Age and gender may be the key points in hyperglycemic patients with Helicobacter pylori infection combined colorectal adenoma

To the Editor We highly commend the article by Kim et al1 who suggested Helicobacter pylori infection is an independent risk factor of colorectal neoplasm. He found the odds ratio (OR) for adenoma was 1.32 (95% confidence interval [CI]: 1.071.61) in participants with and without H. pylori infection, respectively. In our study, the similar result was also noted.2 However, we found the hyperglycemia status in participants who had H. pylori infection, but there were no significant differences in HbA1c level between those with and without H. pylori infection in Kim TJ study. We compared the demographic data of these two studies and found that age and gender may be the key points (Table 1). In Kim’s study, they recruited healthy male only and those aged 30 years or older, whereas in our study, we included both male and female and patients aged above 40 years. These differences may affect the glucose level in the study. Patients’ glucose level mentioned in our study (both glucose