell lung‐cancer cell lines and xenografts , 1993, International journal of cancer.
[577] T. Tsukamoto,et al. Recombinant human stem cell factor mediates chemotaxis of small-cell lung cancer cell lines aberrantly expressing the c-kit protooncogene. , 1993, Cancer research.
[578] Johnson Be,et al. The biology of lung cancer. , 1993, Seminars in oncology.
[579] Y. Miller,et al. Small cell lung cancer: etiology, biology, clinical features, staging, and treatment. , 1993, Current problems in cancer.
[580] R. Ueda,et al. Frequent homozygous deletions in lung cancer cell lines detected by a DNA marker located at 3p21.3-p22. , 1993, Oncogene.
[581] T. Nakamura,et al. Expression of the proto-oncogenes c-met and c-kit and their ligands, hepatocyte growth factor/scatter factor and stem cell factor, in SCLC cell lines and xenografts. , 1993, British Journal of Cancer.
[582] E. Oldfield,et al. Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors. , 1992, Cancer research.
[583] H. Poulsen,et al. Expression of the epidermal growth factor receptor in human small cell lung cancer cell lines. , 1992, Cancer research.
[584] S. Rodenhuis,et al. Clinical significance of ras oncogene activation in human lung cancer. , 1992, Cancer research.
[585] H. Antoniades,et al. Malignant epithelial cells in primary human lung carcinomas coexpress in vivo platelet-derived growth factor (PDGF) and PDGF receptor mRNAs and their protein products. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[586] R. Ueda,et al. Three distinct regions involved in 3p deletion in human lung cancer. , 1992, Oncogene.
[587] S. Baylin,et al. Distinct hypermethylation patterns occur at altered chromosome loci in human lung and colon cancer. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[588] T Takahashi,et al. Coexpression of the stem cell factor and the c-kit genes in small-cell lung cancer. , 1991, Oncogene.
[589] S. Steinberg,et al. ras gene mutations in non-small cell lung cancers are associated with shortened survival irrespective of treatment intent. , 1991, Cancer research.
[590] S. Rodenhuis,et al. Relationship between K-ras oncogene activation and smoking in adenocarcinoma of the human lung. , 1991, Journal of the National Cancer Institute.
[591] B. Vogelstein,et al. p53 mutations in human cancers. , 1991, Science.
[592] K. Sugimachi,et al. Immunohistochemical evidence of autocrine growth factors in adenocarcinoma of the human lung. , 1990, Cancer research.
[593] J. Minna,et al. Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer. Lung Cancer Study Group. , 1990, Oncogene.
[594] S. Rodenhuis,et al. K-ras oncogene activation as a prognostic marker in adenocarcinoma of the lung. , 1990, The New England journal of medicine.
[595] S. Naylor,et al. Altered structure and expression of the human retinoblastoma susceptibility gene in small cell lung cancer. , 1990, Cancer research.
[596] A. Levine,et al. Association of human papillomavirus types 16 and 18 E6 proteins with p53. , 1990, Science.
[597] P. Nowell,et al. Expression of the neu gene-encoded protein (P185neu) in human non-small cell carcinomas of the lung. , 1990, Cancer research.
[598] M. Noguchi,et al. Amplification of protooncogenes in surgical specimens of human lung carcinomas. , 1989, Cancer research.
[599] J. Minna,et al. p53: a frequent target for genetic abnormalities in lung cancer. , 1989, Science.
[600] J. Roth,et al. Differential expression of the c-erbB-2 gene in human small cell and non-small cell lung cancer. , 1989, Cancer research.
[601] G. Draper,et al. Non-ocular cancer in relatives of retinoblastoma patients. , 1989, British Journal of Cancer.
[602] R. Ueda,et al. Expression and amplification of myc gene family in small cell lung cancer and its relation to biological characteristics. , 1989, Cancer research.
[603] Knudson Ag. The ninth Gordon Hamilton-Fairley memorial lecture: Hereditary cancers: clues to mechanisms of carcinogenesis , 1989 .
[604] K. Münger,et al. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. , 1989, Science.
[605] J. Battey,et al. Multiple mechanisms for transcriptional regulation of the myc gene family in small-cell lung cancer , 1988, Molecular and cellular biology.
[606] J. Minna,et al. Abnormalities in structure and expression of the human retinoblastoma gene in SCLC. , 1988, Science.
[607] J. Minna,et al. Molecular genetics of lung cancer. , 1988, Annual review of medicine.
[608] J. Osinga,et al. Deletion of a DNA sequence at the chromosomal region 3p21 in all major types of lung cancer , 1987, Nature.
[609] S. Rodenhuis,et al. Mutational activation of the K-ras oncogene. A possible pathogenetic factor in adenocarcinoma of the lung. , 1987, The New England journal of medicine.
[610] P. Zimmerman,et al. PLOIDY AS A PROGNOSTIC DETERMINANT IN SURGICALLY TREATED LUNG CANCER , 1987, The Lancet.
[611] N. Bleehen,et al. Oncogene amplification and chromosomal abnormalities in small cell lung cancer , 1987, Journal of cellular biochemistry.
[612] Stephen H. Friend,et al. A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma , 1986, Nature.
[613] J. Battey,et al. Human small-cell lung cancers show amplification and expression of the N-myc gene. , 1986, Proceedings of the National Academy of Sciences of the United States of America.
[614] R. Elston,et al. Increased familial risk for lung cancer. , 1986, Journal of the National Cancer Institute.
[615] J. Battey,et al. L-myc, a new myc-related gene amplified and expressed in human small cell lung cancer , 1985, Nature.
[616] K. Semba,et al. A v-erbB-related protooncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma. , 1985, Proceedings of the National Academy of Sciences of the United States of America.
[617] P. Seeburg,et al. Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells , 1984, Nature.
[618] R. Evans,et al. Expression cloning of human EGF receptor complementary DNA: gene amplification and three related messenger RNA products in A431 cells. , 1984, Science.
[619] Y H Xu,et al. Amplification and enhanced expression of the epidermal growth factor receptor gene in A431 human carcinoma cells. , 1984, Science.
[620] P. Nowell. The clonal evolution of tumor cell populations. , 1976, Science.
[621] S. Newsom,et al. LOCAL CHEMOTHERAPY FOR PSEUDOMONAS LUNG ABSCESS , 1974 .
[622] A. Lilienfeld,et al. Familial aggregation of lung cancer among hospital patients. , 1963, Public health reports.
[623] S Paget,et al. THE DISTRIBUTION OF SECONDARY GROWTHS IN CANCER OF THE BREAST. , 1889 .
[624] L. Tanoue. Incidence of human papilloma virus in lung cancer , 2011 .
[625] A. Jemal,et al. Global Cancer Statistics , 2011 .
[626] Richard Simon,et al. Gene expression-based prognostic signatures in lung cancer: ready for clinical use? , 2010, Journal of the National Cancer Institute.
[627] C. Croce,et al. MicroRNA dysregulation in cancer: opportunities for the development of microRNA-based drugs. , 2010, IDrugs : the investigational drugs journal.
[628] Paolo Boffetta,et al. Quantitative analysis of DNA methylation profiles in lung cancer identifies aberrant DNA methylation of specific genes and its association with gender and cancer risk factors. , 2009, Cancer research.
[629] J. Yokota,et al. Contribution of nicotine acetylcholine receptor polymorphisms to lung cancer risk in a smoking-independent manner in the Japanese. , 2009, Carcinogenesis.
[630] D. Hayes,et al. HIF2alpha cooperates with RAS to promote lung tumorigenesis in mice. , 2009, The Journal of clinical investigation.
[631] P. Jänne,et al. MET increased gene copy number and primary resistance to gefitinib therapy in non-small-cell lung cancer patients. , 2009, Annals of oncology : official journal of the European Society for Medical Oncology.
[632] 良一 小野里. LKB1 gene mutations in Japanese lung cancer patients , 2009 .
[633] G. Qiao,et al. KRAS Mutations and Primary Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib , 2008 .
[634] Y. Kotake,et al. pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene. , 2007, Genes & development.
[635] Yeul-Hong Kim,et al. Comparative genomic hybridization array analysis and real time PCR reveals genomic alterations in squamous cell carcinomas of the lung. , 2007, Lung cancer.
[636] Nicholas G Martin,et al. Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs. , 2007, Human molecular genetics.
[637] J. Luketich,et al. Aberrant promoter methylation of p16 and MGMT genes in lung tumors from smoking and never-smoking lung cancer patients. , 2006, Neoplasia.
[638] G. Watanabe,et al. Prognostic significance of p16(INK4a) hypermethylation in non-small cell lung cancer is evident by quantitative DNA methylation analysis. , 2006, Anticancer research.
[639] J. Rothberg,et al. Detection of oncogenic mutations in the EGFR gene in lung adenocarcinoma with differential sensitivity to EGFR tyrosine kinase inhibitors. , 2005, Cold Spring Harbor symposia on quantitative biology.
[640] L. Fabbri,et al. Role of chemotherapy and the receptor tyrosine kinases KIT, PDGFRalpha, PDGFRbeta, and Met in large-cell neuroendocrine carcinoma of the lung. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[641] Y. Ishikawa,et al. High K-ras mutation rates in goblet-cell-type adenocarcinomas of the lungs , 2005, Journal of Cancer Research and Clinical Oncology.
[642] Amie Y Lee,et al. A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells. , 2004, Neoplasia.
[643] N. Agnantis,et al. Expression of vascular endothelial growth factor (VEGF) and association with microvessel density in small-cell and non-small-cell lung carcinomas. , 2004, Histology and histopathology.
[644] J. Downward. Targeting RAS signalling pathways in cancer therapy , 2003, Nature Reviews Cancer.
[645] H. Kato,et al. Correlation between encoded protein overexpression and copy number of the HER2 gene with survival in non‐small cell lung cancer , 2003, International journal of cancer.
[646] F. Oesch,et al. Characterization of c-kit expression in small cell lung cancer: prognostic and therapeutic implications. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.
[647] M. Esteller. Cancer epigenetics: DNA methylation and chromatin alterations in human cancer. , 2003, Advances in experimental medicine and biology.
[648] Matty P. Weijenberg,et al. A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer , 2002, Nature Genetics.
[649] Yusuke Nakamura,et al. Identification of semaphorin3B as a direct target of p53. , 2002, Neoplasia.
[650] A. Bird. DNA methylation patterns and epigenetic memory. , 2002, Genes & development.
[651] F. Wright,et al. Global methylation profiling of lung cancer identifies novel methylated genes. , 2001, Neoplasia.
[652] E. Mark,et al. p16(INK4a) and histology-specific methylation of CpG islands by exposure to tobacco smoke in non-small cell lung cancer. , 2001, Cancer research.
[653] 平島 奈緒子. Protein overexpression and gene amplification of c-erb B-2 in pulmonary carcinomas : A comparative immunohistochemical and fluorescence in situ hybridization study , 2001 .
[654] A. Gazdar,et al. Early detection of lung cancer: clinical perspectives of recent advances in biology and radiology. , 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.
[655] J. Minna,et al. Aberrant promoter methylation of multiple genes in non-small cell lung cancers. , 2001, Cancer research.
[656] Taylor Murray,et al. Cancer statistics, 2000 , 2000, CA: a cancer journal for clinicians.
[657] J. Herman,et al. Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients. , 1999, Cancer research.
[658] R. Figlin,et al. Amplification and overexpression of the cyclin D1 and epidermal growth factor receptor genes in non-small-cell lung cancer , 1999, Journal of Cancer Research and Clinical Oncology.
[659] Joe W. Gray,et al. PIK3CA is implicated as an oncogene in ovarian cancer , 1999, Nature Genetics.
[660] G. Swanson,et al. Increased cancer risk among relatives of nonsmoking lung cancer cases , 1999, Genetic epidemiology.
[661] C I Amos,et al. Is there a genetic basis for lung cancer susceptibility? , 1999, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.
[662] M. Bibbo,et al. The role of pRb2/p130 protein in diagnosing lung carcinoma on fine needle aspiration biopsies. , 1999, Pathology, research and practice.
[663] M. Tschan,et al. Expression of p16INK4a/p16alpha and p19ARF/p16beta is frequently altered in non-small cell lung cancer and correlates with p53 overexpression. , 1998, Oncogene.
[664] I. Wistuba,et al. Molecular Abnormalities in the Sequential Development of Lung Carcinoma , 1998 .
[665] I. Petersen,et al. Small-cell lung cancer is characterized by a high incidence of deletions on chromosomes 3p, 4q, 5q, 10q, 13q and 17p. , 1997, British Journal of Cancer.
[666] M. Fukuoka,et al. Differential expressions of cyclin A and the retinoblastoma gene product in histological subtypes of lung cancer cell lines , 1997, Journal of Cancer Research and Clinical Oncology.
[667] S. Spivack,et al. The molecular epidemiology of lung cancer. , 1997, Critical reviews in toxicology.
[668] L. V. van't Veer,et al. Mutational activation of the K-ras oncogene and the effect of chemotherapy in advanced adenocarcinoma of the lung: a prospective study. , 1997, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[669] M. Caputi,et al. Prognostic role of cyclin D1 in non small cell lung cancer: an immunohistochemical analysis. , 1997, European journal of histochemistry : EJH.
[670] P. Hasleton,et al. Abnormal expression of CCND1 and RB1 in resection margin epithelia of lung cancer patients. , 1997, British Journal of Cancer.
[671] Y. Ishikawa,et al. A follow-up study of progression from dysplasia to squamous cell carcinoma with immunohistochemical examination of p53 protein overexpression in the bronchi of ex-chromate workers. , 1997, British Journal of Cancer.
[672] M. Oda,et al. Vascular endothelial growth factor and lymph node metastasis in primary lung cancer. , 1997, British Journal of Cancer.
[673] Tsung-Teh Wu,et al. Extracellular matrix expression in metastasizing and nonmetastasizing adenocarcinomas of the lung. , 1997, Human pathology.
[674] J. Shay,et al. Telomerase activity in human cancer. , 1996, Current opinion in oncology.
[675] S. Steinberg,et al. MYC family DNA amplification in 126 tumor cell lines from patients with small cell lung cancer , 1996, Journal of cellular biochemistry. Supplement.
[676] E. Sausville,et al. Bombesin receptor structure and expression in human lung carcinoma cell lines , 1996, Journal of cellular biochemistry. Supplement.
[677] Philip Smith,et al. Microsatellite instability and other molecular abnormalities in non-small cell lung cancer. , 1995, Cancer research.
[678] F. Kaye,et al. Absence of p16INK4 protein is restricted to the subset of lung cancer lines that retains wildtype RB. , 1994, Oncogene.
[679] D. Forman,et al. Metabolic polymorphisms in carcinogen metabolising enzymes and cancer susceptibility. , 1994, British medical bulletin.
[680] B. Johnson,et al. The biology of lung cancer. , 1993, Seminars in oncology.
[681] M. Groudine,et al. Control of c-myc regulation in normal and neoplastic cells. , 1991, Advances in cancer research.
[682] G. Del Sal,et al. Evidence of enhancement of the ras oncogene protein product (p21) in a spectrum of human tumors , 1989, International journal of cancer.
[683] J. Yokota,et al. Multiple genetic alterations in small-cell lung carcinoma. , 1989, Princess Takamatsu symposia.
[684] M. Matthews. Pathology of small cell lung cancer , 1985 .
[685] John D. Minna,et al. Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancer , 1985, Nature.
[686] J. Bingham. Letter: Lower oesophageal sphincter. , 1974, Lancet.